The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance
Objective: Since decreased brain-derived neurotrophic factor (BDNF) and increased dipeptidyl peptidase-4 (DPP4) activity have both been implicated in the pathogenesis of mild cognitive impairment (MCI), the aim of our study was to evaluate the association of MCI with plasma DPP4 activity to BDNF rat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00033/full |
| _version_ | 1819086074045005824 |
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| author | Liuping Xiao Bo Ge Xu Chen Bo Chen Linyuan Qin Xueping Hu Haidong Pan Yujie Chen Li Tian Yun Gao Tianpeng Zheng Tianpeng Zheng |
| author_facet | Liuping Xiao Bo Ge Xu Chen Bo Chen Linyuan Qin Xueping Hu Haidong Pan Yujie Chen Li Tian Yun Gao Tianpeng Zheng Tianpeng Zheng |
| author_sort | Liuping Xiao |
| collection | DOAJ |
| description | Objective: Since decreased brain-derived neurotrophic factor (BDNF) and increased dipeptidyl peptidase-4 (DPP4) activity have both been implicated in the pathogenesis of mild cognitive impairment (MCI), the aim of our study was to evaluate the association of MCI with plasma DPP4 activity to BDNF ratio (DBR) in an elderly population with normal glucose tolerance.Methods: We cross-sectionally measured C-reactive protein, interleukin-6, nitrotyrosine, 8-iso-PGF2a, DPP4 activity BDNF and calculated the DBR in a total of 1,066 elderly participants in China. MCI was determined by the Montreal Cognitive Assessment and finally confirmed by neurologists.Results: An inverse correlation was found between DPP4 activity and BDNF (r = -0.456, P < 0.001) and this inverse correlation was partly mediated by nitrotyrosine and 8-iso-PGF2a. Across rising quartiles of DBR, nitrotyrosine, 8-iso-PGF2a, C-reactive protein and interleukin-6 progressively increased, whereas the Montreal Cognitive Assessment score progressively decreased. Subjects in the lowest quartile of BDNF and highest quartiles of DBR and DPP4 activity, had higher MCI risk compared with subjects in the highest quartile of the BDNF and lowest quartiles of DBR and DPP4 activity, respectively (all P < 0.05). The odds ratio for MCI became more pronounced with decreased BDNF and increased DPP4.Conclusion: In conclusion, a negative correlation was found between DPP4 activity and BDNF, and this negative correlation was partly mediated by oxidative stress, not inflammation. The DBR was positively associated with MCI and thus may be used as a novel risk biomarker for MCI in an elderly population with normal glucose tolerance. |
| first_indexed | 2024-12-21T21:14:28Z |
| format | Article |
| id | doaj.art-0b2cf450c0284b3689fcad0b5f094cf4 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-21T21:14:28Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-0b2cf450c0284b3689fcad0b5f094cf42022-12-21T18:50:03ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-03-011110.3389/fnagi.2019.00033436161The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose ToleranceLiuping Xiao0Bo Ge1Xu Chen2Bo Chen3Linyuan Qin4Xueping Hu5Haidong Pan6Yujie Chen7Li Tian8Yun Gao9Tianpeng Zheng10Tianpeng Zheng11Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Urology, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaCollege of Pharmacy, Guilin Medical University, Guilin, ChinaDepartment of Human Anatomy, Southwest Medical University, Luzhou, ChinaDepartment of Epidemiology and Health Statistics, Guilin Medical University, Guilin, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Chengdu, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Chengdu, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaCenter of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin, ChinaObjective: Since decreased brain-derived neurotrophic factor (BDNF) and increased dipeptidyl peptidase-4 (DPP4) activity have both been implicated in the pathogenesis of mild cognitive impairment (MCI), the aim of our study was to evaluate the association of MCI with plasma DPP4 activity to BDNF ratio (DBR) in an elderly population with normal glucose tolerance.Methods: We cross-sectionally measured C-reactive protein, interleukin-6, nitrotyrosine, 8-iso-PGF2a, DPP4 activity BDNF and calculated the DBR in a total of 1,066 elderly participants in China. MCI was determined by the Montreal Cognitive Assessment and finally confirmed by neurologists.Results: An inverse correlation was found between DPP4 activity and BDNF (r = -0.456, P < 0.001) and this inverse correlation was partly mediated by nitrotyrosine and 8-iso-PGF2a. Across rising quartiles of DBR, nitrotyrosine, 8-iso-PGF2a, C-reactive protein and interleukin-6 progressively increased, whereas the Montreal Cognitive Assessment score progressively decreased. Subjects in the lowest quartile of BDNF and highest quartiles of DBR and DPP4 activity, had higher MCI risk compared with subjects in the highest quartile of the BDNF and lowest quartiles of DBR and DPP4 activity, respectively (all P < 0.05). The odds ratio for MCI became more pronounced with decreased BDNF and increased DPP4.Conclusion: In conclusion, a negative correlation was found between DPP4 activity and BDNF, and this negative correlation was partly mediated by oxidative stress, not inflammation. The DBR was positively associated with MCI and thus may be used as a novel risk biomarker for MCI in an elderly population with normal glucose tolerance.https://www.frontiersin.org/article/10.3389/fnagi.2019.00033/fullmild cognitive impairmentDPP4 activity to BDNF ratiooxidative stressinflammationnormal glucose tolerance |
| spellingShingle | Liuping Xiao Bo Ge Xu Chen Bo Chen Linyuan Qin Xueping Hu Haidong Pan Yujie Chen Li Tian Yun Gao Tianpeng Zheng Tianpeng Zheng The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance Frontiers in Aging Neuroscience mild cognitive impairment DPP4 activity to BDNF ratio oxidative stress inflammation normal glucose tolerance |
| title | The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance |
| title_full | The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance |
| title_fullStr | The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance |
| title_full_unstemmed | The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance |
| title_short | The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance |
| title_sort | relationship between plasma dpp4 activity to bdnf ratio and mild cognitive impairment in elderly population with normal glucose tolerance |
| topic | mild cognitive impairment DPP4 activity to BDNF ratio oxidative stress inflammation normal glucose tolerance |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00033/full |
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