Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative Review
Rheumatoid arthritis (RA) is considered a systemic inflammatory disease marked by polyarthritis which affects the joints symmetrically, leading to progressive damage of the bone structure and eventually joint deformity. Lung involvement is the most prevalent extra-articular feature of RA, affecting...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/6/1367 |
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| author | Alesandra Florescu Florin Liviu Gherghina Anca Emanuela Mușetescu Vlad Pădureanu Anca Roșu Mirela Marinela Florescu Cristina Criveanu Lucian-Mihai Florescu Anca Bobircă |
| author_facet | Alesandra Florescu Florin Liviu Gherghina Anca Emanuela Mușetescu Vlad Pădureanu Anca Roșu Mirela Marinela Florescu Cristina Criveanu Lucian-Mihai Florescu Anca Bobircă |
| author_sort | Alesandra Florescu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is considered a systemic inflammatory disease marked by polyarthritis which affects the joints symmetrically, leading to progressive damage of the bone structure and eventually joint deformity. Lung involvement is the most prevalent extra-articular feature of RA, affecting 10–60% of patients with this disease. In this review, we aim to discuss the patterns of RA interstitial lung disease (ILD), the molecular mechanisms involved in the pathogenesis of ILD in RA, and also the therapeutic challenges in this particular extra-articular manifestation. The pathophysiology of RA-ILD has been linked to biomarkers such as anti-citrullinated protein antibodies (ACPAs), MUC5B mutation, Krebs von den Lungen 6 (KL-6), and other environmental factors such as smoking. Patients at the highest risk for RA-ILD and those most likely to advance will be identified using biomarkers. The hope is that finding biomarkers with good performance characteristics would help researchers better understand the pathophysiology of RA-ILD and, in turn, lead to the development of tailored therapeutics for this severe RA manifestation. |
| first_indexed | 2024-03-10T00:20:27Z |
| format | Article |
| id | doaj.art-0b2881230c5243a7ac894af6bbc6afa7 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:20:27Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0b2881230c5243a7ac894af6bbc6afa72023-11-23T15:43:38ZengMDPI AGBiomedicines2227-90592022-06-01106136710.3390/biomedicines10061367Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative ReviewAlesandra Florescu0Florin Liviu Gherghina1Anca Emanuela Mușetescu2Vlad Pădureanu3Anca Roșu4Mirela Marinela Florescu5Cristina Criveanu6Lucian-Mihai Florescu7Anca Bobircă8Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Physical Medicine and Rehabilitation, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Pathology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Radiology and Medical Imaging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Rheumatology and Internal Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaRheumatoid arthritis (RA) is considered a systemic inflammatory disease marked by polyarthritis which affects the joints symmetrically, leading to progressive damage of the bone structure and eventually joint deformity. Lung involvement is the most prevalent extra-articular feature of RA, affecting 10–60% of patients with this disease. In this review, we aim to discuss the patterns of RA interstitial lung disease (ILD), the molecular mechanisms involved in the pathogenesis of ILD in RA, and also the therapeutic challenges in this particular extra-articular manifestation. The pathophysiology of RA-ILD has been linked to biomarkers such as anti-citrullinated protein antibodies (ACPAs), MUC5B mutation, Krebs von den Lungen 6 (KL-6), and other environmental factors such as smoking. Patients at the highest risk for RA-ILD and those most likely to advance will be identified using biomarkers. The hope is that finding biomarkers with good performance characteristics would help researchers better understand the pathophysiology of RA-ILD and, in turn, lead to the development of tailored therapeutics for this severe RA manifestation.https://www.mdpi.com/2227-9059/10/6/1367rheumatoid arthritisinterstitial lung diseasebiomarkerstreatment |
| spellingShingle | Alesandra Florescu Florin Liviu Gherghina Anca Emanuela Mușetescu Vlad Pădureanu Anca Roșu Mirela Marinela Florescu Cristina Criveanu Lucian-Mihai Florescu Anca Bobircă Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative Review Biomedicines rheumatoid arthritis interstitial lung disease biomarkers treatment |
| title | Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative Review |
| title_full | Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative Review |
| title_fullStr | Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative Review |
| title_full_unstemmed | Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative Review |
| title_short | Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease—A Narrative Review |
| title_sort | novel biomarkers diagnostic and therapeutic approach in rheumatoid arthritis interstitial lung disease a narrative review |
| topic | rheumatoid arthritis interstitial lung disease biomarkers treatment |
| url | https://www.mdpi.com/2227-9059/10/6/1367 |
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