Early and late oral features of chronic graft-versus-host disease
Background: Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites. Objective: The aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation. M...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100043&lng=en&tlng=en |
| _version_ | 1819002375286816768 |
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| author | Alessandra Oliveira Ferrari Gomes Sandra Regina Torres Angelo Maiolino Cesar Werneck Noce dos Santos Arley Silva Junior Maria Elvira Pizzigatti Correa Maria Claudia Rodrigues Moreira Lucio de Souza Goncalves |
| author_facet | Alessandra Oliveira Ferrari Gomes Sandra Regina Torres Angelo Maiolino Cesar Werneck Noce dos Santos Arley Silva Junior Maria Elvira Pizzigatti Correa Maria Claudia Rodrigues Moreira Lucio de Souza Goncalves |
| author_sort | Alessandra Oliveira Ferrari Gomes |
| collection | DOAJ |
| description | Background: Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites. Objective: The aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation. Methods: This was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain and xerostomia were evaluated through a visual analogue scale. Patients were divided into two groups based on the transplantation time (up to one year and more than one year). Results: Of the 57 evaluated recipients, 44 had chronic graft-versus-host disease: ten (22.72%) in the group with less than one year after transplantation, and 34 (77.27%) in the group with more than one year after transplantation. Lichenoid/hyperkeratotic plaques, erythematous lesions, xerostomia, and hyposalivation were the most commonly reported oral features. Lichenoid/hyperkeratotic plaques were significantly more common in patients within the first year after the transplant. The labial mucosa was affected more in the first year. No significant changes occurred in the frequency of xerostomia, hyposalivation, and reduced mouth opening regarding time after transplantation. Conclusion: Oral chronic graft-versus-host disease lesions were identified early in the course of the disease. The changes observed in salivary gland function and in the range of mouth opening were not correlated with the time after transplantation. |
| first_indexed | 2024-12-20T23:04:06Z |
| format | Article |
| id | doaj.art-0b0983f56f4247639762a9bdf69447c8 |
| institution | Directory Open Access Journal |
| issn | 1806-0870 |
| language | English |
| last_indexed | 2024-12-20T23:04:06Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-0b0983f56f4247639762a9bdf69447c82022-12-21T19:23:54ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-08702014-01-01361434910.5581/1516-8484.20140012S1516-84842014000100043Early and late oral features of chronic graft-versus-host diseaseAlessandra Oliveira Ferrari GomesSandra Regina TorresAngelo MaiolinoCesar Werneck Noce dos SantosArley Silva JuniorMaria Elvira Pizzigatti CorreaMaria Claudia Rodrigues MoreiraLucio de Souza GoncalvesBackground: Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites. Objective: The aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation. Methods: This was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain and xerostomia were evaluated through a visual analogue scale. Patients were divided into two groups based on the transplantation time (up to one year and more than one year). Results: Of the 57 evaluated recipients, 44 had chronic graft-versus-host disease: ten (22.72%) in the group with less than one year after transplantation, and 34 (77.27%) in the group with more than one year after transplantation. Lichenoid/hyperkeratotic plaques, erythematous lesions, xerostomia, and hyposalivation were the most commonly reported oral features. Lichenoid/hyperkeratotic plaques were significantly more common in patients within the first year after the transplant. The labial mucosa was affected more in the first year. No significant changes occurred in the frequency of xerostomia, hyposalivation, and reduced mouth opening regarding time after transplantation. Conclusion: Oral chronic graft-versus-host disease lesions were identified early in the course of the disease. The changes observed in salivary gland function and in the range of mouth opening were not correlated with the time after transplantation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100043&lng=en&tlng=enChronic diseaseHematopoietic stem cell transplantationDiagnosis, oralGraft-versus-host disease |
| spellingShingle | Alessandra Oliveira Ferrari Gomes Sandra Regina Torres Angelo Maiolino Cesar Werneck Noce dos Santos Arley Silva Junior Maria Elvira Pizzigatti Correa Maria Claudia Rodrigues Moreira Lucio de Souza Goncalves Early and late oral features of chronic graft-versus-host disease Revista Brasileira de Hematologia e Hemoterapia Chronic disease Hematopoietic stem cell transplantation Diagnosis, oral Graft-versus-host disease |
| title | Early and late oral features of chronic graft-versus-host disease |
| title_full | Early and late oral features of chronic graft-versus-host disease |
| title_fullStr | Early and late oral features of chronic graft-versus-host disease |
| title_full_unstemmed | Early and late oral features of chronic graft-versus-host disease |
| title_short | Early and late oral features of chronic graft-versus-host disease |
| title_sort | early and late oral features of chronic graft versus host disease |
| topic | Chronic disease Hematopoietic stem cell transplantation Diagnosis, oral Graft-versus-host disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100043&lng=en&tlng=en |
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