Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction
Abstract Background This study aimed to investigate the effect of glycemic variability (GV), determined using a continuous glucose monitoring system (CGMS), on left ventricular reverse remodeling (LVRR) after ST-segment elevation myocardial infarction (STEMI). Methods A total of 201 consecutive pati...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-01931-3 |
| _version_ | 1797453992958099456 |
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| author | Yohei Hanajima Noriaki Iwahashi Jin Kirigaya Mutsuo Horii Yugo Minamimoto Masaomi Gohbara Takeru Abe Kozo Okada Yasushi Matsuzawa Masami Kosuge Toshiaki Ebina Kiyoshi Hibi |
| author_facet | Yohei Hanajima Noriaki Iwahashi Jin Kirigaya Mutsuo Horii Yugo Minamimoto Masaomi Gohbara Takeru Abe Kozo Okada Yasushi Matsuzawa Masami Kosuge Toshiaki Ebina Kiyoshi Hibi |
| author_sort | Yohei Hanajima |
| collection | DOAJ |
| description | Abstract Background This study aimed to investigate the effect of glycemic variability (GV), determined using a continuous glucose monitoring system (CGMS), on left ventricular reverse remodeling (LVRR) after ST-segment elevation myocardial infarction (STEMI). Methods A total of 201 consecutive patients with STEMI who underwent reperfusion therapy within 12 h of onset were enrolled. GV was measured using a CGMS and determined as the mean amplitude of glycemic excursion (MAGE). Left ventricular volumetric parameters were measured using cardiac magnetic resonance imaging (CMRI). LVRR was defined as an absolute decrease in the LV end-systolic volume index of > 10% from 1 week to 7 months after admission. Associations were also examined between GV and LVRR and between LVRR and the incidence of major adverse cardiovascular events (MACE; cardiovascular death, acute coronary syndrome recurrence, non-fatal stroke, and heart failure hospitalization). Results The prevalence of LVRR was 28% (n = 57). The MAGE was independent predictor of LVRR (odds ratio [OR] 0.98, p = 0.002). Twenty patients experienced MACE during the follow-up period (median, 65 months). The incidence of MACE was lower in patients with LVRR than in those without (2% vs. 13%, p = 0.016). Conclusion Low GV, determined using a CGMS, was significantly associated with LVRR, which might lead to a good prognosis. Further studies are needed to validate the importance of GV in LVRR in patients with STEMI. |
| first_indexed | 2024-03-09T15:30:49Z |
| format | Article |
| id | doaj.art-0b0a04a079f844c690a731118bdfcc1d |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-09T15:30:49Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-0b0a04a079f844c690a731118bdfcc1d2023-11-26T12:15:25ZengBMCCardiovascular Diabetology1475-28402023-08-0122111010.1186/s12933-023-01931-3Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarctionYohei Hanajima0Noriaki Iwahashi1Jin Kirigaya2Mutsuo Horii3Yugo Minamimoto4Masaomi Gohbara5Takeru Abe6Kozo Okada7Yasushi Matsuzawa8Masami Kosuge9Toshiaki Ebina10Kiyoshi Hibi11Division of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDepartment of Quality and Safety in Healthcare, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterDivision of Cardiology, Yokohama City University Medical CenterAbstract Background This study aimed to investigate the effect of glycemic variability (GV), determined using a continuous glucose monitoring system (CGMS), on left ventricular reverse remodeling (LVRR) after ST-segment elevation myocardial infarction (STEMI). Methods A total of 201 consecutive patients with STEMI who underwent reperfusion therapy within 12 h of onset were enrolled. GV was measured using a CGMS and determined as the mean amplitude of glycemic excursion (MAGE). Left ventricular volumetric parameters were measured using cardiac magnetic resonance imaging (CMRI). LVRR was defined as an absolute decrease in the LV end-systolic volume index of > 10% from 1 week to 7 months after admission. Associations were also examined between GV and LVRR and between LVRR and the incidence of major adverse cardiovascular events (MACE; cardiovascular death, acute coronary syndrome recurrence, non-fatal stroke, and heart failure hospitalization). Results The prevalence of LVRR was 28% (n = 57). The MAGE was independent predictor of LVRR (odds ratio [OR] 0.98, p = 0.002). Twenty patients experienced MACE during the follow-up period (median, 65 months). The incidence of MACE was lower in patients with LVRR than in those without (2% vs. 13%, p = 0.016). Conclusion Low GV, determined using a CGMS, was significantly associated with LVRR, which might lead to a good prognosis. Further studies are needed to validate the importance of GV in LVRR in patients with STEMI.https://doi.org/10.1186/s12933-023-01931-3Acute myocardial infarctionContinuous glucose monitoring systemGlucoseGlycemic variabilityRemodeling |
| spellingShingle | Yohei Hanajima Noriaki Iwahashi Jin Kirigaya Mutsuo Horii Yugo Minamimoto Masaomi Gohbara Takeru Abe Kozo Okada Yasushi Matsuzawa Masami Kosuge Toshiaki Ebina Kiyoshi Hibi Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction Cardiovascular Diabetology Acute myocardial infarction Continuous glucose monitoring system Glucose Glycemic variability Remodeling |
| title | Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction |
| title_full | Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction |
| title_fullStr | Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction |
| title_full_unstemmed | Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction |
| title_short | Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction |
| title_sort | prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of st segment elevation myocardial infarction |
| topic | Acute myocardial infarction Continuous glucose monitoring system Glucose Glycemic variability Remodeling |
| url | https://doi.org/10.1186/s12933-023-01931-3 |
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