Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in rats
Garden cress (Lepidium sativum) seeds are considered extensively in the folk medicine as anantidiabetic agent in many countries. The current investigations focuses attention on theglucose and lipid lowering effect of the aqueous extract of L. sativum seeds on experimentally induced diabetes in rats....
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| Format: | Article |
| Language: | English |
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University of Baghdad, College of Veterinary Medicine
2012-04-01
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| Series: | The Iraqi Journal of Veterinary Medicine |
| Subjects: | |
| Online Access: | https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/410 |
| _version_ | 1798029894262718464 |
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| author | Shahbaa M. Al-khazraji |
| author_facet | Shahbaa M. Al-khazraji |
| author_sort | Shahbaa M. Al-khazraji |
| collection | DOAJ |
| description | Garden cress (Lepidium sativum) seeds are considered extensively in the folk medicine as anantidiabetic agent in many countries. The current investigations focuses attention on theglucose and lipid lowering effect of the aqueous extract of L. sativum seeds on experimentally induced diabetes in rats. The biochemical parameters studied were plasma glucose, insulin, totalcholesterol,triglycerides,phospholipids,hemoglobin, and glycosylated hemoglobin.
In addition body weight and renal glucose reabsorption were notified. Aqueous extract of L. sativum were orally administered daily for 30 days in a dose of 20 mg / kg body weight to alloxan – diabetic rats , and a significant reduction in the parameters measured was investigated compared to diabetic rats. Meanwhile, Glibinclamide was used as standard reference drug. In cznclusion , L. sativum seeds possess a hypoglycaemic with concurrent hypolipidemic effect in diabetic states , and may further suggests thatL. Sativum may be useful in the therapy andmanagements of diabetic hyperlipidemia through reducing lipids levels . |
| first_indexed | 2024-04-11T19:32:35Z |
| format | Article |
| id | doaj.art-0b0027104ec14e249a1a98b1066ee91e |
| institution | Directory Open Access Journal |
| issn | 1609-5693 2410-7409 |
| language | English |
| last_indexed | 2024-04-11T19:32:35Z |
| publishDate | 2012-04-01 |
| publisher | University of Baghdad, College of Veterinary Medicine |
| record_format | Article |
| series | The Iraqi Journal of Veterinary Medicine |
| spelling | doaj.art-0b0027104ec14e249a1a98b1066ee91e2022-12-22T04:06:57ZengUniversity of Baghdad, College of Veterinary MedicineThe Iraqi Journal of Veterinary Medicine1609-56932410-74092012-04-01360E10.30539/iraqijvm.v36i0E.410Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in ratsShahbaa M. Al-khazraji0Medical Technical Institute / Mansour Foundation of Technical EducationGarden cress (Lepidium sativum) seeds are considered extensively in the folk medicine as anantidiabetic agent in many countries. The current investigations focuses attention on theglucose and lipid lowering effect of the aqueous extract of L. sativum seeds on experimentally induced diabetes in rats. The biochemical parameters studied were plasma glucose, insulin, totalcholesterol,triglycerides,phospholipids,hemoglobin, and glycosylated hemoglobin. In addition body weight and renal glucose reabsorption were notified. Aqueous extract of L. sativum were orally administered daily for 30 days in a dose of 20 mg / kg body weight to alloxan – diabetic rats , and a significant reduction in the parameters measured was investigated compared to diabetic rats. Meanwhile, Glibinclamide was used as standard reference drug. In cznclusion , L. sativum seeds possess a hypoglycaemic with concurrent hypolipidemic effect in diabetic states , and may further suggests thatL. Sativum may be useful in the therapy andmanagements of diabetic hyperlipidemia through reducing lipids levels .https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/410Alloxan , diabetes mellitus , hyperlipidemia , Lepidium sativum |
| spellingShingle | Shahbaa M. Al-khazraji Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in rats The Iraqi Journal of Veterinary Medicine Alloxan , diabetes mellitus , hyperlipidemia , Lepidium sativum |
| title | Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in rats |
| title_full | Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in rats |
| title_fullStr | Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in rats |
| title_full_unstemmed | Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in rats |
| title_short | Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in rats |
| title_sort | biopharmacological studies of the aqueous extract of lepidium sativum seeds in alloxan induced diabetes in rats |
| topic | Alloxan , diabetes mellitus , hyperlipidemia , Lepidium sativum |
| url | https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/410 |
| work_keys_str_mv | AT shahbaamalkhazraji biopharmacologicalstudiesoftheaqueousextractoflepidiumsativumseedsinalloxaninduceddiabetesinrats |