The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis
Stearoyl-coenzyme A desaturase 1 (SCD1) is a microsomal enzyme that controls fatty acid metabolism and is highly expressed in hepatocytes. SCD1 may play a key role in liver development and hepatic lipid homeostasis through promoting monounsaturated protein acylation and converting lipotoxic saturate...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Codon Publications
2019-02-01
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| Series: | Journal of Renal and Hepatic Disorders |
| Subjects: | |
| Online Access: | https://jrenhep.com/index.php/jrenhep/article/view/49 |
| _version_ | 1811304272564846592 |
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| author | Fatemeh Mohammadzadeh Vahid Hosseini Alireza Alihemmati Amir Mehdizadeh Maghsod Shaaker Gholamali Mosayyebi Masoud Darabi |
| author_facet | Fatemeh Mohammadzadeh Vahid Hosseini Alireza Alihemmati Amir Mehdizadeh Maghsod Shaaker Gholamali Mosayyebi Masoud Darabi |
| author_sort | Fatemeh Mohammadzadeh |
| collection | DOAJ |
| description | Stearoyl-coenzyme A desaturase 1 (SCD1) is a microsomal enzyme that controls fatty acid metabolism and is highly expressed in hepatocytes. SCD1 may play a key role in liver development and hepatic lipid homeostasis through promoting monounsaturated protein acylation and converting lipotoxic saturated fatty acids into monounsaturated fatty acids. Imbalanced activity of SCD1 has been implicated in fatty liver induction, inflammation and stress. In this review, the role of SCD1 in hepatic development, function and pathogenesis is discussed. Additionally, emerging novel therapeutic agents targeting SCD1 for the treatment of liver disorders are presented. |
| first_indexed | 2024-04-13T08:04:19Z |
| format | Article |
| id | doaj.art-0b15f07e8a3141608f8272de00466d60 |
| institution | Directory Open Access Journal |
| issn | 2207-3744 |
| language | English |
| last_indexed | 2024-04-13T08:04:19Z |
| publishDate | 2019-02-01 |
| publisher | Codon Publications |
| record_format | Article |
| series | Journal of Renal and Hepatic Disorders |
| spelling | doaj.art-0b15f07e8a3141608f8272de00466d602022-12-22T02:55:13ZengCodon PublicationsJournal of Renal and Hepatic Disorders2207-37442019-02-013110.15586/jrenhep.2019.49The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and PathogenesisFatemeh Mohammadzadeh0Vahid Hosseini1Alireza Alihemmati2Amir Mehdizadeh3Maghsod Shaaker4Gholamali Mosayyebi5Masoud Darabi6Emergency Medicine Research Center Team, Department of Emergency Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.Emergency Medicine Research Center Team, Department of Emergency Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.Emergency Medicine Research Center Team, Department of Emergency Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.Liver and Gastrointestinal Research Center, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.Emergency Medicine Research Center Team, Department of Emergency Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.Stearoyl-coenzyme A desaturase 1 (SCD1) is a microsomal enzyme that controls fatty acid metabolism and is highly expressed in hepatocytes. SCD1 may play a key role in liver development and hepatic lipid homeostasis through promoting monounsaturated protein acylation and converting lipotoxic saturated fatty acids into monounsaturated fatty acids. Imbalanced activity of SCD1 has been implicated in fatty liver induction, inflammation and stress. In this review, the role of SCD1 in hepatic development, function and pathogenesis is discussed. Additionally, emerging novel therapeutic agents targeting SCD1 for the treatment of liver disorders are presented.https://jrenhep.com/index.php/jrenhep/article/view/49hepatic lipogenesishydroxy pyridineMK-8245stearoyl-coenzyme A desaturase 1SCD1 |
| spellingShingle | Fatemeh Mohammadzadeh Vahid Hosseini Alireza Alihemmati Amir Mehdizadeh Maghsod Shaaker Gholamali Mosayyebi Masoud Darabi The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis Journal of Renal and Hepatic Disorders hepatic lipogenesis hydroxy pyridine MK-8245 stearoyl-coenzyme A desaturase 1 SCD1 |
| title | The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis |
| title_full | The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis |
| title_fullStr | The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis |
| title_full_unstemmed | The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis |
| title_short | The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis |
| title_sort | role of stearoyl coenzyme a desaturase 1 in liver development function and pathogenesis |
| topic | hepatic lipogenesis hydroxy pyridine MK-8245 stearoyl-coenzyme A desaturase 1 SCD1 |
| url | https://jrenhep.com/index.php/jrenhep/article/view/49 |
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