Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger–Westphal Nucleus in the Rotenone model of Parkinson’s Disease

Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger–Westphal Nucleus in the Rotenone model of Parkinson’s Disease

Numerous in vitro and in vivo models of Parkinson’s disease (PD) demonstrate that pituitary adenylate cyclase-activating polypeptide (PACAP) conveys its strong neuroprotective actions mainly via its specific PAC1 receptor (PAC1R) in models of PD. We recently described the decrease in PAC1R protein c...

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Bibliographic Details
Main Authors: Máté Fehér, Zsombor Márton, Ákos Szabó, János Kocsa, Viktória Kormos, Ágnes Hunyady, László Ákos Kovács, Balázs Ujvári, Gergely Berta, József Farkas, Nóra Füredi, Tamás Gaszner, Bence Pytel, Dóra Reglődi, Balázs Gaszner
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
caudate-putamen
globus pallidus
entopeduncular nucleus
cortex
rotarod
non-motor symptoms of Parkinson’s disease
Online Access:https://www.mdpi.com/1422-0067/24/14/11843

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