The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter?
Stroke has become a significant cause of death and disability globally. Along with the transition of the world's aging population, the incidence of acute ischemic stroke is increasing year by year. Even with effective treatment modalities, patients are not guaranteed to have a good prognosis. T...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.928802/full |
| _version_ | 1811221133818593280 |
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| author | Yujia Yan Yujia Yan Xiqiang Zhang Xingwei An Xingwei An Wanpeng Fan Jingbo Liang Bin Luo Hecheng Ren Ying Huang |
| author_facet | Yujia Yan Yujia Yan Xiqiang Zhang Xingwei An Xingwei An Wanpeng Fan Jingbo Liang Bin Luo Hecheng Ren Ying Huang |
| author_sort | Yujia Yan |
| collection | DOAJ |
| description | Stroke has become a significant cause of death and disability globally. Along with the transition of the world's aging population, the incidence of acute ischemic stroke is increasing year by year. Even with effective treatment modalities, patients are not guaranteed to have a good prognosis. The treatment model combining intravenous thrombolysis/endovascular therapy and neuroprotection is gradually being recognized. After the clinical translation of pharmacological neuroprotective agents failed, non-pharmacological physical neuroprotective agents have rekindled hope. We performed a literature review using the National Center for Biotechnology Information (NCBI) PubMed database for studies that focused on the application of hyperbaric oxygen therapy in acute ischemic stroke. In this review, we present the history and mechanisms of hyperbaric oxygen therapy, focusing on the current status, outcomes, current challenges, perspective, safety, and complications of the application of hyperbaric oxygen in animal experiments and human clinical trials. Hyperbaric oxygen therapy, a non-pharmacological treatment, can improve the oxygenation level at the ischemic lesions in increased dissolved oxygen and oxygen diffusion radius to achieve salvage of neurological function, giving a new meaning to acute ischemic stroke. |
| first_indexed | 2024-04-12T07:54:03Z |
| format | Article |
| id | doaj.art-0b2088ddcfa14aa98e2395bc07c2647b |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T07:54:03Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0b2088ddcfa14aa98e2395bc07c2647b2022-12-22T03:41:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.928802928802The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter?Yujia Yan0Yujia Yan1Xiqiang Zhang2Xingwei An3Xingwei An4Wanpeng Fan5Jingbo Liang6Bin Luo7Hecheng Ren8Ying Huang9Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurosurgery, Third People's Hospital of Xining City, Xining, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaTianjin Center for Brain Science, Tianjin, ChinaDepartment of Neurosurgery, Third People's Hospital of Xining City, Xining, ChinaDepartment of Neurosurgery, Third People's Hospital of Xining City, Xining, ChinaDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, ChinaStroke has become a significant cause of death and disability globally. Along with the transition of the world's aging population, the incidence of acute ischemic stroke is increasing year by year. Even with effective treatment modalities, patients are not guaranteed to have a good prognosis. The treatment model combining intravenous thrombolysis/endovascular therapy and neuroprotection is gradually being recognized. After the clinical translation of pharmacological neuroprotective agents failed, non-pharmacological physical neuroprotective agents have rekindled hope. We performed a literature review using the National Center for Biotechnology Information (NCBI) PubMed database for studies that focused on the application of hyperbaric oxygen therapy in acute ischemic stroke. In this review, we present the history and mechanisms of hyperbaric oxygen therapy, focusing on the current status, outcomes, current challenges, perspective, safety, and complications of the application of hyperbaric oxygen in animal experiments and human clinical trials. Hyperbaric oxygen therapy, a non-pharmacological treatment, can improve the oxygenation level at the ischemic lesions in increased dissolved oxygen and oxygen diffusion radius to achieve salvage of neurological function, giving a new meaning to acute ischemic stroke.https://www.frontiersin.org/articles/10.3389/fneur.2022.928802/fullstrokeacute ischemic strokehyperbaric oxygen therapyneuroprotectionclinical application |
| spellingShingle | Yujia Yan Yujia Yan Xiqiang Zhang Xingwei An Xingwei An Wanpeng Fan Jingbo Liang Bin Luo Hecheng Ren Ying Huang The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter? Frontiers in Neurology stroke acute ischemic stroke hyperbaric oxygen therapy neuroprotection clinical application |
| title | The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter? |
| title_full | The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter? |
| title_fullStr | The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter? |
| title_full_unstemmed | The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter? |
| title_short | The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter? |
| title_sort | application and perspective of hyperbaric oxygen therapy in acute ischemic stroke from the bench to a starter |
| topic | stroke acute ischemic stroke hyperbaric oxygen therapy neuroprotection clinical application |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.928802/full |
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