A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series
To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before and after a personalized exercise intervention. Con...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Pathophysiology |
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| Online Access: | https://www.mdpi.com/1873-149X/31/1/13 |
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| author | Travis Nemkov Francesca Cendali Monika Dzieciatkowska Daniel Stephenson Kirk C. Hansen Catherine M. Jankowski Angelo D’Alessandro Ryan J. Marker |
| author_facet | Travis Nemkov Francesca Cendali Monika Dzieciatkowska Daniel Stephenson Kirk C. Hansen Catherine M. Jankowski Angelo D’Alessandro Ryan J. Marker |
| author_sort | Travis Nemkov |
| collection | DOAJ |
| description | To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before and after a personalized exercise intervention. Consisting of personalized aerobic and resistance exercises, this intervention was associated with significant molecular changes that correlated with improvements in lean mass, appendicular skeletal muscle index (ASMI), and performance in the 400-m walk test (MWT) and sit-to-stand test. These alterations indicated exercise-induced modulation of inflammation and mitochondrial function markers. This case study provides proof-of-principal application for multiomics-based assessments of supervised exercise, thereby supporting this intervention as a feasible and beneficial intervention for PDAC patients to potentially enhance treatment response and patient quality of life. The molecular changes observed here underscore the importance of physical activity in cancer treatment protocols, advocating for the development of accessible multiomics-guided exercise programs for cancer patients. |
| first_indexed | 2024-04-24T17:55:44Z |
| format | Article |
| id | doaj.art-0b0186f221ec4f63b83ecbe9bbe07658 |
| institution | Directory Open Access Journal |
| issn | 1873-149X |
| language | English |
| last_indexed | 2024-04-24T17:55:44Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathophysiology |
| spelling | doaj.art-0b0186f221ec4f63b83ecbe9bbe076582024-03-27T13:59:03ZengMDPI AGPathophysiology1873-149X2024-03-0131116618210.3390/pathophysiology31010013A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case SeriesTravis Nemkov0Francesca Cendali1Monika Dzieciatkowska2Daniel Stephenson3Kirk C. Hansen4Catherine M. Jankowski5Angelo D’Alessandro6Ryan J. Marker7Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USADepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USADepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USADepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USADepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USACollege of Nursing, University of Colorado, Aurora, CO 80045, USADepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USADepartment of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USATo molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before and after a personalized exercise intervention. Consisting of personalized aerobic and resistance exercises, this intervention was associated with significant molecular changes that correlated with improvements in lean mass, appendicular skeletal muscle index (ASMI), and performance in the 400-m walk test (MWT) and sit-to-stand test. These alterations indicated exercise-induced modulation of inflammation and mitochondrial function markers. This case study provides proof-of-principal application for multiomics-based assessments of supervised exercise, thereby supporting this intervention as a feasible and beneficial intervention for PDAC patients to potentially enhance treatment response and patient quality of life. The molecular changes observed here underscore the importance of physical activity in cancer treatment protocols, advocating for the development of accessible multiomics-guided exercise programs for cancer patients.https://www.mdpi.com/1873-149X/31/1/13pancreatic cancerexercise oncologypancreatic adenocarcinomametabolomicslipidomicsproteomics |
| spellingShingle | Travis Nemkov Francesca Cendali Monika Dzieciatkowska Daniel Stephenson Kirk C. Hansen Catherine M. Jankowski Angelo D’Alessandro Ryan J. Marker A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series Pathophysiology pancreatic cancer exercise oncology pancreatic adenocarcinoma metabolomics lipidomics proteomics |
| title | A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series |
| title_full | A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series |
| title_fullStr | A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series |
| title_full_unstemmed | A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series |
| title_short | A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series |
| title_sort | multiomics assessment of preoperative exercise in pancreatic cancer survivors receiving neoadjuvant therapy a case series |
| topic | pancreatic cancer exercise oncology pancreatic adenocarcinoma metabolomics lipidomics proteomics |
| url | https://www.mdpi.com/1873-149X/31/1/13 |
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