Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein expression predicts disease severity in nonalcoholic steatohepatitis patients
Abstract The role of Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA+‐M2BP) in the prediction of disease severity in nonalcoholic fatty liver disease (NAFLD) remains elusive. This study evaluated the performance of WFA+‐M2BP in predicting fibrosis in patients with NAFLD. A total o...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/kjm2.12474 |
| _version_ | 1828487761488773120 |
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| author | Tyng‐Yuan Jang Chung‐Feng Huang Ming‐Lun Yeh Ching‐I Huang Chia‐Yen Dai Pei‐Chien Tsai Po‐Yau Hsu Yi‐Ju Wei Nai‐Jen Hou Po‐Cheng Liang Yi‐Hung Lin Chih‐Wen Wang Ming‐Yen Hsieh Zu‐Yau Lin Jee‐Fu Huang Ming‐Lung Yu Wan‐Long Chuang |
| author_facet | Tyng‐Yuan Jang Chung‐Feng Huang Ming‐Lun Yeh Ching‐I Huang Chia‐Yen Dai Pei‐Chien Tsai Po‐Yau Hsu Yi‐Ju Wei Nai‐Jen Hou Po‐Cheng Liang Yi‐Hung Lin Chih‐Wen Wang Ming‐Yen Hsieh Zu‐Yau Lin Jee‐Fu Huang Ming‐Lung Yu Wan‐Long Chuang |
| author_sort | Tyng‐Yuan Jang |
| collection | DOAJ |
| description | Abstract The role of Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA+‐M2BP) in the prediction of disease severity in nonalcoholic fatty liver disease (NAFLD) remains elusive. This study evaluated the performance of WFA+‐M2BP in predicting fibrosis in patients with NAFLD. A total of 80 patients with biopsy‐proven nonalcoholic steatohepatitis (NASH) were enrolled. Serum WFA+‐M2BP levels were measured using standard methods. The fibrosis‐4 (FIB‐4) index was also measured. The mean values of WFA+‐M2BP were 1.0, 1.0, 0.8, and 2.2 in Metavir fibrosis stage F0, F1, F2, and F3‐4, respectively (linear trend p = 0.005). The optimal cut‐off value of WFA+‐M2BP in predicting advanced fibrosis (F3‐4) was 1.37 cut‐off index (COI), yielding the sensitivity, specificity, positive predictive value (PPV), negative predictive value, and accuracy of 75.0, 79.4, 39.1, 94.7, and 78.7%, respectively (p < 0.001). Combining WFA+‐M2BP with FIB‐4 significantly increased the diagnostic performance for advanced fibrosis, yielding specificity, PPV, and accuracy of 100, 100, and 93%, respectively. The significant factors predicting advanced liver fibrosis in the multivariate regression analysis were WFA+‐M2BP ≥ 1.37 COI (OR/confidence interval [CI]: 9.49/1.63–55.21, p = 0.01) and FIB‐4 ≥ 2.80 (OR/CI: 38.18/4.89–297.93, p = 0.001). Monitoring WFA+‐M2BP is suitable for noninvasive assessment of liver fibrosis in NASH patients, particularly in combination with FIB‐4. |
| first_indexed | 2024-12-11T09:57:44Z |
| format | Article |
| id | doaj.art-0b0e8b05b7cb40e0bc5b866e021cc608 |
| institution | Directory Open Access Journal |
| issn | 1607-551X 2410-8650 |
| language | English |
| last_indexed | 2024-12-11T09:57:44Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-0b0e8b05b7cb40e0bc5b866e021cc6082022-12-22T01:12:13ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502022-03-0138326126710.1002/kjm2.12474Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein expression predicts disease severity in nonalcoholic steatohepatitis patientsTyng‐Yuan Jang0Chung‐Feng Huang1Ming‐Lun Yeh2Ching‐I Huang3Chia‐Yen Dai4Pei‐Chien Tsai5Po‐Yau Hsu6Yi‐Ju Wei7Nai‐Jen Hou8Po‐Cheng Liang9Yi‐Hung Lin10Chih‐Wen Wang11Ming‐Yen Hsieh12Zu‐Yau Lin13Jee‐Fu Huang14Ming‐Lung Yu15Wan‐Long Chuang16Hepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Internal