Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis

Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis

Sepsis is the culmination of hyperinflammation and immune suppression in response to severe infection. Neutrophils are critical early responders to bacterial infection but can become highly dysfunctional during sepsis and other inflammatory disorders. The transmembrane protease ADAM17 (a disintegrin...

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Bibliographic Details
Main Authors: Hemant K. Mishra, Jing Ma, Daniel Mendez, Robert Hullsiek, Nabendu Pore, Bruce Walcheck
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
sepsis
ADAM17
inflammation
immunosuppression
neutrophil
Online Access:https://www.mdpi.com/1422-0067/21/18/6688

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