Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) Registry
Background: Previous cohort studies focused on relative risk stratification among patients diagnosed with vasospastic angina, and it is unknown how much vasospasm accounts for the cause of out-of-hospital cardiac arrest, and whether prognosis differs. Methods: From a registry data collected from 6...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2022-06-01
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| Series: | Anatolian Journal of Cardiology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-48757 |
| _version_ | 1797634112814579712 |
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| author | Hyo Eun Park Sang Hoon Na Sang Do Shin Jin Wi Sang-Hyun Kim Jinho Choi Jong-Il Choi Youngjin Cho Myung-Jin Cha Kyung-Hee Kim |
| author_facet | Hyo Eun Park Sang Hoon Na Sang Do Shin Jin Wi Sang-Hyun Kim Jinho Choi Jong-Il Choi Youngjin Cho Myung-Jin Cha Kyung-Hee Kim |
| author_sort | Hyo Eun Park |
| collection | DOAJ |
| description | Background: Previous cohort studies focused on relative risk stratification among patients diagnosed with vasospastic angina, and it is unknown how much vasospasm accounts for the cause of out-of-hospital cardiac arrest, and whether prognosis differs.
Methods: From a registry data collected from 65 hospitals in Korea, 863 subjects who survived hospital cardiac arrest were evaluated. The patients with insignificant coro-nary lesion, vasospasm, and obstructive lesion were each grouped as group I, group II, and group III, respectively. The primary and secondary outcomes were survival to hospital discharge and good neurological function at discharge defined as cerebral performance index 1.
Results: At hospital discharge, 529 subjects (61.3%) survived. There was no significant difference in survival according to coronary angiographic findings (P =.133 and P =.357, group II and group III compared to group I), but the neurological outcome was significantly better in groups II and III (P =.046 and P =.022, groups II and III compared to group I). Two multivariate models were evaluated to adjust traditional risk factors and cardiac biomarkers. The presence of coronary artery vasospasm did not affect survival to hospital discharge (P = 0.060 and P =.162 for both models), but neurological function was significantly better (OR: 1.965, 95% CI: 1.048-3.684, P =.035, and OR: 1.706, 95% CI: 1.012-2.878, P =.045 for vasospasm, models I and II, respectively).
Conclusions: Coronary vasospasm does not show better survival to hospital discharge, but shows better neurological outcomes. Aggressive coronary angiography and intensive medical treatment for adequate control of vasospasm should be emphasized to prevent and manage fatal events. |
| first_indexed | 2024-03-11T12:03:17Z |
| format | Article |
| id | doaj.art-0b1770b4d60b4a89a0f5537150548d31 |
| institution | Directory Open Access Journal |
| issn | 2149-2271 |
| language | English |
| last_indexed | 2024-03-11T12:03:17Z |
| publishDate | 2022-06-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Anatolian Journal of Cardiology |
| spelling | doaj.art-0b1770b4d60b4a89a0f5537150548d312023-11-07T17:48:40ZengKARE PublishingAnatolian Journal of Cardiology2149-22712022-06-0126645045910.5152/AnatolJCardiol.2022.604AJC-48757Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) RegistryHyo Eun Park0Sang Hoon Na1Sang Do Shin2Jin Wi3Sang-Hyun Kim4Jinho Choi5Jong-Il Choi6Youngjin Cho7Myung-Jin Cha8Kyung-Hee Kim9Department of Internal Medicine, Division of Cardiology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, KoreaDepartment of Internal Medicine, Division of Cardiology, Seoul National University Hospital, Seoul, KoreaDepartment of Emergency Medicine, Seoul National University Hospital, Seoul, KoreaDepartment of Internal Medicine, Division of Cardiology, Gachon University Gil Medical Center, Seoul, KoreaDepartment of Internal Medicine, Division of Cardiology, Seoul National University Boramae Medical Center, Seoul, KoreaDepartment of Internal Medicine, Division of Cardiology, Samsung Medical Center, Seoul, KoreDepartment of Internal Medicine, Division of Cardiology, Korea University Anam Hospital, Seoul, KoreaDepartment of Internal Medicine, Division of Cardiology, Seoul National University Bundang Hospital, Seoul, KoreaDepartment of Internal Medicine, Division of Cardiology, Seoul National University Hospital, Seoul, KoreaDepartment of Internal Medicine, Division of Cardiology, Sejong General Hospital, Seoul, KoreaBackground: Previous cohort studies focused on relative risk stratification among patients diagnosed with vasospastic angina, and it is unknown how much vasospasm accounts for the cause of out-of-hospital cardiac arrest, and whether prognosis differs. Methods: From a registry data collected from 65 hospitals in Korea, 863 subjects who survived hospital cardiac arrest were evaluated. The patients with insignificant coro-nary lesion, vasospasm, and obstructive lesion were each grouped as group I, group II, and group III, respectively. The primary and secondary outcomes were survival to hospital discharge and good neurological function at discharge defined as cerebral performance index 1. Results: At hospital discharge, 529 subjects (61.3%) survived. There was no significant difference in survival according to coronary angiographic findings (P =.133 and P =.357, group II and group III compared to group I), but the neurological outcome was significantly better in groups II and III (P =.046 and P =.022, groups II and III compared to group I). Two multivariate models were evaluated to adjust traditional risk factors and cardiac biomarkers. The presence of coronary artery vasospasm did not affect survival to hospital discharge (P = 0.060 and P =.162 for both models), but neurological function was significantly better (OR: 1.965, 95% CI: 1.048-3.684, P =.035, and OR: 1.706, 95% CI: 1.012-2.878, P =.045 for vasospasm, models I and II, respectively). Conclusions: Coronary vasospasm does not show better survival to hospital discharge, but shows better neurological outcomes. Aggressive coronary angiography and intensive medical treatment for adequate control of vasospasm should be emphasized to prevent and manage fatal events.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-48757kocarc; cardiac arrest; vasospasm; outcome |
| spellingShingle | Hyo Eun Park Sang Hoon Na Sang Do Shin Jin Wi Sang-Hyun Kim Jinho Choi Jong-Il Choi Youngjin Cho Myung-Jin Cha Kyung-Hee Kim Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) Registry Anatolian Journal of Cardiology kocarc; cardiac arrest; vasospasm; outcome |
| title | Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) Registry |
| title_full | Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) Registry |
| title_fullStr | Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) Registry |
| title_full_unstemmed | Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) Registry |
| title_short | Does Coronary Vasospasm Show a Better Prognosis in Out of Hospital Cardiac Arrest: Data from the Korean Cardiac Arrest Research Consortium (KoCARC) Registry |
| title_sort | does coronary vasospasm show a better prognosis in out of hospital cardiac arrest data from the korean cardiac arrest research consortium kocarc registry |
| topic | kocarc; cardiac arrest; vasospasm; outcome |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-48757 |
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