Hepatitis B Virus X Protein Stimulates Hepatitis C Virus (HCV) Replication by Protecting HCV Core Protein from E6AP-Mediated Proteasomal Degradation

Hepatitis B Virus X Protein Stimulates Hepatitis C Virus (HCV) Replication by Protecting HCV Core Protein from E6AP-Mediated Proteasomal Degradation

ABSTRACT Most clinical and experimental studies have suggested that hepatitis C virus (HCV) is dominant over hepatitis B virus (HBV) during coinfection, although the underlying mechanism remains unclear. In this study, we found that the HBV X protein (HBx) upregulates the levels of the HCV core prot...

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Bibliographic Details
Main Authors: Hyunyoung Yoon, Jiwoo Han, Kyung Lib Jang
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
DNA methylation
E6-associated protein
HBx
HCV core protein
ubiquitin-proteasome system
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01432-22

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