Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

Adjuvant tamoxifen therapy improves survival in breast cancer patients. Unfortunately, long-term treatment comes with side effects that impact health and quality of life, including hot flashes, changes in bone density, and fatigue. Partly due to a lack of proven animal models, the tissues and cells...

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Bibliographic Details
Main Authors: Zhi Zhang, Jae Whan Park, In Sook Ahn, Graciel Diamante, Nilla Sivakumar, Douglas Arneson, Xia Yang, J Edward van Veen, Stephanie M Correa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
tamoxifen
hypothalamus
estrogen receptor alpha
thermoregulation
physical activity
bone
Online Access:https://elifesciences.org/articles/63333

Internet

https://elifesciences.org/articles/63333

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