Influence of concurrent and functional training on miR-1/miR-126 gene expression and cardiovascular function in postmenopausal women
It is becoming more important to understand the physiological processes that contribute to the emergence of risk factors associated with menopause, and to discover strategies for preventing and reversing them. The current research aimed to determine the impact of functional and concurrent training o...
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| Format: | Article |
| Language: | English |
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JEOCT publisher
2023-12-01
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| Series: | Journal of Exercise & Organ Cross Talk |
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| Online Access: | https://www.jeoct.com/article_186731_c5ed79b46c1b7b719a60384ffdfd3136.pdf |
| _version_ | 1797350578431459328 |
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| author | Majid Kashef Fereshte Shahidi Hadi samadi Leyla Golroo |
| author_facet | Majid Kashef Fereshte Shahidi Hadi samadi Leyla Golroo |
| author_sort | Majid Kashef |
| collection | DOAJ |
| description | It is becoming more important to understand the physiological processes that contribute to the emergence of risk factors associated with menopause, and to discover strategies for preventing and reversing them. The current research aimed to determine the impact of functional and concurrent training on miR-126/miR-1 gene expression, and cardiovascular function in middle-aged postmenopausal women. In this study, 24 women between the ages of 50 and 60 years old with a sedentary life style participated. The subjects were randomly divided into the control group, concurrent training group, and functional training group. The Control received no intervention, and the experimental groups performed selected training protocols for 12 weeks. Doppler ultrasound graphs were utilized after the interventions to evaluate the cardiovascular function. Also, 48 hours after experiment, the blood collection was taken to assess miR-126/miR-1 gene expression. To compare the variables, one-way ANOVA test followed by Tukey's post hoc test was used. The significance level was set at p < 0.05. The results showed that the training programs led to significant enhancements in FLOW-mediated dilation, and PSV (peak systolic velocity). Moreover, there was a significant decrease in the vascular stiffness in the participants after undergoing the training. Additionally, miR-1 and miR-126 gene expression were found to be increased in response to both training interventions. These findings suggest that concurrent and functional training may be an effective approach for reducing the risk of age-related diseases in menopausal women through promoting cardiovascular functions and miR-126/miR-1 gene expression elevation. |
| first_indexed | 2024-03-08T12:47:58Z |
| format | Article |
| id | doaj.art-0b2e7b41b8e64240b6d966cf878f3245 |
| institution | Directory Open Access Journal |
| issn | 2783-2074 |
| language | English |
| last_indexed | 2024-03-08T12:47:58Z |
| publishDate | 2023-12-01 |
| publisher | JEOCT publisher |
| record_format | Article |
| series | Journal of Exercise & Organ Cross Talk |
| spelling | doaj.art-0b2e7b41b8e64240b6d966cf878f32452024-01-20T18:27:14ZengJEOCT publisherJournal of Exercise & Organ Cross Talk2783-20742023-12-013419120010.22122/jeoct.2024.432784.1103186731Influence of concurrent and functional training on miR-1/miR-126 gene expression and cardiovascular function in postmenopausal womenMajid Kashef0Fereshte Shahidi1Hadi samadi2Leyla Golroo3Professor at Exercise Physiology, Exercise Physiology Department, Sport Sciences Faculty, Shahid Rajaee Teacher Training University, Tehran, Iran.Associate Professor at Exercise Physiology, Exercise Physiology Department, Sport Sciences Faculty, Shahid Rajaee Teacher Training University, Tehran, Iran.Assistant Professor at Exercise Physiology, Exercise Physiology Department, Sport Sciences Faculty, Shahid Rajaee Teacher Training University, Tehran, Iran.Ph.D. candidate at Exercise Physiology, Exercise Physiology Department, Sport Sciences Faculty, Shahid Rajaee Teacher Training University, Tehran, IranIt is becoming more important to understand the physiological processes that contribute to the emergence of risk factors associated with menopause, and to discover strategies for preventing and reversing them. The current research aimed to determine the impact of functional and concurrent training on miR-126/miR-1 gene expression, and cardiovascular function in middle-aged postmenopausal women. In this study, 24 women between the ages of 50 and 60 years old with a sedentary life style participated. The subjects were randomly divided into the control group, concurrent training group, and functional training group. The Control received no intervention, and the experimental groups performed selected training protocols for 12 weeks. Doppler ultrasound graphs were utilized after the interventions to evaluate the cardiovascular function. Also, 48 hours after experiment, the blood collection was taken to assess miR-126/miR-1 gene expression. To compare the variables, one-way ANOVA test followed by Tukey's post hoc test was used. The significance level was set at p < 0.05. The results showed that the training programs led to significant enhancements in FLOW-mediated dilation, and PSV (peak systolic velocity). Moreover, there was a significant decrease in the vascular stiffness in the participants after undergoing the training. Additionally, miR-1 and miR-126 gene expression were found to be increased in response to both training interventions. These findings suggest that concurrent and functional training may be an effective approach for reducing the risk of age-related diseases in menopausal women through promoting cardiovascular functions and miR-126/miR-1 gene expression elevation.https://www.jeoct.com/article_186731_c5ed79b46c1b7b719a60384ffdfd3136.pdfmenopausemicrornasstiffness indexpsv |
| spellingShingle | Majid Kashef Fereshte Shahidi Hadi samadi Leyla Golroo Influence of concurrent and functional training on miR-1/miR-126 gene expression and cardiovascular function in postmenopausal women Journal of Exercise & Organ Cross Talk menopause micrornas stiffness index psv |
| title | Influence of concurrent and functional training on miR-1/miR-126 gene expression and cardiovascular function in postmenopausal women |
| title_full | Influence of concurrent and functional training on miR-1/miR-126 gene expression and cardiovascular function in postmenopausal women |
| title_fullStr | Influence of concurrent and functional training on miR-1/miR-126 gene expression and cardiovascular function in postmenopausal women |
| title_full_unstemmed | Influence of concurrent and functional training on miR-1/miR-126 gene expression and cardiovascular function in postmenopausal women |
| title_short | Influence of concurrent and functional training on miR-1/miR-126 gene expression and cardiovascular function in postmenopausal women |
| title_sort | influence of concurrent and functional training on mir 1 mir 126 gene expression and cardiovascular function in postmenopausal women |
| topic | menopause micrornas stiffness index psv |
| url | https://www.jeoct.com/article_186731_c5ed79b46c1b7b719a60384ffdfd3136.pdf |
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