The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial
<p><strong>Introduction:</strong> Renal colic can be managed by preventing the contraction movements of ureter muscles. By reducing acetylcholine in the nerve terminals, magnesium sulfate could be effective in this regard. The aim of this study is to investigate the effect of magne...
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2016-12-01
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| Series: | Emergency |
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| Online Access: | http://journals.sbmu.ac.ir/emergency/article/view/13025 |
| _version_ | 1818477144581341184 |
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| author | Abolfazl Jokar Ali Cyrus Maryam Babaei Majid Taheri Amir Almasi-Hashiani Ezatollah Behzadinia Arash Yazdanbakhsh |
| author_facet | Abolfazl Jokar Ali Cyrus Maryam Babaei Majid Taheri Amir Almasi-Hashiani Ezatollah Behzadinia Arash Yazdanbakhsh |
| author_sort | Abolfazl Jokar |
| collection | DOAJ |
| description | <p><strong>Introduction:</strong> Renal colic can be managed by preventing the contraction movements of ureter muscles. By reducing acetylcholine in the nerve terminals, magnesium sulfate could be effective in this regard. The aim of this study is to investigate the effect of magnesium sulfate on acute renal colic pain relief. <strong>Method: </strong>The present study was a double-blind clinical trial in which the patients suffering from acute renal colic were randomly divided into 2 groups of who either received standard protocol (intravenous infusion of 0.1 mg/Kg morphine sulfate, 30 mg of Ketorolac, and 100 ml normal saline as placebo/15 minutes) or standard protocol plus 15 mg/Kg of intravenous magnesium sulfate 50%/100 ml normal saline/15 minutes. Severity of patients’ pain was measured by visual analogue scale (VAS) at baseline, and 30 and 60 minutes after infusion. The collected data were analyzed using STATA statistical software. <strong>Results:</strong> 100 cases were randomly allocated to intervention or control group. The two groups were similar in baseline pain score and demographic characteristics. At 30 and 60 minutes, mean pain score was less in the intervention group compared to the control group. Moreover, the difference between the two groups was statistically significant regarding the additional amount of morphine, suggesting that the intervention group needed less additional morphine than the control group. <strong>Conclusion:</strong> The results of this study showed that Magnesium sulfate can be used as an adjunct drug in treatment of patients suffering from renal colic. It not only alleviates the pain in the patients, but also diminishes the need for pain medications.</p> |
| first_indexed | 2024-12-10T09:34:25Z |
| format | Article |
| id | doaj.art-0b15d03d616f4572b4b1ec7dee4210f4 |
| institution | Directory Open Access Journal |
| issn | 2345-4563 2345-4571 |
| language | English |
| last_indexed | 2024-12-10T09:34:25Z |
| publishDate | 2016-12-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Emergency |
| spelling | doaj.art-0b15d03d616f4572b4b1ec7dee4210f42022-12-22T01:54:13ZengShahid Beheshti University of Medical SciencesEmergency2345-45632345-45712016-12-0151e25e2510.22037/emergency.v5i1.130257660The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical TrialAbolfazl Jokar0Ali Cyrus1Maryam Babaei2Majid Taheri3Amir Almasi-Hashiani4Ezatollah Behzadinia5Arash Yazdanbakhsh6Department of Emergency Medicine, Arak University of Medical Sciences, Arak, Iran.Department of Emergency Medicine, Arak University of Medical Sciences, Arak, Iran.Department of Emergency Medicine, Arak University of Medical Sciences, Arak, Iran.Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.Department of Emergency Medicine, Arak University of Medical Sciences, Arak, Iran.Department of Emergency Medicine, Arak University of Medical Sciences, Arak, Iran.<p><strong>Introduction:</strong> Renal colic can be managed by preventing the contraction movements of ureter muscles. By reducing acetylcholine in the nerve terminals, magnesium sulfate could be effective in this regard. The aim of this study is to investigate the effect of magnesium sulfate on acute renal colic pain relief. <strong>Method: </strong>The present study was a double-blind clinical trial in which the patients suffering from acute renal colic were randomly divided into 2 groups of who either received standard protocol (intravenous infusion of 0.1 mg/Kg morphine sulfate, 30 mg of Ketorolac, and 100 ml normal saline as placebo/15 minutes) or standard protocol plus 15 mg/Kg of intravenous magnesium sulfate 50%/100 ml normal saline/15 minutes. Severity of patients’ pain was measured by visual analogue scale (VAS) at baseline, and 30 and 60 minutes after infusion. The collected data were analyzed using STATA statistical software. <strong>Results:</strong> 100 cases were randomly allocated to intervention or control group. The two groups were similar in baseline pain score and demographic characteristics. At 30 and 60 minutes, mean pain score was less in the intervention group compared to the control group. Moreover, the difference between the two groups was statistically significant regarding the additional amount of morphine, suggesting that the intervention group needed less additional morphine than the control group. <strong>Conclusion:</strong> The results of this study showed that Magnesium sulfate can be used as an adjunct drug in treatment of patients suffering from renal colic. It not only alleviates the pain in the patients, but also diminishes the need for pain medications.</p>http://journals.sbmu.ac.ir/emergency/article/view/13025Renal colicmagnesium sulfatetherapeutics |
| spellingShingle | Abolfazl Jokar Ali Cyrus Maryam Babaei Majid Taheri Amir Almasi-Hashiani Ezatollah Behzadinia Arash Yazdanbakhsh The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial Emergency Renal colic magnesium sulfate therapeutics |
| title | The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial |
| title_full | The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial |
| title_fullStr | The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial |
| title_full_unstemmed | The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial |
| title_short | The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial |
| title_sort | effect of magnesium sulfate on renal colic pain relief a randomized clinical trial |
| topic | Renal colic magnesium sulfate therapeutics |
| url | http://journals.sbmu.ac.ir/emergency/article/view/13025 |
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