Determination of unbound piperaquine in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry

Determination of unbound piperaquine in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry

Piperaquine (PQ) is an antimalarial drug that is highly protein-bound. Variation in plasma protein contents may affect the pharmacokinetic (PK) exposure of unbound drug, leading to alteration of clinical outcomes. All published methods for determination of PQ in human plasma measure the total PQ inc...

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Bibliographic Details
Main Authors:	Liusheng Huang, Vong Sok, Usman Aslam-Mir, Florence Marzan, Meghan Whalen, Philip J. Rosenthal, Francesca Aweeka
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Series:	Journal of Chromatography Open
Subjects:	Piperaquine UHPLC-MS/MS Plasma filtrate Plasma Unbound free
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772391722000135

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