Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives
The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/7/1392 |
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| author | Ditte S. Kornum Astrid J. Terkelsen Davide Bertoli Mette W. Klinge Katrine L. Høyer Huda H. A. Kufaishi Per Borghammer Asbjørn M. Drewes Christina Brock Klaus Krogh |
| author_facet | Ditte S. Kornum Astrid J. Terkelsen Davide Bertoli Mette W. Klinge Katrine L. Høyer Huda H. A. Kufaishi Per Borghammer Asbjørn M. Drewes Christina Brock Klaus Krogh |
| author_sort | Ditte S. Kornum |
| collection | DOAJ |
| description | The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson’s disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method. |
| first_indexed | 2024-03-10T12:44:07Z |
| format | Article |
| id | doaj.art-0b2db0ac5b8a4f2b8fdd0ffd66a819b0 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:44:07Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0b2db0ac5b8a4f2b8fdd0ffd66a819b02023-11-21T13:33:48ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01107139210.3390/jcm10071392Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future PerspectivesDitte S. Kornum0Astrid J. Terkelsen1Davide Bertoli2Mette W. Klinge3Katrine L. Høyer4Huda H. A. Kufaishi5Per Borghammer6Asbjørn M. Drewes7Christina Brock8Klaus Krogh9Department of Hepatology and Gastroenterology, Aarhus University Hospital, DK8200 Aarhus, DenmarkDepartment of Neurology, Aarhus University Hospital, DK8200 Aarhus, DenmarkMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, DK9100 Aalborg, DenmarkDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, DK8200 Aarhus, DenmarkDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, DK8200 Aarhus, DenmarkSteno Diabetes Centre Copenhagen, Gentofte Hospital, DK2820 Gentofte, DenmarkDepartment of Nuclear Medicine and PET-Centre, Aarhus University Hospital, DK8200 Aarhus, DenmarkMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, DK9100 Aalborg, DenmarkMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, DK9100 Aalborg, DenmarkDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, DK8200 Aarhus, DenmarkThe autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson’s disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method.https://www.mdpi.com/2077-0383/10/7/1392autonomic dysfunctiongastrointestinalmotilityinvestigationsmanometrybreath test |
| spellingShingle | Ditte S. Kornum Astrid J. Terkelsen Davide Bertoli Mette W. Klinge Katrine L. Høyer Huda H. A. Kufaishi Per Borghammer Asbjørn M. Drewes Christina Brock Klaus Krogh Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives Journal of Clinical Medicine autonomic dysfunction gastrointestinal motility investigations manometry breath test |
| title | Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives |
| title_full | Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives |
| title_fullStr | Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives |
| title_full_unstemmed | Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives |
| title_short | Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives |
| title_sort | assessment of gastrointestinal autonomic dysfunction present and future perspectives |
| topic | autonomic dysfunction gastrointestinal motility investigations manometry breath test |
| url | https://www.mdpi.com/2077-0383/10/7/1392 |
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