Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis
Since the highly conserved exosome complex mediates the degradation and processing of multiple classes of RNAs, it almost certainly controls diverse biological processes. How this post-transcriptional RNA-regulatory machine impacts cell fate decisions and differentiation is poorly understood. Previo...
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| Format: | Article |
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eLife Sciences Publications Ltd
2016-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/17877 |
| _version_ | 1811227822575845376 |
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| author | Skye C McIver Koichi R Katsumura Elsa Davids Peng Liu Yoon-A Kang David Yang Emery H Bresnick |
| author_facet | Skye C McIver Koichi R Katsumura Elsa Davids Peng Liu Yoon-A Kang David Yang Emery H Bresnick |
| author_sort | Skye C McIver |
| collection | DOAJ |
| description | Since the highly conserved exosome complex mediates the degradation and processing of multiple classes of RNAs, it almost certainly controls diverse biological processes. How this post-transcriptional RNA-regulatory machine impacts cell fate decisions and differentiation is poorly understood. Previously, we demonstrated that exosome complex subunits confer an erythroid maturation barricade, and the erythroid transcription factor GATA-1 dismantles the barricade by transcriptionally repressing the cognate genes. While dissecting requirements for the maturation barricade in Mus musculus, we discovered that the exosome complex is a vital determinant of a developmental signaling transition that dictates proliferation/amplification versus differentiation. Exosome complex integrity in erythroid precursor cells ensures Kit receptor tyrosine kinase expression and stem cell factor/Kit signaling, while preventing responsiveness to erythropoietin-instigated signals that promote differentiation. Functioning as a gatekeeper of this developmental signaling transition, the exosome complex controls the massive production of erythroid cells that ensures organismal survival in homeostatic and stress contexts. |
| first_indexed | 2024-04-12T09:48:24Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:48:24Z |
| publishDate | 2016-08-01 |
| publisher | eLife Sciences Publications Ltd |
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| spelling | doaj.art-0b0c354fd42a4b9fb57ef515924e64c22022-12-22T03:37:53ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.17877Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesisSkye C McIver0Koichi R Katsumura1Elsa Davids2Peng Liu3Yoon-A Kang4David Yang5Emery H Bresnick6https://orcid.org/0000-0002-1151-5654Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States; UW-Madison Blood Research Program, University of Wisconsin School of Medicine and Public Health, Madison, United States; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, United StatesDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States; UW-Madison Blood Research Program, University of Wisconsin School of Medicine and Public Health, Madison, United States; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, United StatesDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States; UW-Madison Blood Research Program, University of Wisconsin School of Medicine and Public Health, Madison, United States; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, United StatesCarbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, United States; Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, United StatesDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States; UW-Madison Blood Research Program, University of Wisconsin School of Medicine and Public Health, Madison, United States; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, United StatesDepartment of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, United StatesDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, United States; UW-Madison Blood Research Program, University of Wisconsin School of Medicine and Public Health, Madison, United States; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, United StatesSince the highly conserved exosome complex mediates the degradation and processing of multiple classes of RNAs, it almost certainly controls diverse biological processes. How this post-transcriptional RNA-regulatory machine impacts cell fate decisions and differentiation is poorly understood. Previously, we demonstrated that exosome complex subunits confer an erythroid maturation barricade, and the erythroid transcription factor GATA-1 dismantles the barricade by transcriptionally repressing the cognate genes. While dissecting requirements for the maturation barricade in Mus musculus, we discovered that the exosome complex is a vital determinant of a developmental signaling transition that dictates proliferation/amplification versus differentiation. Exosome complex integrity in erythroid precursor cells ensures Kit receptor tyrosine kinase expression and stem cell factor/Kit signaling, while preventing responsiveness to erythropoietin-instigated signals that promote differentiation. Functioning as a gatekeeper of this developmental signaling transition, the exosome complex controls the massive production of erythroid cells that ensures organismal survival in homeostatic and stress contexts.https://elifesciences.org/articles/17877erythroidprogenitorsignalingtranscription |
| spellingShingle | Skye C McIver Koichi R Katsumura Elsa Davids Peng Liu Yoon-A Kang David Yang Emery H Bresnick Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis eLife erythroid progenitor signaling transcription |
| title | Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis |
| title_full | Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis |
| title_fullStr | Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis |
| title_full_unstemmed | Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis |
| title_short | Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis |
| title_sort | exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis |
| topic | erythroid progenitor signaling transcription |
| url | https://elifesciences.org/articles/17877 |
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