Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing
Abstract Surface‐enhanced Raman scattering (SERS) is a feasible and ultra‐sensitive method for biomedical imaging and disease diagnosis. SERS is widely applied to in vivo imaging due to the development of functional nanoparticles encoded by Raman active molecules (SERS nanoprobes) and improvements i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202202051 |
| _version_ | 1827989660666691584 |
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| author | Qingqing Li Hongqi Huo Ying Wu Lanlan Chen Lichao Su Xuan Zhang Jibin Song Huanghao Yang |
| author_facet | Qingqing Li Hongqi Huo Ying Wu Lanlan Chen Lichao Su Xuan Zhang Jibin Song Huanghao Yang |
| author_sort | Qingqing Li |
| collection | DOAJ |
| description | Abstract Surface‐enhanced Raman scattering (SERS) is a feasible and ultra‐sensitive method for biomedical imaging and disease diagnosis. SERS is widely applied to in vivo imaging due to the development of functional nanoparticles encoded by Raman active molecules (SERS nanoprobes) and improvements in instruments. Herein, the recent developments in SERS active materials and their in vivo imaging and biosensing applications are overviewed. Various SERS substrates that have been successfully used for in vivo imaging are described. Then, the applications of SERS imaging in cancer detection and in vivo intraoperative guidance are summarized. The role of highly sensitive SERS biosensors in guiding the detection and prevention of diseases is discussed in detail. Moreover, its role in the identification and resection of microtumors and as a diagnostic and therapeutic platform is also reviewed. Finally, the progress and challenges associated with SERS active materials, equipment, and clinical translation are described. The present evidence suggests that SERS could be applied in clinical practice in the future. |
| first_indexed | 2024-04-10T00:23:51Z |
| format | Article |
| id | doaj.art-0b08a5bee734404a98712c6a5e8bd7a2 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-10T00:23:51Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-0b08a5bee734404a98712c6a5e8bd7a22023-03-15T13:19:15ZengWileyAdvanced Science2198-38442023-03-01108n/an/a10.1002/advs.202202051Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and BiosensingQingqing Li0Hongqi Huo1Ying Wu2Lanlan Chen3Lichao Su4Xuan Zhang5Jibin Song6Huanghao Yang7MOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 P. R. ChinaDepartment of Nuclear Medicine Han Dan Central Hospital Handan Hebei 056001 P. R. ChinaMOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 P. R. ChinaMOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 P. R. ChinaMOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 P. R. ChinaMOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 P. R. ChinaMOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 P. R. ChinaMOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 P. R. ChinaAbstract Surface‐enhanced Raman scattering (SERS) is a feasible and ultra‐sensitive method for biomedical imaging and disease diagnosis. SERS is widely applied to in vivo imaging due to the development of functional nanoparticles encoded by Raman active molecules (SERS nanoprobes) and improvements in instruments. Herein, the recent developments in SERS active materials and their in vivo imaging and biosensing applications are overviewed. Various SERS substrates that have been successfully used for in vivo imaging are described. Then, the applications of SERS imaging in cancer detection and in vivo intraoperative guidance are summarized. The role of highly sensitive SERS biosensors in guiding the detection and prevention of diseases is discussed in detail. Moreover, its role in the identification and resection of microtumors and as a diagnostic and therapeutic platform is also reviewed. Finally, the progress and challenges associated with SERS active materials, equipment, and clinical translation are described. The present evidence suggests that SERS could be applied in clinical practice in the future.https://doi.org/10.1002/advs.202202051biosensingdiagnosisRaman mappingself‐assemblysurface‐enhanced Raman scattering |
| spellingShingle | Qingqing Li Hongqi Huo Ying Wu Lanlan Chen Lichao Su Xuan Zhang Jibin Song Huanghao Yang Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing Advanced Science biosensing diagnosis Raman mapping self‐assembly surface‐enhanced Raman scattering |
| title | Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing |
| title_full | Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing |
| title_fullStr | Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing |
| title_full_unstemmed | Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing |
| title_short | Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing |
| title_sort | design and synthesis of sers materials for in vivo molecular imaging and biosensing |
| topic | biosensing diagnosis Raman mapping self‐assembly surface‐enhanced Raman scattering |
| url | https://doi.org/10.1002/advs.202202051 |
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