Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis
Background: this study aimed to evaluate the prognostic factors associated with long-term survival after linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for brain metastasis (BM). Methods: This singl...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/9/477 |
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| author | Ryosuke Matsuda Masatoshi Hasegawa Tetsuro Tamamoto Nobuyoshi Inooka Mei Nikimoto Tomoko Ochi Toshiteru Miyasaka Shigeto Hontsu Kaori Yamaki Sachiko Miura Takayuki Morimoto Takaaki Mitsui Takanori Furuta Shohei Yokoyama Masashi Kotsugi Shuichi Yamada Ichiro Nakagawa Young-Soo Park Hiroyuki Nakase |
| author_facet | Ryosuke Matsuda Masatoshi Hasegawa Tetsuro Tamamoto Nobuyoshi Inooka Mei Nikimoto Tomoko Ochi Toshiteru Miyasaka Shigeto Hontsu Kaori Yamaki Sachiko Miura Takayuki Morimoto Takaaki Mitsui Takanori Furuta Shohei Yokoyama Masashi Kotsugi Shuichi Yamada Ichiro Nakagawa Young-Soo Park Hiroyuki Nakase |
| author_sort | Ryosuke Matsuda |
| collection | DOAJ |
| description | Background: this study aimed to evaluate the prognostic factors associated with long-term survival after linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for brain metastasis (BM). Methods: This single-center retrospective study included 226 consecutive patients with BM who were treated with linac-based SRS or fSRT with a micro-multileaf collimator between January 2011 and December 2018. Long-term survival (LTS) was defined as survival for more than 2 years after SRS/fSRT. Results: The tumors originated from the lung (<i>n</i> = 189, 83.6%), breast (<i>n</i> = 11, 4.9%), colon (<i>n</i> = 9, 4.0%), stomach (<i>n</i> = 4, 1.8%), kidney (<i>n</i> = 3, 1.3%), esophagus (<i>n</i> = 3, 1.3%), and other regions (<i>n</i> = 7, 3.1%). The median pretreatment Karnofsky performance scale (KPS) score was 90 (range: 40–100). The median follow-up time was 13 (range: 0–120) months. Out of the 226 patients, 72 (31.8%) were categorized in the LTS group. The median survival time was 43 months and 13 months in the LTS group and in the entire cohort, respectively. The 3-year, 4-year, and 5-year survival rate in the LTS group was 59.1%, 49.6%, and 40.7%, respectively. Multivariate regression logistic analysis showed that female sex, a pre-treatment KPS score ≥ 80, and the absence of extracranial metastasis were associated with long-term survival. Conclusions: female sex, a favorable pre-treatment KPS score, and the absence of extracranial metastasis were associated with long-term survival in the current cohort of patients with BM. |
| first_indexed | 2024-03-10T00:19:30Z |
| format | Article |
| id | doaj.art-0b127ed814d847d9aaada695ccb0111d |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T00:19:30Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-0b127ed814d847d9aaada695ccb0111d2023-11-23T15:45:26ZengMDPI AGCurrent Oncology1198-00521718-77292022-08-012996068607610.3390/curroncol29090477Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain MetastasisRyosuke Matsuda0Masatoshi Hasegawa1Tetsuro Tamamoto2Nobuyoshi Inooka3Mei Nikimoto4Tomoko Ochi5Toshiteru Miyasaka6Shigeto Hontsu7Kaori Yamaki8Sachiko Miura9Takayuki Morimoto10Takaaki Mitsui11Takanori Furuta12Shohei Yokoyama13Masashi Kotsugi14Shuichi Yamada15Ichiro Nakagawa16Young-Soo Park17Hiroyuki Nakase18Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Radiation Oncology, Nara Medical University, Kashihara 634-8521, JapanDepartment of Radiation Oncology, Nara Medical University, Kashihara 634-8521, JapanDepartment of Radiation Oncology, Nara Medical University, Kashihara 634-8521, JapanDepartment of Radiation Oncology, Nara Medical University, Kashihara 634-8521, JapanDepartment of Radiology, Nara Medical University Hospital, Kashihara 634-8522, JapanDepartment of Radiology, Nara Medical University Hospital, Kashihara 634-8522, JapanDepartment of Respiratory Medicine, Nara Medical University Hospital, Kashihara 634-8522, JapanDepartment of Radiation Oncology, Nara Medical University, Kashihara 634-8521, JapanDepartment of Radiation Oncology, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanDepartment of Neurosurgery, Nara Medical University, Kashihara 634-8521, JapanBackground: this study aimed to evaluate the prognostic factors associated with long-term survival after linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for brain metastasis (BM). Methods: This single-center retrospective study included 226 consecutive patients with BM who were treated with linac-based SRS or fSRT with a micro-multileaf collimator between January 2011 and December 2018. Long-term survival (LTS) was defined as survival for more than 2 years after SRS/fSRT. Results: The tumors originated from the lung (<i>n</i> = 189, 83.6%), breast (<i>n</i> = 11, 4.9%), colon (<i>n</i> = 9, 4.0%), stomach (<i>n</i> = 4, 1.8%), kidney (<i>n</i> = 3, 1.3%), esophagus (<i>n</i> = 3, 1.3%), and other regions (<i>n</i> = 7, 3.1%). The median pretreatment Karnofsky performance scale (KPS) score was 90 (range: 40–100). The median follow-up time was 13 (range: 0–120) months. Out of the 226 patients, 72 (31.8%) were categorized in the LTS group. The median survival time was 43 months and 13 months in the LTS group and in the entire cohort, respectively. The 3-year, 4-year, and 5-year survival rate in the LTS group was 59.1%, 49.6%, and 40.7%, respectively. Multivariate regression logistic analysis showed that female sex, a pre-treatment KPS score ≥ 80, and the absence of extracranial metastasis were associated with long-term survival. Conclusions: female sex, a favorable pre-treatment KPS score, and the absence of extracranial metastasis were associated with long-term survival in the current cohort of patients with BM.https://www.mdpi.com/1718-7729/29/9/477linac with a micro-multileaf collimatorbrain metastasislong-term survivorsstereotactic radiosurgerystereotactic radiotherapy |
| spellingShingle | Ryosuke Matsuda Masatoshi Hasegawa Tetsuro Tamamoto Nobuyoshi Inooka Mei Nikimoto Tomoko Ochi Toshiteru Miyasaka Shigeto Hontsu Kaori Yamaki Sachiko Miura Takayuki Morimoto Takaaki Mitsui Takanori Furuta Shohei Yokoyama Masashi Kotsugi Shuichi Yamada Ichiro Nakagawa Young-Soo Park Hiroyuki Nakase Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis Current Oncology linac with a micro-multileaf collimator brain metastasis long-term survivors stereotactic radiosurgery stereotactic radiotherapy |
| title | Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis |
| title_full | Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis |
| title_fullStr | Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis |
| title_full_unstemmed | Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis |
| title_short | Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis |
| title_sort | long term survival after linac based stereotactic radiosurgery and radiotherapy with a micro multileaf collimator for brain metastasis |
| topic | linac with a micro-multileaf collimator brain metastasis long-term survivors stereotactic radiosurgery stereotactic radiotherapy |
| url | https://www.mdpi.com/1718-7729/29/9/477 |
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