Pre-clinical models to study abnormal uterine bleeding (AUB)
Summary: Abnormal Uterine Bleeding (AUB) is a common debilitating condition that significantly reduces quality of life of women across the reproductive age span. AUB creates significant morbidity, medical, social, and economic problems for women, their families, workplace, and health services. Despi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396422004200 |
| _version_ | 1828738373957713920 |
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| author | Aleksandra O. Tsolova Rocío Martínez Aguilar Jacqueline A. Maybin Hilary O.D. Critchley |
| author_facet | Aleksandra O. Tsolova Rocío Martínez Aguilar Jacqueline A. Maybin Hilary O.D. Critchley |
| author_sort | Aleksandra O. Tsolova |
| collection | DOAJ |
| description | Summary: Abnormal Uterine Bleeding (AUB) is a common debilitating condition that significantly reduces quality of life of women across the reproductive age span. AUB creates significant morbidity, medical, social, and economic problems for women, their families, workplace, and health services. Despite the profoundly negative effects of AUB on public health, advancement in understanding the pathophysiology of AUB and the discovery of novel effective therapies is slow due to lack of reliable pre-clinical models.This review discusses currently available laboratory-based pre-clinical scientific models and how they are used to study AUB. Human and animal in vitro, ex vivo, and in vivo models will be described along with advantages and limitations of each method. |
| first_indexed | 2024-04-13T00:02:03Z |
| format | Article |
| id | doaj.art-0b0322f2c62044e1bb9bc19a3d662893 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-04-13T00:02:03Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-0b0322f2c62044e1bb9bc19a3d6628932022-12-22T03:11:19ZengElsevierEBioMedicine2352-39642022-10-0184104238Pre-clinical models to study abnormal uterine bleeding (AUB)Aleksandra O. Tsolova0Rocío Martínez Aguilar1Jacqueline A. Maybin2Hilary O.D. Critchley3MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UKMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UKMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UKCorresponding author at: MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UKSummary: Abnormal Uterine Bleeding (AUB) is a common debilitating condition that significantly reduces quality of life of women across the reproductive age span. AUB creates significant morbidity, medical, social, and economic problems for women, their families, workplace, and health services. Despite the profoundly negative effects of AUB on public health, advancement in understanding the pathophysiology of AUB and the discovery of novel effective therapies is slow due to lack of reliable pre-clinical models.This review discusses currently available laboratory-based pre-clinical scientific models and how they are used to study AUB. Human and animal in vitro, ex vivo, and in vivo models will be described along with advantages and limitations of each method.http://www.sciencedirect.com/science/article/pii/S2352396422004200Abnormal uterine bleeding (AUB)EndometriumPre-clinical modelsEpithelial organoidsEndometrial co-culturesAdenomyosis |
| spellingShingle | Aleksandra O. Tsolova Rocío Martínez Aguilar Jacqueline A. Maybin Hilary O.D. Critchley Pre-clinical models to study abnormal uterine bleeding (AUB) EBioMedicine Abnormal uterine bleeding (AUB) Endometrium Pre-clinical models Epithelial organoids Endometrial co-cultures Adenomyosis |
| title | Pre-clinical models to study abnormal uterine bleeding (AUB) |
| title_full | Pre-clinical models to study abnormal uterine bleeding (AUB) |
| title_fullStr | Pre-clinical models to study abnormal uterine bleeding (AUB) |
| title_full_unstemmed | Pre-clinical models to study abnormal uterine bleeding (AUB) |
| title_short | Pre-clinical models to study abnormal uterine bleeding (AUB) |
| title_sort | pre clinical models to study abnormal uterine bleeding aub |
| topic | Abnormal uterine bleeding (AUB) Endometrium Pre-clinical models Epithelial organoids Endometrial co-cultures Adenomyosis |
| url | http://www.sciencedirect.com/science/article/pii/S2352396422004200 |
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