Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel
Polyglycerol dendrimers (PGD) exhibit unique properties such as drug delivery, drug solubilization, bioimaging, and diagnostics. In this study, PGD hydrogels were prepared and evaluated as devices for controlled drug release with good solubilization properties. The PGD hydrogels were prepared by cro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/10/614 |
| _version_ | 1797473185427357696 |
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| author | Tooru Ooya Jaehwi Lee |
| author_facet | Tooru Ooya Jaehwi Lee |
| author_sort | Tooru Ooya |
| collection | DOAJ |
| description | Polyglycerol dendrimers (PGD) exhibit unique properties such as drug delivery, drug solubilization, bioimaging, and diagnostics. In this study, PGD hydrogels were prepared and evaluated as devices for controlled drug release with good solubilization properties. The PGD hydrogels were prepared by crosslinking using ethylene glycol diglycidylether (EGDGE). The concentrations of EGDGE and PGDs were varied. The hydrogels were swellable in ethanol for loading paclitaxel (PTX). The amount of PTX in the hydrogels increased with the swelling ratio, which is proportional to EGDGE/OH ratio, meaning that heterogeneous crosslinking of PGD made high dense region of PGD molecules in the matrix. The hydrogels remained transparent after loading PTX and standing in water for one day, indicating that PTX was dispersed in the hydrogels without any crystallization in water. The results of FTIR imaging of the PTX-loaded PGD hydrogels revealed good dispersion of PTX in the hydrogel matrix. Sixty percent of the loaded PTX was released in a sink condition within 90 min, suggesting that the solubilized PTX would be useful for controlled release without any precipitation. Polyglycerol dendrimer hydrogels are expected to be applicable for rapid release of poorly water-soluble drugs, e.g., for oral administration. |
| first_indexed | 2024-03-09T20:11:16Z |
| format | Article |
| id | doaj.art-0b2e1dd422144c898369b3cabf67491e |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T20:11:16Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-0b2e1dd422144c898369b3cabf67491e2023-11-24T00:13:15ZengMDPI AGGels2310-28612022-09-0181061410.3390/gels8100614Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of PaclitaxelTooru Ooya0Jaehwi Lee1Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, JapanCollege of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, KoreaPolyglycerol dendrimers (PGD) exhibit unique properties such as drug delivery, drug solubilization, bioimaging, and diagnostics. In this study, PGD hydrogels were prepared and evaluated as devices for controlled drug release with good solubilization properties. The PGD hydrogels were prepared by crosslinking using ethylene glycol diglycidylether (EGDGE). The concentrations of EGDGE and PGDs were varied. The hydrogels were swellable in ethanol for loading paclitaxel (PTX). The amount of PTX in the hydrogels increased with the swelling ratio, which is proportional to EGDGE/OH ratio, meaning that heterogeneous crosslinking of PGD made high dense region of PGD molecules in the matrix. The hydrogels remained transparent after loading PTX and standing in water for one day, indicating that PTX was dispersed in the hydrogels without any crystallization in water. The results of FTIR imaging of the PTX-loaded PGD hydrogels revealed good dispersion of PTX in the hydrogel matrix. Sixty percent of the loaded PTX was released in a sink condition within 90 min, suggesting that the solubilized PTX would be useful for controlled release without any precipitation. Polyglycerol dendrimer hydrogels are expected to be applicable for rapid release of poorly water-soluble drugs, e.g., for oral administration.https://www.mdpi.com/2310-2861/8/10/614polyglycerolsdendrimershydrogelspaclitaxelreleasesolubilization |
| spellingShingle | Tooru Ooya Jaehwi Lee Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel Gels polyglycerols dendrimers hydrogels paclitaxel release solubilization |
| title | Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel |
| title_full | Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel |
| title_fullStr | Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel |
| title_full_unstemmed | Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel |
| title_short | Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel |
| title_sort | hydrotropic hydrogels prepared from polyglycerol dendrimers enhanced solubilization and release of paclitaxel |
| topic | polyglycerols dendrimers hydrogels paclitaxel release solubilization |
| url | https://www.mdpi.com/2310-2861/8/10/614 |
| work_keys_str_mv | AT tooruooya hydrotropichydrogelspreparedfrompolyglyceroldendrimersenhancedsolubilizationandreleaseofpaclitaxel AT jaehwilee hydrotropichydrogelspreparedfrompolyglyceroldendrimersenhancedsolubilizationandreleaseofpaclitaxel |