Effect of United States buckwheat honey on antibiotic-resistant hospital acquired pathogens
INTRODUCTION: due to an upsurge in antibiotic-resistant infections and lack of therapeutic options, new approaches are needed for treatment. Honey may be one such potential therapeutic option. We investigated the susceptibility of hospital acquired pathogens to four honeys from Wisconsin, United Sta...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2016-12-01
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| Series: | The Pan African Medical Journal |
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https://www.panafrican-med-journal.com/content/article/25/212/pdf/212.pdf
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| _version_ | 1818978003138379776 |
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| author | Eric Nee-Armah Hammond Megan Duster Jackson Ssentalo Musuuza Nasia Safdar |
| author_facet | Eric Nee-Armah Hammond Megan Duster Jackson Ssentalo Musuuza Nasia Safdar |
| author_sort | Eric Nee-Armah Hammond |
| collection | DOAJ |
| description | INTRODUCTION: due to an upsurge in antibiotic-resistant infections and lack of therapeutic options, new approaches are needed for treatment. Honey may be one such potential therapeutic option. We investigated the susceptibility of hospital acquired pathogens to four honeys from Wisconsin, United States, and then determined if the antibacterial effect ofeach honey against these pathogensis primarily due to the high sugar content. METHODS: thirteen pathogens including: four Clostridium difficile, two Methicillin-resistant Staphylococcus aureus, two Pseudomonas aeruginosa, one Methicillin-Susceptible Staphylococcus aureus, twoVancomycin-resistance Enterococcus, one Enterococcusfaecalis and one Klebsiella pneumonia were exposed to 1-50% (w/v) four Wisconsin honeys and Artificial honey to determine their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) using the broth dilution method. RESULTS: buckwheathoney predominantly exhibited a bactericidal mode of action against the tested pathogens, and this varied with each pathogen. C. difficile isolates were more sensitive to the Wisconsin buckwheat honeyas compared to the other pathogens. Artificial honey at 50% (w/v) failed to kill any of the pathogens. The high sugar content of Wisconsin buckwheat honey is not the only factor responsible for its bactericidal activity. CONCLUSION: Wisconsin buckwheat honeyhas the potential to be an important addition to therapeutic armamentarium against resistant pathogens and should be investigated further. |
| first_indexed | 2024-12-20T16:36:43Z |
| format | Article |
| id | doaj.art-0b0ff07a33b54f89ae7903ddaac38832 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-20T16:36:43Z |
| publishDate | 2016-12-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-0b0ff07a33b54f89ae7903ddaac388322022-12-21T19:33:08ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882016-12-012521210.11604/pamj.2016.25.212.1041410414Effect of United States buckwheat honey on antibiotic-resistant hospital acquired pathogensEric Nee-Armah Hammond0Megan Duster1Jackson Ssentalo Musuuza2Nasia Safdar3 Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI 53705, USA Division of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison,WI 53705, USA, 3William S. Middleton Memorial VA Medical Center, Madison WI 53705, USA Division of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison,WI 53705, USA, 3William S. Middleton Memorial VA Medical Center, Madison WI 53705, USA Division of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison,WI 53705, USA, 3William S. Middleton Memorial VA Medical Center, Madison WI 53705, USA INTRODUCTION: due to an upsurge in antibiotic-resistant infections and lack of therapeutic options, new approaches are needed for treatment. Honey may be one such potential therapeutic option. We investigated the susceptibility of hospital acquired pathogens to four honeys from Wisconsin, United States, and then determined if the antibacterial effect ofeach honey against these pathogensis primarily due to the high sugar content. METHODS: thirteen pathogens including: four Clostridium difficile, two Methicillin-resistant Staphylococcus aureus, two Pseudomonas aeruginosa, one Methicillin-Susceptible Staphylococcus aureus, twoVancomycin-resistance Enterococcus, one Enterococcusfaecalis and one Klebsiella pneumonia were exposed to 1-50% (w/v) four Wisconsin honeys and Artificial honey to determine their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) using the broth dilution method. RESULTS: buckwheathoney predominantly exhibited a bactericidal mode of action against the tested pathogens, and this varied with each pathogen. C. difficile isolates were more sensitive to the Wisconsin buckwheat honeyas compared to the other pathogens. Artificial honey at 50% (w/v) failed to kill any of the pathogens. The high sugar content of Wisconsin buckwheat honey is not the only factor responsible for its bactericidal activity. CONCLUSION: Wisconsin buckwheat honeyhas the potential to be an important addition to therapeutic armamentarium against resistant pathogens and should be investigated further. https://www.panafrican-med-journal.com/content/article/25/212/pdf/212.pdf buckwheat honeysusceptibilityantibiotic-resistantnosocomial pathogen |
| spellingShingle | Eric Nee-Armah Hammond Megan Duster Jackson Ssentalo Musuuza Nasia Safdar Effect of United States buckwheat honey on antibiotic-resistant hospital acquired pathogens The Pan African Medical Journal buckwheat honey susceptibility antibiotic-resistant nosocomial pathogen |
| title | Effect of United States buckwheat honey on antibiotic-resistant hospital acquired pathogens |
| title_full | Effect of United States buckwheat honey on antibiotic-resistant hospital acquired pathogens |
| title_fullStr | Effect of United States buckwheat honey on antibiotic-resistant hospital acquired pathogens |
| title_full_unstemmed | Effect of United States buckwheat honey on antibiotic-resistant hospital acquired pathogens |
| title_short | Effect of United States buckwheat honey on antibiotic-resistant hospital acquired pathogens |
| title_sort | effect of united states buckwheat honey on antibiotic resistant hospital acquired pathogens |
| topic | buckwheat honey susceptibility antibiotic-resistant nosocomial pathogen |
| url |
https://www.panafrican-med-journal.com/content/article/25/212/pdf/212.pdf
|
| work_keys_str_mv | AT ericneearmahhammond effectofunitedstatesbuckwheathoneyonantibioticresistanthospitalacquiredpathogens AT meganduster effectofunitedstatesbuckwheathoneyonantibioticresistanthospitalacquiredpathogens AT jacksonssentalomusuuza effectofunitedstatesbuckwheathoneyonantibioticresistanthospitalacquiredpathogens AT nasiasafdar effectofunitedstatesbuckwheathoneyonantibioticresistanthospitalacquiredpathogens |