The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization
Background. It has been shown that the available therapeutic agents do not eliminate the consequences of miotic pathologies in chronic alcoholism, the most significant of which are disturbances in the dynamics of muscle contraction. A positive effect of biocompatible water-soluble C60 fullerenes on...
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| Language: | English |
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Львівський національний університет імені Івана Франка
2024-03-01
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| Series: | Біологічні студії |
| Subjects: | |
| Online Access: | http://publications.lnu.edu.ua/journals/index.php/biology/article/view/3883 |
| _version_ | 1797265226960207872 |
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| author | Dmytro Nozdrenko Wang Nan Oleksandr Motuziuk Svitlana Prylutska Oksana Vygovska Kateryna Bogutska Оlena Dmytrotsa Oksana Lynchak Yuriy Prylutskyy |
| author_facet | Dmytro Nozdrenko Wang Nan Oleksandr Motuziuk Svitlana Prylutska Oksana Vygovska Kateryna Bogutska Оlena Dmytrotsa Oksana Lynchak Yuriy Prylutskyy |
| author_sort | Dmytro Nozdrenko |
| collection | DOAJ |
| description | Background. It has been shown that the available therapeutic agents do not eliminate the consequences of miotic pathologies in chronic alcoholism, the most significant of which are disturbances in the dynamics of muscle contraction. A positive effect of biocompatible water-soluble C60 fullerenes on the contraction parameters of damaged muscles has been established. In addition, administration of C60 fullerene aqueous solution during chronic alcoholization of rats protects muscle tissue from damage caused by oxidative stress.
Materials and Methods. Biomechanical parameters such as the values of the minimum and maximum contraction force and the muscle force impulse were evaluated using tensometry. The blood levels of creatine phosphokinase and lactate dehydrogenase, creatinine and lactate as well as the level of oxidative processes in muscle tissue of experimental animals (content of hydrogen peroxide, activity of catalase, glutathione peroxidase and superoxide dismutase) as markers of muscle damage were determined using methods of biochemical analysis.
Results. The C60 fullerene aqueous solution effect on the skeletal muscle contraction dynamics in rats after chronic alcoholization for 9 months and cessation of alcohol consumption for 1 month was investigated. It was established that water-soluble C60 fullerenes (daily dose of 1 mg/kg) reduce the effects of chronic alcoholization by 35–40±2 % on the studied biomechanical parameters and by 20±1 % on the studied biochemical parameters compared to the group of alcoholized animals, thus increasing the energy capabilities of the muscular system.
Conclusions. The obtained data indicate a pronounced protective effect of C60 fullerenes on the muscle soleus contraction dynamics during the development of alcoholic myopathy, which opens up the potential possibility of their use for the prevention and correction of miotic damage. |
| first_indexed | 2024-04-25T00:41:26Z |
| format | Article |
| id | doaj.art-0b12da14d03e4d85a6906df02336d124 |
| institution | Directory Open Access Journal |
| issn | 1996-4536 2311-0783 |
| language | English |
| last_indexed | 2024-04-25T00:41:26Z |
| publishDate | 2024-03-01 |
| publisher | Львівський національний університет імені Івана Франка |
| record_format | Article |
| series | Біологічні студії |
| spelling | doaj.art-0b12da14d03e4d85a6906df02336d1242024-03-12T09:00:04ZengЛьвівський національний університет імені Івана ФранкаБіологічні студії1996-45362311-07832024-03-01181435610.30970/sbi.1801.755The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholizationDmytro Nozdrenko0https://orcid.org/0000-0001-7254-1533Wang Nan1https://orcid.org/0000-0002-5774-2596Oleksandr Motuziuk2https://orcid.org/0000-0002-1520-0721Svitlana Prylutska3https://orcid.org/0000-0001-5280-8341Oksana Vygovska4https://orcid.org/0000-0003-1978-9817Kateryna Bogutska5https://orcid.org/0000-0003-0202-8042Оlena Dmytrotsa6https://orcid.org/0000-0002-8127-6396Oksana Lynchak7https://orcid.org/0000-0002-1495-3190Yuriy Prylutskyy8https://orcid.org/0000-0002-9847-4137Taras Shevchenko National University of KyivLesya Ukrainka Volyn National UniversityTaras Shevchenko National University of Kyiv; Lesya Ukrainka Volyn National UniversityNational University of Life and Environmental Science of UkraineBogomolets National Medical University of KyivTaras Shevchenko National University of KyivLesya Ukrainka Volyn National UniversityTaras Shevchenko National University of KyivTaras Shevchenko National University of KyivBackground. It has been shown that the available therapeutic agents do not eliminate the consequences of miotic pathologies in chronic alcoholism, the most significant of which are disturbances in the dynamics of muscle contraction. A positive effect of biocompatible water-soluble C60 fullerenes on the contraction parameters of damaged muscles has been established. In addition, administration of C60 fullerene aqueous solution during chronic alcoholization of rats protects muscle tissue from damage caused by oxidative stress. Materials and Methods. Biomechanical parameters such as the values of the minimum and maximum contraction force and the muscle force impulse were evaluated using tensometry. The blood levels of creatine phosphokinase and lactate dehydrogenase, creatinine and lactate as well as the level of oxidative processes in muscle tissue of experimental animals (content of hydrogen peroxide, activity of catalase, glutathione peroxidase and superoxide dismutase) as markers of muscle damage were determined using methods of biochemical analysis. Results. The C60 fullerene aqueous solution effect on the skeletal muscle contraction dynamics in rats after chronic alcoholization for 9 months and cessation of alcohol consumption for 1 month was investigated. It was established that water-soluble C60 fullerenes (daily dose of 1 mg/kg) reduce the effects of chronic alcoholization by 35–40±2 % on the studied biomechanical parameters and by 20±1 % on the studied biochemical parameters compared to the group of alcoholized animals, thus increasing the energy capabilities of the muscular system. Conclusions. The obtained data indicate a pronounced protective effect of C60 fullerenes on the muscle soleus contraction dynamics during the development of alcoholic myopathy, which opens up the potential possibility of their use for the prevention and correction of miotic damage.http://publications.lnu.edu.ua/journals/index.php/biology/article/view/3883muscle soleusalcoholizationc60 fullerenebiomechanical parameters of skeletal muscle contractionbiochemical indicators |
| spellingShingle | Dmytro Nozdrenko Wang Nan Oleksandr Motuziuk Svitlana Prylutska Oksana Vygovska Kateryna Bogutska Оlena Dmytrotsa Oksana Lynchak Yuriy Prylutskyy The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization Біологічні студії muscle soleus alcoholization c60 fullerene biomechanical parameters of skeletal muscle contraction biochemical indicators |
| title | The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization |
| title_full | The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization |
| title_fullStr | The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization |
| title_full_unstemmed | The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization |
| title_short | The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization |
| title_sort | effect of c60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization |
| topic | muscle soleus alcoholization c60 fullerene biomechanical parameters of skeletal muscle contraction biochemical indicators |
| url | http://publications.lnu.edu.ua/journals/index.php/biology/article/view/3883 |
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