The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
Several types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/5/265 |
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| author | Jun-O. Jin Pallavi Singh Chauhan Ananta Prasad Arukha Vishal Chavda Anuj Dubey Dhananjay Yadav |
| author_facet | Jun-O. Jin Pallavi Singh Chauhan Ananta Prasad Arukha Vishal Chavda Anuj Dubey Dhananjay Yadav |
| author_sort | Jun-O. Jin |
| collection | DOAJ |
| description | Several types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained much attention as an antitumor drug owing to its anticancer effects against multiple cancer types. Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages. Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage. The synergistic effect of fucoidan with existing anticancer drugs has prompted researchers to explore its therapeutic potential. This review compiles the mechanisms through which fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs. The obstacles involved in developing fucoidan as an anticancer agent are also discussed in this review. |
| first_indexed | 2024-03-10T11:34:17Z |
| format | Article |
| id | doaj.art-0b14fa2ae9b847d0b5d92dbe7fca0e99 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T11:34:17Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-0b14fa2ae9b847d0b5d92dbe7fca0e992023-11-21T18:57:29ZengMDPI AGMarine Drugs1660-33972021-05-0119526510.3390/md19050265The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and HurdlesJun-O. Jin0Pallavi Singh Chauhan1Ananta Prasad Arukha2Vishal Chavda3Anuj Dubey4Dhananjay Yadav5Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, ChinaAmity Institute of Biotechnology, Amity University Madhya Pradesh, Gwalior 474005, IndiaComparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USADivision of Anaesthesia, Sardar Women’s Hospital, Ahmedabad 380004, Gujarat, IndiaDepartment of Chemistry, ITM Group of Institutions, Gwalior 475005, IndiaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, KoreaSeveral types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained much attention as an antitumor drug owing to its anticancer effects against multiple cancer types. Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages. Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage. The synergistic effect of fucoidan with existing anticancer drugs has prompted researchers to explore its therapeutic potential. This review compiles the mechanisms through which fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs. The obstacles involved in developing fucoidan as an anticancer agent are also discussed in this review.https://www.mdpi.com/1660-3397/19/5/265anticancer activityfucoidantumor growthcytotoxic effectsbrown algae |
| spellingShingle | Jun-O. Jin Pallavi Singh Chauhan Ananta Prasad Arukha Vishal Chavda Anuj Dubey Dhananjay Yadav The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles Marine Drugs anticancer activity fucoidan tumor growth cytotoxic effects brown algae |
| title | The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles |
| title_full | The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles |
| title_fullStr | The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles |
| title_full_unstemmed | The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles |
| title_short | The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles |
| title_sort | therapeutic potential of the anticancer activity of fucoidan current advances and hurdles |
| topic | anticancer activity fucoidan tumor growth cytotoxic effects brown algae |
| url | https://www.mdpi.com/1660-3397/19/5/265 |
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