Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods

Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods

The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon<sup>&#174;</sup> 12 PF and Kollidon<sup>&#174;</sup> VA 64) and various methods of preparing solid dispersions (solvent evaporation, s...

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Bibliographic Details
Main Authors: Tereza Školáková, Michaela Slámová, Andrea Školáková, Alena Kadeřábková, Jan Patera, Petr Zámostný
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pharmaceutics
Subjects:
solid dispersion
tadalafil
Wood’s apparatus
intrinsic dissolution rate
Weibull dissolution model
dissolution rate
Online Access:https://www.mdpi.com/1999-4923/11/8/383

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https://www.mdpi.com/1999-4923/11/8/383

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