Production of radiometals in liquid targets
Abstract Over the last several years, the use of radiometals has gained increasing relevance in supporting the continuous development of new, complementary and more specific biological targeting agents. Radiopharmaceuticals labelled with radiometals from elements such as Tc, Zr, Y, Ga and Cu receive...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-01-01
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| Series: | EJNMMI Radiopharmacy and Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41181-019-0088-x |
| _version_ | 1818970916803051520 |
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| author | Sergio J. C. do Carmo Peter J. H. Scott Francisco Alves |
| author_facet | Sergio J. C. do Carmo Peter J. H. Scott Francisco Alves |
| author_sort | Sergio J. C. do Carmo |
| collection | DOAJ |
| description | Abstract Over the last several years, the use of radiometals has gained increasing relevance in supporting the continuous development of new, complementary and more specific biological targeting agents. Radiopharmaceuticals labelled with radiometals from elements such as Tc, Zr, Y, Ga and Cu received increasing attention as they find application in both diagnostic SPECT and PET imaging techniques and radiotherapeutic purposes. Such interest stems from the wide variety of radionuclides available with distinct and complementary nuclear decay characteristics to choose from with unequalled specificity, but can also be explained by growing demand in targeted radionuclide therapy. As a result, as routine supply of these radiometals becomes mandatory, studies describing their production processes have expanded rapidly. Although most radiometals are traditionally provided by the irradiation of solid targets in specialized cyclotrons, recently developed techniques for producing radiometals through the irradiation of liquid targets have received growing attention due to compatibility with commonly available small medical cyclotrons, promising characteristics and encouraging results. Irradiating liquid targets to produce radiometals appears as a fast, reliable, convenient and cost-efficient alternative to the conventional solid target techniques, characterized by complex and time-consuming pre- and post-irradiation target handling. Production of radiometals in liquid targets incorporated to complete manufacturing processes for daily routine is already recognized as a viable alternative and complementary supply methodology to existing solid target based infrastructures to satisfy growing clinical demands. For instance, several sites already use the approach to produce 68Ga-radiopharmaceuticals for clinical use. This review article covers the production of common radiometals with clinical potential through the irradiation liquid targets. A comparison with the traditional solid target irradiation methods is presented when relevant. |
| first_indexed | 2024-12-20T14:44:05Z |
| format | Article |
| id | doaj.art-0b1b73002b6d4086bff2865cbce07771 |
| institution | Directory Open Access Journal |
| issn | 2365-421X |
| language | English |
| last_indexed | 2024-12-20T14:44:05Z |
| publishDate | 2020-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Radiopharmacy and Chemistry |
| spelling | doaj.art-0b1b73002b6d4086bff2865cbce077712022-12-21T19:37:11ZengSpringerOpenEJNMMI Radiopharmacy and Chemistry2365-421X2020-01-015112110.1186/s41181-019-0088-xProduction of radiometals in liquid targetsSergio J. C. do Carmo0Peter J. H. Scott1Francisco Alves2ICNAS — Produção, Pólo das Ciências da Saúde, University of CoimbraDepartment of Radiology, University of MichiganICNAS – Institute for Nuclear Sciences Applied to Health, Pólo das Ciências da Saúde, University of CoimbraAbstract Over the last several years, the use of radiometals has gained increasing relevance in supporting the continuous development of new, complementary and more specific biological targeting agents. Radiopharmaceuticals labelled with radiometals from elements such as Tc, Zr, Y, Ga and Cu received increasing attention as they find application in both diagnostic SPECT and PET imaging techniques and radiotherapeutic purposes. Such interest stems from the wide variety of radionuclides available with distinct and complementary nuclear decay characteristics to choose from with unequalled specificity, but can also be explained by growing demand in targeted radionuclide therapy. As a result, as routine supply of these radiometals becomes mandatory, studies describing their production processes have expanded rapidly. Although most radiometals are traditionally provided by the irradiation of solid targets in specialized cyclotrons, recently developed techniques for producing radiometals through the irradiation of liquid targets have received growing attention due to compatibility with commonly available small medical cyclotrons, promising characteristics and encouraging results. Irradiating liquid targets to produce radiometals appears as a fast, reliable, convenient and cost-efficient alternative to the conventional solid target techniques, characterized by complex and time-consuming pre- and post-irradiation target handling. Production of radiometals in liquid targets incorporated to complete manufacturing processes for daily routine is already recognized as a viable alternative and complementary supply methodology to existing solid target based infrastructures to satisfy growing clinical demands. For instance, several sites already use the approach to produce 68Ga-radiopharmaceuticals for clinical use. This review article covers the production of common radiometals with clinical potential through the irradiation liquid targets. A comparison with the traditional solid target irradiation methods is presented when relevant.https://doi.org/10.1186/s41181-019-0088-xCyclotronRadioisotope productionLiquid targetRadiometals |
| spellingShingle | Sergio J. C. do Carmo Peter J. H. Scott Francisco Alves Production of radiometals in liquid targets EJNMMI Radiopharmacy and Chemistry Cyclotron Radioisotope production Liquid target Radiometals |
| title | Production of radiometals in liquid targets |
| title_full | Production of radiometals in liquid targets |
| title_fullStr | Production of radiometals in liquid targets |
| title_full_unstemmed | Production of radiometals in liquid targets |
| title_short | Production of radiometals in liquid targets |
| title_sort | production of radiometals in liquid targets |
| topic | Cyclotron Radioisotope production Liquid target Radiometals |
| url | https://doi.org/10.1186/s41181-019-0088-x |
| work_keys_str_mv | AT sergiojcdocarmo productionofradiometalsinliquidtargets AT peterjhscott productionofradiometalsinliquidtargets AT franciscoalves productionofradiometalsinliquidtargets |