Medicine Kaohsiung Municipal Ta‐Tung Hospital Kaohsiung TaiwanDepartment of Internal Medicine Kaohsiung Municipal Ta‐Tung Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Internal Medicine Kaohsiung Municipal Ta‐Tung Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division and Hepatitis Center, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanAbstract The role of Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA+‐M2BP) in the prediction of disease severity in nonalcoholic fatty liver disease (NAFLD) remains elusive. This study evaluated the performance of WFA+‐M2BP in predicting fibrosis in patients with NAFLD. A total of 80 patients with biopsy‐proven nonalcoholic steatohepatitis (NASH) were enrolled. Serum WFA+‐M2BP levels were measured using standard methods. The fibrosis‐4 (FIB‐4) index was also measured. The mean values of WFA+‐M2BP were 1.0, 1.0, 0.8, and 2.2 in Metavir fibrosis stage F0, F1, F2, and F3‐4, respectively (linear trend p = 0.005). The optimal cut‐off value of WFA+‐M2BP in predicting advanced fibrosis (F3‐4) was 1.37 cut‐off index (COI), yielding the sensitivity, specificity, positive predictive value (PPV), negative predictive value, and accuracy of 75.0, 79.4, 39.1, 94.7, and 78.7%, respectively (p < 0.001). Combining WFA+‐M2BP with FIB‐4 significantly increased the diagnostic performance for advanced fibrosis, yielding specificity, PPV, and accuracy of 100, 100, and 93%, respectively. The significant factors predicting advanced liver fibrosis in the multivariate regression analysis were WFA+‐M2BP ≥ 1.37 COI (OR/confidence interval [CI]: 9.49/1.63–55.21, p = 0.01) and FIB‐4 ≥ 2.80 (OR/CI: 38.18/4.89–297.93, p = 0.001). Monitoring WFA+‐M2BP is suitable for noninvasive assessment of liver fibrosis in NASH patients, particularly in combination with FIB‐4.https://doi.org/10.1002/kjm2.12474FIB‐4liver fibrosisNASHWFA+‐M2BP |
| spellingShingle | Tyng‐Yuan Jang Chung‐Feng Huang Ming‐Lun Yeh Ching‐I Huang Chia‐Yen Dai Pei‐Chien Tsai Po‐Yau Hsu Yi‐Ju Wei Nai‐Jen Hou Po‐Cheng Liang Yi‐Hung Lin Chih‐Wen Wang Ming‐Yen Hsieh Zu‐Yau Lin Jee‐Fu Huang Ming‐Lung Yu Wan‐Long Chuang Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein expression predicts disease severity in nonalcoholic steatohepatitis patients Kaohsiung Journal of Medical Sciences FIB‐4 liver fibrosis NASH WFA+‐M2BP |
| title | Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein expression predicts disease severity in nonalcoholic steatohepatitis patients |
| title_full | Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein expression predicts disease severity in nonalcoholic steatohepatitis patients |
| title_fullStr | Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein expression predicts disease severity in nonalcoholic steatohepatitis patients |
| title_full_unstemmed | Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein expression predicts disease severity in nonalcoholic steatohepatitis patients |
| title_short | Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein expression predicts disease severity in nonalcoholic steatohepatitis patients |
| title_sort | serum wisteria floribunda agglutinin positive mac 2 binding protein expression predicts disease severity in nonalcoholic steatohepatitis patients |
| topic | FIB‐4 liver fibrosis NASH WFA+‐M2BP |
| url | https://doi.org/10.1002/kjm2.12474 |
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