Fresh insights into the pyrimidine metabolism in the trypanosomatids
Abstract The trypanosomatid parasites continue their killing spree resulting in significant annual mortality due to the lack of effective treatments and the prominence of these diseases in poorer countries. These dimorphic parasites thrive unchecked in the host system, outsmarting the immune mechani...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13071-018-2660-8 |
| _version_ | 1818916599690690560 |
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| author | Kartikeya Tiwari Vikash Kumar Dubey |
| author_facet | Kartikeya Tiwari Vikash Kumar Dubey |
| author_sort | Kartikeya Tiwari |
| collection | DOAJ |
| description | Abstract The trypanosomatid parasites continue their killing spree resulting in significant annual mortality due to the lack of effective treatments and the prominence of these diseases in poorer countries. These dimorphic parasites thrive unchecked in the host system, outsmarting the immune mechanisms. An understanding of biology of these parasitic forms will help in the management and elimination of these fatal diseases. Investigation of various metabolic pathways in these parasites has shed light in the understanding of the unique biology of the trypansomatids. An understanding of these pathways have helped in tracing the soft targets in the metabolic pathways, which could be used as effective drug targets which would further impact the therupeutic implications. Pyrimidine pathway is a vital metabolic pathway which yields in the formation of pyrimidines, which are then integrated in nucleic acids (DNA and RNA) in sugars (UDP sugars) and lipids (CDP lipids). A wealth of data and information has been generated in the past decades by in-depth analyses of pyrimidine pathway in the trypanosomatid parasites, which can aid in the identification of anomalies between the parasitic and host counterpart which could be further harnessed to develop therapeutic interventions for the treatment of parasitic diseases. This review presents an updated and comprehensive detailing of the pyrimidine metabolism in the trypansomatids, their uniqueness and their distinctions, and its possible outcomes that would aid in the eradication of these parasitic diseases. |
| first_indexed | 2024-12-20T00:20:44Z |
| format | Article |
| id | doaj.art-0b1703a0f7e44f18a8ce83e186d6266a |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-20T00:20:44Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-0b1703a0f7e44f18a8ce83e186d6266a2022-12-21T20:00:12ZengBMCParasites & Vectors1756-33052018-02-0111111510.1186/s13071-018-2660-8Fresh insights into the pyrimidine metabolism in the trypanosomatidsKartikeya Tiwari0Vikash Kumar Dubey1Department of Biosciences and Bioengineering, Indian Institute of Technology GuwahatiDepartment of Biosciences and Bioengineering, Indian Institute of Technology GuwahatiAbstract The trypanosomatid parasites continue their killing spree resulting in significant annual mortality due to the lack of effective treatments and the prominence of these diseases in poorer countries. These dimorphic parasites thrive unchecked in the host system, outsmarting the immune mechanisms. An understanding of biology of these parasitic forms will help in the management and elimination of these fatal diseases. Investigation of various metabolic pathways in these parasites has shed light in the understanding of the unique biology of the trypansomatids. An understanding of these pathways have helped in tracing the soft targets in the metabolic pathways, which could be used as effective drug targets which would further impact the therupeutic implications. Pyrimidine pathway is a vital metabolic pathway which yields in the formation of pyrimidines, which are then integrated in nucleic acids (DNA and RNA) in sugars (UDP sugars) and lipids (CDP lipids). A wealth of data and information has been generated in the past decades by in-depth analyses of pyrimidine pathway in the trypanosomatid parasites, which can aid in the identification of anomalies between the parasitic and host counterpart which could be further harnessed to develop therapeutic interventions for the treatment of parasitic diseases. This review presents an updated and comprehensive detailing of the pyrimidine metabolism in the trypansomatids, their uniqueness and their distinctions, and its possible outcomes that would aid in the eradication of these parasitic diseases.http://link.springer.com/article/10.1186/s13071-018-2660-8TrypanosomatidsTrypanosomaLeishmaniaCrithidiaPyrimidine |
| spellingShingle | Kartikeya Tiwari Vikash Kumar Dubey Fresh insights into the pyrimidine metabolism in the trypanosomatids Parasites & Vectors Trypanosomatids Trypanosoma Leishmania Crithidia Pyrimidine |
| title | Fresh insights into the pyrimidine metabolism in the trypanosomatids |
| title_full | Fresh insights into the pyrimidine metabolism in the trypanosomatids |
| title_fullStr | Fresh insights into the pyrimidine metabolism in the trypanosomatids |
| title_full_unstemmed | Fresh insights into the pyrimidine metabolism in the trypanosomatids |
| title_short | Fresh insights into the pyrimidine metabolism in the trypanosomatids |
| title_sort | fresh insights into the pyrimidine metabolism in the trypanosomatids |
| topic | Trypanosomatids Trypanosoma Leishmania Crithidia Pyrimidine |
| url | http://link.springer.com/article/10.1186/s13071-018-2660-8 |
| work_keys_str_mv | AT kartikeyatiwari freshinsightsintothepyrimidinemetabolisminthetrypanosomatids AT vikashkumardubey freshinsightsintothepyrimidinemetabolisminthetrypanosomatids |