A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor
Herbal medicine has been widely used in the treatment of various diseases; however, the adverse reactions cannot be ignored. Most previous studies have ignored the relationship between the factors of geographical areas/batches and toxicity. This study used Polygonum multiflorum (PM) as an example to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00349/full |
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| author | Longfei Lin Hui Li Hongmei Lin Miao Zhang Changhai Qu Lei Yan Xingbin Yin Jian Ni |
| author_facet | Longfei Lin Hui Li Hongmei Lin Miao Zhang Changhai Qu Lei Yan Xingbin Yin Jian Ni |
| author_sort | Longfei Lin |
| collection | DOAJ |
| description | Herbal medicine has been widely used in the treatment of various diseases; however, the adverse reactions cannot be ignored. Most previous studies have ignored the relationship between the factors of geographical areas/batches and toxicity. This study used Polygonum multiflorum (PM) as an example to analyze the relationship between the geographical areas/batches and toxicity and speculated on the hepatotoxicity-inducing components in PM based on high content screening, UHPLC-Q-TOF/MS and Progenesis QI software analysis. The results of the study show that the toxicity of PM was obviously different among the different geographical areas, and the most toxic PM was from the Sichuan province. To obtain more accurate results and to reduce the false-positive rate, two methods were used to evaluate the speculative results. It was noteworthy that emodin was not the main hepatocyte toxicity constituent of PM. The analysis methods suggested that PM toxicity may be associated with tetrahydroxystilbene-O-(galloyl)-hex and emodin-O-hex-sulfate. The toxicity of these two components requires further study. |
| first_indexed | 2024-12-13T00:52:06Z |
| format | Article |
| id | doaj.art-0b012dd13ce140fe9b8c227e92caf27c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T00:52:06Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0b012dd13ce140fe9b8c227e92caf27c2022-12-22T00:04:54ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122017-06-01810.3389/fphar.2017.00349258463A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory FactorLongfei Lin0Hui Li1Hongmei Lin2Miao Zhang3Changhai Qu4Lei Yan5Xingbin Yin6Jian Ni7Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesBeijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical SciencesBeijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese MedicineBeijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese MedicineBeijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese MedicineBeijing, ChinaFengtai District Community Health CenterBeijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese MedicineBeijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese MedicineBeijing, ChinaHerbal medicine has been widely used in the treatment of various diseases; however, the adverse reactions cannot be ignored. Most previous studies have ignored the relationship between the factors of geographical areas/batches and toxicity. This study used Polygonum multiflorum (PM) as an example to analyze the relationship between the geographical areas/batches and toxicity and speculated on the hepatotoxicity-inducing components in PM based on high content screening, UHPLC-Q-TOF/MS and Progenesis QI software analysis. The results of the study show that the toxicity of PM was obviously different among the different geographical areas, and the most toxic PM was from the Sichuan province. To obtain more accurate results and to reduce the false-positive rate, two methods were used to evaluate the speculative results. It was noteworthy that emodin was not the main hepatocyte toxicity constituent of PM. The analysis methods suggested that PM toxicity may be associated with tetrahydroxystilbene-O-(galloyl)-hex and emodin-O-hex-sulfate. The toxicity of these two components requires further study.http://journal.frontiersin.org/article/10.3389/fphar.2017.00349/fullPolygonum multiflorumtoxicitygeographical areasPCAUPLC-Q-TOF/MS |
| spellingShingle | Longfei Lin Hui Li Hongmei Lin Miao Zhang Changhai Qu Lei Yan Xingbin Yin Jian Ni A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor Frontiers in Pharmacology Polygonum multiflorum toxicity geographical areas PCA UPLC-Q-TOF/MS |
| title | A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor |
| title_full | A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor |
| title_fullStr | A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor |
| title_full_unstemmed | A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor |
| title_short | A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor |
| title_sort | new perspective on liver injury by traditional chinese herbs such as polygonum multiflorum the geographical area of harvest as an important contributory factor |
| topic | Polygonum multiflorum toxicity geographical areas PCA UPLC-Q-TOF/MS |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00349/full |
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