Adapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targeting

Adapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targeting

Despite the recent success of CAR T cells targeting CD19 and CD22 in hematological malignancies, the production of CAR T cells still requires an extensive manufacturing process. The well-established NK-92 cell line provides a promising alternative to produce CAR-modified effector cells in a GMP-comp...

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Bibliographic Details
Main Authors: Stefan Grote, Joerg Mittelstaet, Caroline Baden, Kenneth Chun-Ho Chan, Christian Seitz, Patrick Schlegel, Andrew Kaiser, Rupert Handgretinger, Sabine Schleicher
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
nk-92
chimeric antigen receptors
universal tumor targeting
adapter
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1825177

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