Description and Nomenclature of Neisseria meningitidis Capsule Locus
Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysacchar...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2013-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/19/4/11-1799_article |
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| author | Odile B. Harrison Heike Claus Ying Jiang Julia S. Bennett Holly B. Bratcher Keith A. Jolley Craig Corton Rory Care Jan T. Poolman Wendell D. Zollinger Carl E. Frasch David S. Stephens Ian Feavers Matthias Frosch Julian Parkhill Ulrich Vogel Michael A. Quail Stephen D. Bentley Martin C.J. Maiden |
| author_facet | Odile B. Harrison Heike Claus Ying Jiang Julia S. Bennett Holly B. Bratcher Keith A. Jolley Craig Corton Rory Care Jan T. Poolman Wendell D. Zollinger Carl E. Frasch David S. Stephens Ian Feavers Matthias Frosch Julian Parkhill Ulrich Vogel Michael A. Quail Stephen D. Bentley Martin C.J. Maiden |
| author_sort | Odile B. Harrison |
| collection | DOAJ |
| description | Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference. |
| first_indexed | 2024-12-12T01:08:33Z |
| format | Article |
| id | doaj.art-0b24a4052f834bb29e0e0c22a5d7d14f |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T01:08:33Z |
| publishDate | 2013-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-0b24a4052f834bb29e0e0c22a5d7d14f2022-12-22T00:43:31ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592013-04-0119456657310.3201/eid1904.111799Description and Nomenclature of Neisseria meningitidis Capsule LocusOdile B. HarrisonHeike ClausYing JiangJulia S. BennettHolly B. BratcherKeith A. JolleyCraig CortonRory CareJan T. PoolmanWendell D. ZollingerCarl E. FraschDavid S. StephensIan FeaversMatthias FroschJulian ParkhillUlrich VogelMichael A. QuailStephen D. BentleyMartin C.J. MaidenPathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.https://wwwnc.cdc.gov/eid/article/19/4/11-1799_articleNeisseria meningitidiscapsuleserogroupbacterianomenclatureChina |
| spellingShingle | Odile B. Harrison Heike Claus Ying Jiang Julia S. Bennett Holly B. Bratcher Keith A. Jolley Craig Corton Rory Care Jan T. Poolman Wendell D. Zollinger Carl E. Frasch David S. Stephens Ian Feavers Matthias Frosch Julian Parkhill Ulrich Vogel Michael A. Quail Stephen D. Bentley Martin C.J. Maiden Description and Nomenclature of Neisseria meningitidis Capsule Locus Emerging Infectious Diseases Neisseria meningitidis capsule serogroup bacteria nomenclature China |
| title | Description and Nomenclature of Neisseria meningitidis Capsule Locus |
| title_full | Description and Nomenclature of Neisseria meningitidis Capsule Locus |
| title_fullStr | Description and Nomenclature of Neisseria meningitidis Capsule Locus |
| title_full_unstemmed | Description and Nomenclature of Neisseria meningitidis Capsule Locus |
| title_short | Description and Nomenclature of Neisseria meningitidis Capsule Locus |
| title_sort | description and nomenclature of neisseria meningitidis capsule locus |
| topic | Neisseria meningitidis capsule serogroup bacteria nomenclature China |
| url | https://wwwnc.cdc.gov/eid/article/19/4/11-1799_article |
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