Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant?
The Bethesda classification system for thyroid fine needle aspirate (FNA) is used to predict the risk of malignancy and to guide the management of thyroid nodules. We postulated that thyroid malignancies characterized as Bethesda III on FNA have more aggressive features than those classified as Beth...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/9/2563 |
| _version_ | 1797554180432330752 |
|---|---|
| author | Sena Turkdogan Marc Pusztaszeri Veronique-Isabelle Forest Michael P. Hier Richard J. Payne |
| author_facet | Sena Turkdogan Marc Pusztaszeri Veronique-Isabelle Forest Michael P. Hier Richard J. Payne |
| author_sort | Sena Turkdogan |
| collection | DOAJ |
| description | The Bethesda classification system for thyroid fine needle aspirate (FNA) is used to predict the risk of malignancy and to guide the management of thyroid nodules. We postulated that thyroid malignancies characterized as Bethesda III on FNA have more aggressive features than those classified as Bethesda IV. A retrospective chart review was performed to identify those who underwent thyroid surgery at a single tertiary hospital setting between 2015 and 2020. Associations between Bethesda category, molecular genetic test results, and histopathologic findings were examined. Out of 628 surgeries that were performed, 199 (54.2%) Bethesda III nodules and 216 (82.8%) Bethesda IV nodules were malignant. Of those that were malignant, 37 (18.6%) and 22 (10.2%) Bethesda III and Bethesda IV nodules showed aggressive features, respectively (<i>p</i> value = 0.014). There was a proportionally increased number of aggressive features in extra-thyroidal extension, lymph nodes metastasis, and all aggressive subtypes of papillary thyroid cancer in the Bethesda III category. Although Bethesda IV nodules are much more likely to be malignant (<i>p</i> value = 0.002), our study suggests that Bethesda III nodules that are resected are more likely to have aggressive features than Bethesda IV nodules, with a statistically significant increase in the solid variant of papillary thyroid cancer and lymph node metastasis. |
| first_indexed | 2024-03-10T16:28:16Z |
| format | Article |
| id | doaj.art-0b1e21095d854ea081defbefbf14e685 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T16:28:16Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0b1e21095d854ea081defbefbf14e6852023-11-20T13:02:12ZengMDPI AGCancers2072-66942020-09-01129256310.3390/cancers12092563Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant?Sena Turkdogan0Marc Pusztaszeri1Veronique-Isabelle Forest2Michael P. Hier3Richard J. Payne4Department of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, CanadaDepartment of Pathology, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, CanadaDepartment of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, CanadaDepartment of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, CanadaDepartment of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, CanadaThe Bethesda classification system for thyroid fine needle aspirate (FNA) is used to predict the risk of malignancy and to guide the management of thyroid nodules. We postulated that thyroid malignancies characterized as Bethesda III on FNA have more aggressive features than those classified as Bethesda IV. A retrospective chart review was performed to identify those who underwent thyroid surgery at a single tertiary hospital setting between 2015 and 2020. Associations between Bethesda category, molecular genetic test results, and histopathologic findings were examined. Out of 628 surgeries that were performed, 199 (54.2%) Bethesda III nodules and 216 (82.8%) Bethesda IV nodules were malignant. Of those that were malignant, 37 (18.6%) and 22 (10.2%) Bethesda III and Bethesda IV nodules showed aggressive features, respectively (<i>p</i> value = 0.014). There was a proportionally increased number of aggressive features in extra-thyroidal extension, lymph nodes metastasis, and all aggressive subtypes of papillary thyroid cancer in the Bethesda III category. Although Bethesda IV nodules are much more likely to be malignant (<i>p</i> value = 0.002), our study suggests that Bethesda III nodules that are resected are more likely to have aggressive features than Bethesda IV nodules, with a statistically significant increase in the solid variant of papillary thyroid cancer and lymph node metastasis.https://www.mdpi.com/2072-6694/12/9/2563thyroid cancerthyroid noduleBethesdamolecular testing |
| spellingShingle | Sena Turkdogan Marc Pusztaszeri Veronique-Isabelle Forest Michael P. Hier Richard J. Payne Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant? Cancers thyroid cancer thyroid nodule Bethesda molecular testing |
| title | Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant? |
| title_full | Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant? |
| title_fullStr | Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant? |
| title_full_unstemmed | Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant? |
| title_short | Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant? |
| title_sort | are bethesda iii thyroid nodules more aggressive than bethesda iv thyroid nodules when found to be malignant |
| topic | thyroid cancer thyroid nodule Bethesda molecular testing |
| url | https://www.mdpi.com/2072-6694/12/9/2563 |
| work_keys_str_mv | AT senaturkdogan arebethesdaiiithyroidnodulesmoreaggressivethanbethesdaivthyroidnoduleswhenfoundtobemalignant AT marcpusztaszeri arebethesdaiiithyroidnodulesmoreaggressivethanbethesdaivthyroidnoduleswhenfoundtobemalignant AT veroniqueisabelleforest arebethesdaiiithyroidnodulesmoreaggressivethanbethesdaivthyroidnoduleswhenfoundtobemalignant AT michaelphier arebethesdaiiithyroidnodulesmoreaggressivethanbethesdaivthyroidnoduleswhenfoundtobemalignant AT richardjpayne arebethesdaiiithyroidnodulesmoreaggressivethanbethesdaivthyroidnoduleswhenfoundtobemalignant |