Molecular mechanisms behind mRNA localization in axons
Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at the subcellular level. This is observed in the axons of neurons, where mRNA localization is involved in regulating neuronal development and function by orchestrating rapid adaptive responses to extracellular cues a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2020-09-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200177 |
| _version_ | 1819114167089496064 |
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| author | Benita Turner-Bridger Cinzia Caterino Jean-Michel Cioni |
| author_facet | Benita Turner-Bridger Cinzia Caterino Jean-Michel Cioni |
| author_sort | Benita Turner-Bridger |
| collection | DOAJ |
| description | Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at the subcellular level. This is observed in the axons of neurons, where mRNA localization is involved in regulating neuronal development and function by orchestrating rapid adaptive responses to extracellular cues and the maintenance of axonal homeostasis through local translation. Here, we provide an overview of the key findings that have broadened our knowledge regarding how specific mRNAs are trafficked and localize to axons. In particular, we review transcriptomic studies investigating mRNA content in axons and the molecular principles underpinning how these mRNAs arrived there, including cis-acting mRNA sequences and trans-acting proteins playing a role. Further, we discuss evidence that links defective axonal mRNA localization and pathological outcomes. |
| first_indexed | 2024-12-22T04:40:59Z |
| format | Article |
| id | doaj.art-0b30189be7944613b2b732bcf8b0ee6d |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-22T04:40:59Z |
| publishDate | 2020-09-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-0b30189be7944613b2b732bcf8b0ee6d2022-12-21T18:38:45ZengThe Royal SocietyOpen Biology2046-24412020-09-0110910.1098/rsob.200177200177Molecular mechanisms behind mRNA localization in axonsBenita Turner-BridgerCinzia CaterinoJean-Michel CioniMessenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at the subcellular level. This is observed in the axons of neurons, where mRNA localization is involved in regulating neuronal development and function by orchestrating rapid adaptive responses to extracellular cues and the maintenance of axonal homeostasis through local translation. Here, we provide an overview of the key findings that have broadened our knowledge regarding how specific mRNAs are trafficked and localize to axons. In particular, we review transcriptomic studies investigating mRNA content in axons and the molecular principles underpinning how these mRNAs arrived there, including cis-acting mRNA sequences and trans-acting proteins playing a role. Further, we discuss evidence that links defective axonal mRNA localization and pathological outcomes.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200177mrna traffickingrna-binding proteinsaxonneuronlocal translation |
| spellingShingle | Benita Turner-Bridger Cinzia Caterino Jean-Michel Cioni Molecular mechanisms behind mRNA localization in axons Open Biology mrna trafficking rna-binding proteins axon neuron local translation |
| title | Molecular mechanisms behind mRNA localization in axons |
| title_full | Molecular mechanisms behind mRNA localization in axons |
| title_fullStr | Molecular mechanisms behind mRNA localization in axons |
| title_full_unstemmed | Molecular mechanisms behind mRNA localization in axons |
| title_short | Molecular mechanisms behind mRNA localization in axons |
| title_sort | molecular mechanisms behind mrna localization in axons |
| topic | mrna trafficking rna-binding proteins axon neuron local translation |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200177 |
| work_keys_str_mv | AT benitaturnerbridger molecularmechanismsbehindmrnalocalizationinaxons AT cinziacaterino molecularmechanismsbehindmrnalocalizationinaxons AT jeanmichelcioni molecularmechanismsbehindmrnalocalizationinaxons |