Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study
Abstract Objective The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese. Methods All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplificatio...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-08-01
|
| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-020-02273-1 |
| _version_ | 1818415118901313536 |
|---|---|
| author | Minh Duc Do Thao Phuong Mai Anh Duy Do Quang Dinh Nguyen Nghia Hieu Le Linh Gia Hoang Le Vu Anh Hoang Anh Ngoc Le Hung Quoc Le Pascal Richette Matthieu Resche-Rigon Thomas Bardin |
| author_facet | Minh Duc Do Thao Phuong Mai Anh Duy Do Quang Dinh Nguyen Nghia Hieu Le Linh Gia Hoang Le Vu Anh Hoang Anh Ngoc Le Hung Quoc Le Pascal Richette Matthieu Resche-Rigon Thomas Bardin |
| author_sort | Minh Duc Do |
| collection | DOAJ |
| description | Abstract Objective The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese. Methods All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by using the PG5801 Detection Kit (Pharmigene, Taipei). Patients with severe (SCARs) and mild (MCARs) CARs and controls were compared for differences in features prospectively collected, and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. Results On comparing 32 patients with SCARs and 395 tolerant controls, we identified eight strong risk factors: increased age (OR 15.1 [95% CI 5.8–40.1], P < 0.0001), female sex (OR 333 [40–43,453], P < 0.0001), allopurinol for asymptomatic hyperuricemia (OR 955 [120–125,847], P < 0.0001), allopurinol starting dose > 150 mg (OR 316 [101–122], P < 0.0001), diuretics intake (OR 304 [35–40,018], P < 0.0001), eGFR < 60 ml/min/1.73 m2 (OR 100 [32–353], P < 0.0001), history of allopurinol-induced skin reaction (OR 78 [6–10,808], P = 0.004), and HLA-B*58:01 carriage (OR 147 [45–746], P < 0.0001). HLA-B*58:01 allele frequency in controls was 7.3%. For MCARs (n = 74), risk factors were eGFR < 60 ml/min/1.73 m2 (OR 4.9 [1.61–14.6], P = 0.006), history of allopurinol-induced skin reaction (OR 27 [2–3777], P = 0.01), and asymptomatic hyperuricemia (OR 27 [2–3777], P = 0.01). Conclusion This study confirmed 8 risk factors, including HLA-B*58:01, for SCARs and identified 3 risk factors for MCARs in Kinh Vietnamese. HLA-B*58:01 genotyping could guide the indication for allopurinol in Kinh Vietnamese patients with gout. |
| first_indexed | 2024-12-14T11:29:55Z |
| format | Article |
| id | doaj.art-0b2a8f26f4b6475dbd2572047530e7a2 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-14T11:29:55Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-0b2a8f26f4b6475dbd2572047530e7a22022-12-21T23:03:20ZengBMCArthritis Research & Therapy1478-63622020-08-0122111010.1186/s13075-020-02273-1Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control studyMinh Duc Do0Thao Phuong Mai1Anh Duy Do2Quang Dinh Nguyen3Nghia Hieu Le4Linh Gia Hoang Le5Vu Anh Hoang6Anh Ngoc Le7Hung Quoc Le8Pascal Richette9Matthieu Resche-Rigon10Thomas Bardin11Center for Molecular Biomedicine, University of Medicine and PharmacyDepartment of Physiology, Pathophysiology and Immunology, Faculty of Medicine, University of Medicine and PharmacyDepartment of Physiology, Pathophysiology and Immunology, Pham Ngoc Thach University of MedicineFrench Vietnamese Research Center on Gout and Chronic Diseases, Vien Gut Medical CentreFrench Vietnamese Research Center on Gout and Chronic Diseases, Vien Gut Medical CentreCenter for Molecular Biomedicine, University of Medicine and PharmacyCenter for Molecular Biomedicine, University of Medicine and PharmacyDepartment of Scientific Research, Cho Ray HospitalDepartment of Tropical Disease, Cho Ray HospitalUniversité de Paris, U1132, INSERMUniversité de Paris, ECSTRRA Team U1153, INSERMFrench Vietnamese Research Center on Gout and Chronic Diseases, Vien Gut Medical CentreAbstract Objective The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese. Methods All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by using the PG5801 Detection Kit (Pharmigene, Taipei). Patients with severe (SCARs) and mild (MCARs) CARs and controls were compared for differences in features prospectively collected, and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. Results On comparing 32 patients with SCARs and 395 tolerant controls, we identified eight strong risk factors: increased age (OR 15.1 [95% CI 5.8–40.1], P < 0.0001), female sex (OR 333 [40–43,453], P < 0.0001), allopurinol for asymptomatic hyperuricemia (OR 955 [120–125,847], P < 0.0001), allopurinol starting dose > 150 mg (OR 316 [101–122], P < 0.0001), diuretics intake (OR 304 [35–40,018], P < 0.0001), eGFR < 60 ml/min/1.73 m2 (OR 100 [32–353], P < 0.0001), history of allopurinol-induced skin reaction (OR 78 [6–10,808], P = 0.004), and HLA-B*58:01 carriage (OR 147 [45–746], P < 0.0001). HLA-B*58:01 allele frequency in controls was 7.3%. For MCARs (n = 74), risk factors were eGFR < 60 ml/min/1.73 m2 (OR 4.9 [1.61–14.6], P = 0.006), history of allopurinol-induced skin reaction (OR 27 [2–3777], P = 0.01), and asymptomatic hyperuricemia (OR 27 [2–3777], P = 0.01). Conclusion This study confirmed 8 risk factors, including HLA-B*58:01, for SCARs and identified 3 risk factors for MCARs in Kinh Vietnamese. HLA-B*58:01 genotyping could guide the indication for allopurinol in Kinh Vietnamese patients with gout.http://link.springer.com/article/10.1186/s13075-020-02273-1GoutAllopurinolSkin reactionsKinh VietnameseRisk factorsHLA-B*58:01 |
| spellingShingle | Minh Duc Do Thao Phuong Mai Anh Duy Do Quang Dinh Nguyen Nghia Hieu Le Linh Gia Hoang Le Vu Anh Hoang Anh Ngoc Le Hung Quoc Le Pascal Richette Matthieu Resche-Rigon Thomas Bardin Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study Arthritis Research & Therapy Gout Allopurinol Skin reactions Kinh Vietnamese Risk factors HLA-B*58:01 |
| title | Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study |
| title_full | Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study |
| title_fullStr | Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study |
| title_full_unstemmed | Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study |
| title_short | Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study |
| title_sort | risk factors for cutaneous reactions to allopurinol in kinh vietnamese results from a case control study |
| topic | Gout Allopurinol Skin reactions Kinh Vietnamese Risk factors HLA-B*58:01 |
| url | http://link.springer.com/article/10.1186/s13075-020-02273-1 |
| work_keys_str_mv | AT minhducdo riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT thaophuongmai riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT anhduydo riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT quangdinhnguyen riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT nghiahieule riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT linhgiahoangle riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT vuanhhoang riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT anhngocle riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT hungquocle riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT pascalrichette riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT matthieurescherigon riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy AT thomasbardin riskfactorsforcutaneousreactionstoallopurinolinkinhvietnameseresultsfromacasecontrolstudy |