Effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum BDNF: a randomized controlled trial
BackgroundIntracerebral hemorrhage (ICH) is a common cerebrovascular disease, with a high rate of disability. In the literature on Chinese traditional medicine, there is increasing evidence that acupuncture can help hematoma absorption and improve neurological deficits after cerebral hemorrhage. Bra...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1167620/full |
| _version_ | 1797847605247475712 |
|---|---|
| author | Lingcong Li Xiujing Wang Jiaxun Guo Yilin Chen Zhenyu Wang |
| author_facet | Lingcong Li Xiujing Wang Jiaxun Guo Yilin Chen Zhenyu Wang |
| author_sort | Lingcong Li |
| collection | DOAJ |
| description | BackgroundIntracerebral hemorrhage (ICH) is a common cerebrovascular disease, with a high rate of disability. In the literature on Chinese traditional medicine, there is increasing evidence that acupuncture can help hematoma absorption and improve neurological deficits after cerebral hemorrhage. Brain-derived neurotrophic factor (BDNF), one of the most studied neurotrophic factors, is involved in a variety of neurological functions and plays an important role in brain injury recovery. We investigated the effect of acupuncture intervention in the acute phase of ICH on the prognosis and serum BDNF levels of several patient groups.ObjectiveTo investigate the influence of acupuncture on the prognosis and brain-derived neurotrophic factor (BDNF) levels in patients in the acute phase of ICH.MethodsFrom November 2021 to May 2022, 109 subjects were consecutively enrolled, including patients with ICH, who were randomized into the acupuncture group (AG) and sham acupuncture group (SAG), and a control group (CG). The CG received the same acupuncture intervention as the AG, and the SAG received sham acupuncture, with 14 interventions in each group. The level of consciousness of patients with ICH was assessed and serum BDNF levels were measured in all three groups before the intervention and at 3 weeks after onset, and the level of consciousness and outcomes were assessed at 12 weeks after onset.ResultsAfter the intervention, the level of consciousness of the AG improved significantly (P < 0.05); the BDNF level of only the AG increased significantly (P < 0.05); the changes in Glasgow Coma Scale (GCS) score and BDNF level were significantly greater in the AG than in the SAG (P < 0.05), especially for locomotion (P < 0.05). At 12 weeks post-onset, the AG showed better outcomes and recovery of consciousness than the SAG (P < 0.05). |
| first_indexed | 2024-04-09T18:15:14Z |
| format | Article |
| id | doaj.art-0b1961c5071f48be95f19171fc6f77e4 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T18:15:14Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0b1961c5071f48be95f19171fc6f77e42023-04-13T04:41:23ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-04-011710.3389/fnins.2023.11676201167620Effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum BDNF: a randomized controlled trialLingcong LiXiujing WangJiaxun GuoYilin ChenZhenyu WangBackgroundIntracerebral hemorrhage (ICH) is a common cerebrovascular disease, with a high rate of disability. In the literature on Chinese traditional medicine, there is increasing evidence that acupuncture can help hematoma absorption and improve neurological deficits after cerebral hemorrhage. Brain-derived neurotrophic factor (BDNF), one of the most studied neurotrophic factors, is involved in a variety of neurological functions and plays an important role in brain injury recovery. We investigated the effect of acupuncture intervention in the acute phase of ICH on the prognosis and serum BDNF levels of several patient groups.ObjectiveTo investigate the influence of acupuncture on the prognosis and brain-derived neurotrophic factor (BDNF) levels in patients in the acute phase of ICH.MethodsFrom November 2021 to May 2022, 109 subjects were consecutively enrolled, including patients with ICH, who were randomized into the acupuncture group (AG) and sham acupuncture group (SAG), and a control group (CG). The CG received the same acupuncture intervention as the AG, and the SAG received sham acupuncture, with 14 interventions in each group. The level of consciousness of patients with ICH was assessed and serum BDNF levels were measured in all three groups before the intervention and at 3 weeks after onset, and the level of consciousness and outcomes were assessed at 12 weeks after onset.ResultsAfter the intervention, the level of consciousness of the AG improved significantly (P < 0.05); the BDNF level of only the AG increased significantly (P < 0.05); the changes in Glasgow Coma Scale (GCS) score and BDNF level were significantly greater in the AG than in the SAG (P < 0.05), especially for locomotion (P < 0.05). At 12 weeks post-onset, the AG showed better outcomes and recovery of consciousness than the SAG (P < 0.05).https://www.frontiersin.org/articles/10.3389/fnins.2023.1167620/fullacupunctureintracerebral hemorrhagebrain-derived neurotrophic factor (BDNF)strokeprognosis |
| spellingShingle | Lingcong Li Xiujing Wang Jiaxun Guo Yilin Chen Zhenyu Wang Effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum BDNF: a randomized controlled trial Frontiers in Neuroscience acupuncture intracerebral hemorrhage brain-derived neurotrophic factor (BDNF) stroke prognosis |
| title | Effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum BDNF: a randomized controlled trial |
| title_full | Effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum BDNF: a randomized controlled trial |
| title_fullStr | Effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum BDNF: a randomized controlled trial |
| title_full_unstemmed | Effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum BDNF: a randomized controlled trial |
| title_short | Effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum BDNF: a randomized controlled trial |
| title_sort | effect of acupuncture in the acute phase of intracerebral hemorrhage on the prognosis and serum bdnf a randomized controlled trial |
| topic | acupuncture intracerebral hemorrhage brain-derived neurotrophic factor (BDNF) stroke prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1167620/full |
| work_keys_str_mv | AT lingcongli effectofacupunctureintheacutephaseofintracerebralhemorrhageontheprognosisandserumbdnfarandomizedcontrolledtrial AT xiujingwang effectofacupunctureintheacutephaseofintracerebralhemorrhageontheprognosisandserumbdnfarandomizedcontrolledtrial AT jiaxunguo effectofacupunctureintheacutephaseofintracerebralhemorrhageontheprognosisandserumbdnfarandomizedcontrolledtrial AT yilinchen effectofacupunctureintheacutephaseofintracerebralhemorrhageontheprognosisandserumbdnfarandomizedcontrolledtrial AT zhenyuwang effectofacupunctureintheacutephaseofintracerebralhemorrhageontheprognosisandserumbdnfarandomizedcontrolledtrial |