Clinical features and mortality in COVID-19 SARI versus non COVID-19 SARI cases from Western Rajasthan, India
Background: In March 2020, the Indian Council of Medical Research (ICMR) issued guidelines that all patients presenting with severe acute respiratory infections (SARI) should be investigated for coronavirus disease 2019 (COVID-19). Following the same protocol, in our institute, all patients with SAR...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=9;spage=3240;epage=3246;aulast=Sharma |
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| author | Ankur Sharma Nikhil Kothari Akhil Dhanesh Goel Balakrishnan Narayanan Shilpa Goyal Pradeep Bhatia Deepak Kumar Gopal Krishna Bohra Nishant Kumar Chauhan Ramniwas Jalandra Naveen Dutt Pankaj Bhardwaj Mahendra Kumar Garg Sanjeev Misra |
| author_facet | Ankur Sharma Nikhil Kothari Akhil Dhanesh Goel Balakrishnan Narayanan Shilpa Goyal Pradeep Bhatia Deepak Kumar Gopal Krishna Bohra Nishant Kumar Chauhan Ramniwas Jalandra Naveen Dutt Pankaj Bhardwaj Mahendra Kumar Garg Sanjeev Misra |
| author_sort | Ankur Sharma |
| collection | DOAJ |
| description | Background: In March 2020, the Indian Council of Medical Research (ICMR) issued guidelines that all patients presenting with severe acute respiratory infections (SARI) should be investigated for coronavirus disease 2019 (COVID-19). Following the same protocol, in our institute, all patients with SARI were transferred to the COVID-19 suspect intensive care unit (ICU) and investigated for COVID-19. Methods: This study was planned to examine the demographical, clinical features, and outcomes of the first 500 suspected patients of COVID-19 with SARI admitted in the COVID-19 suspect ICU at a tertiary care center. Between March 7 and July 20, 2020, 500 patients were admitted to the COVID-19 suspect ICU. We analyzed the demographical, clinical features, and outcomes between COVID-19 positive and negative SARI cases. The records of all the patients were reviewed until July 31, 2020. Results: Of the 500 suspected patients admitted to the hospital, 88 patients showed positive results for COVID-19 by reverse transcription-polymerase chain reaction (RT-PCR) of the nasopharyngeal swabs. The mean age in the positive group was higher (55.31 ± 16.16 years) than in the negative group (40.46 ± 17.49 years) (P < 0.001). Forty-seven (53.4%) of these patients in the COVID-19 positive group and 217 (52.7%) from the negative group suffered from previously known comorbidities. The common symptoms included fever, cough, sore throat, and dyspnea. Eighty-five (20.6%) patients died in the COVID-19 negative group, and 30 (34.1%) died in the COVID-19 positive group (P = 0.006). Deaths among the COVID-19 positive group had a significantly higher age than deaths in the COVID-19 negative group (P < 0.001). Among the patients who died with positive COVID-19 status had substantially higher neutrophilia and lymphopenia (P < 0.001). X-ray chest abnormalities were almost three times more likely in COVID-19 deaths (P < 0.001). Conclusion: In the present article, 17.6% of SARI were due to COVID-19 infection with significantly higher mortality (34.1%) in COVID-19 positive patients with SARI. Although all patients presenting as SARI have considerable mortality rates, the COVID-19-associated SARI cases thus had an almost one-third risk of mortality. |
| first_indexed | 2024-12-21T01:32:17Z |
| format | Article |
