MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer

MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer

Globally, bladder cancer (BLCA) is still the leading cause of death in patients with tumors. The function and underlying mechanism of MTX-211, an EFGR and PI3K kinase inhibitor, have not been elucidated. This study examined the function of MTX-211 in BLCA cells using in vitro and in vivo assays. RNA...

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Bibliographic Details
Main Authors: Bing Hu, Ru Chen, Ming Jiang, Situ Xiong, An Xie, Xiaoqiang Liu, Bin Fu
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
MTX-211
GSH metabolism
proliferation
Keap1/NRF2/GCLM
bladder cancer
Online Access:https://www.mdpi.com/1422-0067/24/8/7608

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