The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.
Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (G...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Journal of Ginseng Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1226845322001208 |
| _version_ | 1828001742415986688 |
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| author | Qi-rui Hu Yao Pan Han-cheng Wu Zhen-zhen Dai Qing-xin Huang Ting Luo Jing Li Ze-yuan Deng Fang Chen |
| author_facet | Qi-rui Hu Yao Pan Han-cheng Wu Zhen-zhen Dai Qing-xin Huang Ting Luo Jing Li Ze-yuan Deng Fang Chen |
| author_sort | Qi-rui Hu |
| collection | DOAJ |
| description | Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion, and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeutics to enhance the anticancer effect and reverse the adverse effects. Here we summarized the understanding of the molecular mechanisms underlying the anticancer effects of GRh2 and proposed future directions to promote the development and application of GRh2. |
| first_indexed | 2024-04-10T06:33:38Z |
| format | Article |
| id | doaj.art-0b2f7bca19d04845b020b466a8ef3f63 |
| institution | Directory Open Access Journal |
| issn | 1226-8453 |
| language | English |
| last_indexed | 2024-04-10T06:33:38Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ginseng Research |
| spelling | doaj.art-0b2f7bca19d04845b020b466a8ef3f632023-03-01T04:31:12ZengElsevierJournal of Ginseng Research1226-84532023-03-01472173182The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.Qi-rui Hu0Yao Pan1Han-cheng Wu2Zhen-zhen Dai3Qing-xin Huang4Ting Luo5Jing Li6Ze-yuan Deng7Fang Chen8State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, Jiangxi, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, Jiangxi, China; Corresponding author. Fang Chen, Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, Jiangxi, 330006, China.Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion, and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeutics to enhance the anticancer effect and reverse the adverse effects. Here we summarized the understanding of the molecular mechanisms underlying the anticancer effects of GRh2 and proposed future directions to promote the development and application of GRh2.http://www.sciencedirect.com/science/article/pii/S1226845322001208ginsenoside Rh2anticancerapoptosisanti-proliferation |
| spellingShingle | Qi-rui Hu Yao Pan Han-cheng Wu Zhen-zhen Dai Qing-xin Huang Ting Luo Jing Li Ze-yuan Deng Fang Chen The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo. Journal of Ginseng Research ginsenoside Rh2 anticancer apoptosis anti-proliferation |
| title | The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo. |
| title_full | The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo. |
| title_fullStr | The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo. |
| title_full_unstemmed | The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo. |
| title_short | The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo. |
| title_sort | ways for ginsenoside rh2 to fight against cancer the molecular evidences in vitro and in vivo |
| topic | ginsenoside Rh2 anticancer apoptosis anti-proliferation |
| url | http://www.sciencedirect.com/science/article/pii/S1226845322001208 |
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