| id | doaj.art-0b0150fc86a24f3d928a080b341cedd1 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-21T01:32:17Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-0b0150fc86a24f3d928a080b341cedd12022-12-21T19:20:19ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632021-01-011093240324610.4103/jfmpc.jfmpc_14_21Clinical features and mortality in COVID-19 SARI versus non COVID-19 SARI cases from Western Rajasthan, IndiaAnkur SharmaNikhil KothariAkhil Dhanesh GoelBalakrishnan NarayananShilpa GoyalPradeep BhatiaDeepak KumarGopal Krishna BohraNishant Kumar ChauhanRamniwas JalandraNaveen DuttPankaj BhardwajMahendra Kumar GargSanjeev MisraBackground: In March 2020, the Indian Council of Medical Research (ICMR) issued guidelines that all patients presenting with severe acute respiratory infections (SARI) should be investigated for coronavirus disease 2019 (COVID-19). Following the same protocol, in our institute, all patients with SARI were transferred to the COVID-19 suspect intensive care unit (ICU) and investigated for COVID-19. Methods: This study was planned to examine the demographical, clinical features, and outcomes of the first 500 suspected patients of COVID-19 with SARI admitted in the COVID-19 suspect ICU at a tertiary care center. Between March 7 and July 20, 2020, 500 patients were admitted to the COVID-19 suspect ICU. We analyzed the demographical, clinical features, and outcomes between COVID-19 positive and negative SARI cases. The records of all the patients were reviewed until July 31, 2020. Results: Of the 500 suspected patients admitted to the hospital, 88 patients showed positive results for COVID-19 by reverse transcription-polymerase chain reaction (RT-PCR) of the nasopharyngeal swabs. The mean age in the positive group was higher (55.31 ± 16.16 years) than in the negative group (40.46 ± 17.49 years) (P < 0.001). Forty-seven (53.4%) of these patients in the COVID-19 positive group and 217 (52.7%) from the negative group suffered from previously known comorbidities. The common symptoms included fever, cough, sore throat, and dyspnea. Eighty-five (20.6%) patients died in the COVID-19 negative group, and 30 (34.1%) died in the COVID-19 positive group (P = 0.006). Deaths among the COVID-19 positive group had a significantly higher age than deaths in the COVID-19 negative group (P < 0.001). Among the patients who died with positive COVID-19 status had substantially higher neutrophilia and lymphopenia (P < 0.001). X-ray chest abnormalities were almost three times more likely in COVID-19 deaths (P < 0.001). Conclusion: In the present article, 17.6% of SARI were due to COVID-19 infection with significantly higher mortality (34.1%) in COVID-19 positive patients with SARI. Although all patients presenting as SARI have considerable mortality rates, the COVID-19-associated SARI cases thus had an almost one-third risk of mortality.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=9;spage=3240;epage=3246;aulast=Sharmacoronavirus disease 2019sars-cov2severe acute respiratory infection |
| spellingShingle | Ankur Sharma Nikhil Kothari Akhil Dhanesh Goel Balakrishnan Narayanan Shilpa Goyal Pradeep Bhatia Deepak Kumar Gopal Krishna Bohra Nishant Kumar Chauhan Ramniwas Jalandra Naveen Dutt Pankaj Bhardwaj Mahendra Kumar Garg Sanjeev Misra Clinical features and mortality in COVID-19 SARI versus non COVID-19 SARI cases from Western Rajasthan, India Journal of Family Medicine and Primary Care coronavirus disease 2019 sars-cov2 severe acute respiratory infection |
| title | Clinical features and mortality in COVID-19 SARI versus non COVID-19 SARI cases from Western Rajasthan, India |
| title_full | Clinical features and mortality in COVID-19 SARI versus non COVID-19 SARI cases from Western Rajasthan, India |
| title_fullStr | Clinical features and mortality in COVID-19 SARI versus non COVID-19 SARI cases from Western Rajasthan, India |
| title_full_unstemmed | Clinical features and mortality in COVID-19 SARI versus non COVID-19 SARI cases from Western Rajasthan, India |
| title_short | Clinical features and mortality in COVID-19 SARI versus non COVID-19 SARI cases from Western Rajasthan, India |
| title_sort | clinical features and mortality in covid 19 sari versus non covid 19 sari cases from western rajasthan india |
| topic | coronavirus disease 2019 sars-cov2 severe acute respiratory infection |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=9;spage=3240;epage=3246;aulast=Sharma |
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