Cerebral tumor with hemi-dural enhancement as unique presentation of multiple myeloma: A case report
Introduction: Intracranial multiple myeloma (MM) is a rare manifestation of MM, a malignant plasma cell disorder that primarily affects bone marrow. Dural involvement in MM is even rarer and can manifest as a dural mass. We present a case of MM presenting as an intracranial dural tumor with primary...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Brain and Spine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772529423010184 |
| _version_ | 1797378576602890240 |
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| author | Rick H.G.J. van Lanen Sandra M.H. Huijs Alida A. Postma Roel H.L. Haeren |
| author_facet | Rick H.G.J. van Lanen Sandra M.H. Huijs Alida A. Postma Roel H.L. Haeren |
| author_sort | Rick H.G.J. van Lanen |
| collection | DOAJ |
| description | Introduction: Intracranial multiple myeloma (MM) is a rare manifestation of MM, a malignant plasma cell disorder that primarily affects bone marrow. Dural involvement in MM is even rarer and can manifest as a dural mass. We present a case of MM presenting as an intracranial dural tumor with primary hemi-dural involvement. Research question: This case report aims to investigate the clinical presentation, diagnostic challenges, and treatment approaches for intracranial multiple myeloma, with a focus on the extensive hemi-dural thickening and enhancement seen in this case. Material and methods: A 73-year-old male presented with progressive dysphasia and weakness. MRI revealed a solid left frontal mass with significant mass-effect. Hemi-dural thickening and enhancement was present along with invasion of the skull. The patient underwent surgical resection of the tumor with dural and bone reconstruction. Results: Histopathological examination confirmed MM diagnosis. Chemotherapy was started. Follow-up MRI showed complete tumor resection, but extensive hemi-dural thickening and enhancement persisted. Postoperative radiation therapy was considered. Discussion and conclusion: MM with primary dural involvement is rare and poses diagnostic challenges. Postoperative treatment involves chemotherapy, the role of surgery and radiotherapy is not established. The extensive hemi-dural thickening and enhancement observed in this case require further investigation, and a wait-and-scan policy was recommended instead of radiotherapy. |
| first_indexed | 2024-03-08T20:09:44Z |
| format | Article |
| id | doaj.art-0b22f323375e4d4d88e5fa71119ff4b0 |
| institution | Directory Open Access Journal |
| issn | 2772-5294 |
| language | English |
| last_indexed | 2024-03-08T20:09:44Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain and Spine |
| spelling | doaj.art-0b22f323375e4d4d88e5fa71119ff4b02023-12-23T05:23:11ZengElsevierBrain and Spine2772-52942024-01-014102730Cerebral tumor with hemi-dural enhancement as unique presentation of multiple myeloma: A case reportRick H.G.J. van Lanen0Sandra M.H. Huijs1Alida A. Postma2Roel H.L. Haeren3Department of Neurosurgery, Maastricht University Medical Centre+, Maastricht, the Netherlands; School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands; Corresponding author. Maastricht University Medical Centre+, Department of Neurosurgery, PO box 5800, 6202 AZ, Maastricht, the Netherlands.Department of Neurology, Maastricht University Medical Centre+, Maastricht, the NetherlandsSchool for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands; Department of Radiology, Maastricht University Medical Centre+, Maastricht, the NetherlandsDepartment of Neurosurgery, Maastricht University Medical Centre+, Maastricht, the Netherlands; School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the NetherlandsIntroduction: Intracranial multiple myeloma (MM) is a rare manifestation of MM, a malignant plasma cell disorder that primarily affects bone marrow. Dural involvement in MM is even rarer and can manifest as a dural mass. We present a case of MM presenting as an intracranial dural tumor with primary hemi-dural involvement. Research question: This case report aims to investigate the clinical presentation, diagnostic challenges, and treatment approaches for intracranial multiple myeloma, with a focus on the extensive hemi-dural thickening and enhancement seen in this case. Material and methods: A 73-year-old male presented with progressive dysphasia and weakness. MRI revealed a solid left frontal mass with significant mass-effect. Hemi-dural thickening and enhancement was present along with invasion of the skull. The patient underwent surgical resection of the tumor with dural and bone reconstruction. Results: Histopathological examination confirmed MM diagnosis. Chemotherapy was started. Follow-up MRI showed complete tumor resection, but extensive hemi-dural thickening and enhancement persisted. Postoperative radiation therapy was considered. Discussion and conclusion: MM with primary dural involvement is rare and poses diagnostic challenges. Postoperative treatment involves chemotherapy, the role of surgery and radiotherapy is not established. The extensive hemi-dural thickening and enhancement observed in this case require further investigation, and a wait-and-scan policy was recommended instead of radiotherapy.http://www.sciencedirect.com/science/article/pii/S2772529423010184Case reportDura materIntracranialMultiple myelomaPlasmacytoma |
| spellingShingle | Rick H.G.J. van Lanen Sandra M.H. Huijs Alida A. Postma Roel H.L. Haeren Cerebral tumor with hemi-dural enhancement as unique presentation of multiple myeloma: A case report Brain and Spine Case report Dura mater Intracranial Multiple myeloma Plasmacytoma |
| title | Cerebral tumor with hemi-dural enhancement as unique presentation of multiple myeloma: A case report |
| title_full | Cerebral tumor with hemi-dural enhancement as unique presentation of multiple myeloma: A case report |
| title_fullStr | Cerebral tumor with hemi-dural enhancement as unique presentation of multiple myeloma: A case report |
| title_full_unstemmed | Cerebral tumor with hemi-dural enhancement as unique presentation of multiple myeloma: A case report |
| title_short | Cerebral tumor with hemi-dural enhancement as unique presentation of multiple myeloma: A case report |
| title_sort | cerebral tumor with hemi dural enhancement as unique presentation of multiple myeloma a case report |
| topic | Case report Dura mater Intracranial Multiple myeloma Plasmacytoma |
| url | http://www.sciencedirect.com/science/article/pii/S2772529423010184 |
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