Risk Factors and Prevention of Perioperative Venous Thromboembolism After Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy: An Analysis of 820 Cases
Objective To analyze the independent risk factors for perioperative venous thromboembolism (VTE) after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy(HIPEC), and to develop an integrated VTE prevention strategy. Methods The comprehensive database of CRS+HIPEC was first sy...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2019-02-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1353.htm |
| _version_ | 1818176841394946048 |
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| author | LI Xinbao JI Zhonghe ZHANG Yanbin LIU Gang LI Bing AN Songlin YU Yang ZHANG Kai LIN Yulin LI Yan |
| author_facet | LI Xinbao JI Zhonghe ZHANG Yanbin LIU Gang LI Bing AN Songlin YU Yang ZHANG Kai LIN Yulin LI Yan |
| author_sort | LI Xinbao |
| collection | DOAJ |
| description | Objective To analyze the independent risk factors for perioperative venous thromboembolism (VTE) after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy(HIPEC), and to develop an integrated VTE prevention strategy. Methods The comprehensive database of CRS+HIPEC was first systematically investigated to analyze the risk factors for VTE, and univariate and multivariate analyses were conducted to screen independent risk factors for VTE. An integrated VTE prevention strategy combining physiotherapy and pharmaceutical treatment was developed and applied to the patients. Results Among the 820 patients treated with CRS+HIPEC in the database, 14(1.7%) patients developed VTE in the perioperative period, including 6(0.7%) patients with asymptomatic VTE events and 8(1.0%) patients with 9 symptomatic events. No VTE-related death occurred. Univariate analysis revealed 5 high risk factors: old age(P=0.043), overweight(P=0.023), previous VTE-history(P=0.001), preoperative VTE(P=0.008) and vascular tumor thrombus(P=0.036). Multivariate analysis confirmed two independent risk factors: previous VTE history(OR=13.744, 95%CI: 2.391-64.455) and vascular tumor thrombus(OR=5.858, 95%CI: 1.028-33.387). Conclusion Previous VTE history and vascular tumor thrombus are independent risk factors for peritoneal cancer(PC) patients after CRS+HIPEC. Physiotherapy-based integrated prevention and treatment strategy could help prevent VTE. |
| first_indexed | 2024-12-11T20:22:36Z |
| format | Article |
| id | doaj.art-0b1c0164412341c2bbdcc9db95e35d9c |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-11T20:22:36Z |
| publishDate | 2019-02-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-0b1c0164412341c2bbdcc9db95e35d9c2022-12-22T00:52:01ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782019-02-0146212112610.3971/j.issn.1000-8578.2019.18.13538578.2019.18.1353Risk Factors and Prevention of Perioperative Venous Thromboembolism After Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy: An Analysis of 820 CasesLI Xinbao0JI Zhonghe1ZHANG Yanbin2LIU Gang3LI Bing4AN Songlin5YU Yang6ZHANG Kai7LIN Yulin8LI Yan9Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaObjective To analyze the independent risk factors for perioperative venous thromboembolism (VTE) after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy(HIPEC), and to develop an integrated VTE prevention strategy. Methods The comprehensive database of CRS+HIPEC was first systematically investigated to analyze the risk factors for VTE, and univariate and multivariate analyses were conducted to screen independent risk factors for VTE. An integrated VTE prevention strategy combining physiotherapy and pharmaceutical treatment was developed and applied to the patients. Results Among the 820 patients treated with CRS+HIPEC in the database, 14(1.7%) patients developed VTE in the perioperative period, including 6(0.7%) patients with asymptomatic VTE events and 8(1.0%) patients with 9 symptomatic events. No VTE-related death occurred. Univariate analysis revealed 5 high risk factors: old age(P=0.043), overweight(P=0.023), previous VTE-history(P=0.001), preoperative VTE(P=0.008) and vascular tumor thrombus(P=0.036). Multivariate analysis confirmed two independent risk factors: previous VTE history(OR=13.744, 95%CI: 2.391-64.455) and vascular tumor thrombus(OR=5.858, 95%CI: 1.028-33.387). Conclusion Previous VTE history and vascular tumor thrombus are independent risk factors for peritoneal cancer(PC) patients after CRS+HIPEC. Physiotherapy-based integrated prevention and treatment strategy could help prevent VTE.http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1353.htmcytoreductive surgeryhyperthermic intraperitoneal chemotherapyvenous thromboembolismintegrated vte prevention strategy |
| spellingShingle | LI Xinbao JI Zhonghe ZHANG Yanbin LIU Gang LI Bing AN Songlin YU Yang ZHANG Kai LIN Yulin LI Yan Risk Factors and Prevention of Perioperative Venous Thromboembolism After Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy: An Analysis of 820 Cases Zhongliu Fangzhi Yanjiu cytoreductive surgery hyperthermic intraperitoneal chemotherapy venous thromboembolism integrated vte prevention strategy |
| title | Risk Factors and Prevention of Perioperative Venous Thromboembolism After Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy: An Analysis of 820 Cases |
| title_full | Risk Factors and Prevention of Perioperative Venous Thromboembolism After Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy: An Analysis of 820 Cases |
| title_fullStr | Risk Factors and Prevention of Perioperative Venous Thromboembolism After Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy: An Analysis of 820 Cases |
| title_full_unstemmed | Risk Factors and Prevention of Perioperative Venous Thromboembolism After Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy: An Analysis of 820 Cases |
| title_short | Risk Factors and Prevention of Perioperative Venous Thromboembolism After Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy: An Analysis of 820 Cases |
| title_sort | risk factors and prevention of perioperative venous thromboembolism after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy an analysis of 820 cases |
| topic | cytoreductive surgery hyperthermic intraperitoneal chemotherapy venous thromboembolism integrated vte prevention strategy |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1353.htm |
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