Clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a Scottish Terrier bitch
ABSTRACT: Hyperphosphatasemia refers to an increase in alkaline phosphatase serum activity, and Scottish Terriers (STs) are predisposed to develop this condition of uncertain pathogenesis. This study describes a case of progressive hyperphosphatasemia with vacuolar hepatopathy and hepatocellular car...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Santa Maria
2022-06-01
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| Series: | Ciência Rural |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000100552&tlng=en |
| _version_ | 1818244376282791936 |
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| author | Paula Reis Ribeiro Matheus Viezzer Bianchi Marina Paula Lorenzett Matheus de Oliveira Reis Alan Gomes Pöppl Saulo Petinatti Pavarini |
| author_facet | Paula Reis Ribeiro Matheus Viezzer Bianchi Marina Paula Lorenzett Matheus de Oliveira Reis Alan Gomes Pöppl Saulo Petinatti Pavarini |
| author_sort | Paula Reis Ribeiro |
| collection | DOAJ |
| description | ABSTRACT: Hyperphosphatasemia refers to an increase in alkaline phosphatase serum activity, and Scottish Terriers (STs) are predisposed to develop this condition of uncertain pathogenesis. This study describes a case of progressive hyperphosphatasemia with vacuolar hepatopathy and hepatocellular carcinoma (HCC) in a ST bitch. This dog had a five-year clinical follow-up with progressive hyperphosphatasemia (up to 5503 U/L) and with ultrasound findings and histologic diagnosis of vacuolar hepatopathy, in addition to posterior onset of HCC. A steroidogenic adrenal panel revealed an increase of adrenocortical hormones, especially progesterone and androstenedione, consistent with a subdiagnosed hypercortisolism. Euthanasia was elected and at necropsy, multinodular, yellow to red masses were observed in the liver, which were histologically and immunohistochemically defined as HCC. The association of the clinical, imaging, biochemical, adrenal panel and pathologic findings allowed to characterize and confirm a progressive disorder in this ST bitch associated with elevated adrenocortical hormones. |
| first_indexed | 2024-12-12T14:16:02Z |
| format | Article |
| id | doaj.art-0b311d77893840c194c453feac85d074 |
| institution | Directory Open Access Journal |
| issn | 1678-4596 |
| language | English |
| last_indexed | 2024-12-12T14:16:02Z |
| publishDate | 2022-06-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj.art-0b311d77893840c194c453feac85d0742022-12-22T00:21:54ZengUniversidade Federal de Santa MariaCiência Rural1678-45962022-06-0153110.1590/0103-8478cr20210689Clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a Scottish Terrier bitchPaula Reis Ribeirohttps://orcid.org/0000-0003-3530-3151Matheus Viezzer Bianchihttps://orcid.org/0000-0002-3951-0038Marina Paula Lorenzetthttps://orcid.org/0000-0002-9551-3399Matheus de Oliveira Reishttps://orcid.org/0000-0002-9592-178XAlan Gomes Pöpplhttps://orcid.org/0000-0002-7117-5284Saulo Petinatti Pavarinihttps://orcid.org/0000-0001-8980-6294ABSTRACT: Hyperphosphatasemia refers to an increase in alkaline phosphatase serum activity, and Scottish Terriers (STs) are predisposed to develop this condition of uncertain pathogenesis. This study describes a case of progressive hyperphosphatasemia with vacuolar hepatopathy and hepatocellular carcinoma (HCC) in a ST bitch. This dog had a five-year clinical follow-up with progressive hyperphosphatasemia (up to 5503 U/L) and with ultrasound findings and histologic diagnosis of vacuolar hepatopathy, in addition to posterior onset of HCC. A steroidogenic adrenal panel revealed an increase of adrenocortical hormones, especially progesterone and androstenedione, consistent with a subdiagnosed hypercortisolism. Euthanasia was elected and at necropsy, multinodular, yellow to red masses were observed in the liver, which were histologically and immunohistochemically defined as HCC. The association of the clinical, imaging, biochemical, adrenal panel and pathologic findings allowed to characterize and confirm a progressive disorder in this ST bitch associated with elevated adrenocortical hormones.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000100552&tlng=enadrenocortical hormonesalkaline phosphatasedogliverneoplasm |
| spellingShingle | Paula Reis Ribeiro Matheus Viezzer Bianchi Marina Paula Lorenzett Matheus de Oliveira Reis Alan Gomes Pöppl Saulo Petinatti Pavarini Clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a Scottish Terrier bitch Ciência Rural adrenocortical hormones alkaline phosphatase dog liver neoplasm |
| title | Clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a Scottish Terrier bitch |
| title_full | Clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a Scottish Terrier bitch |
| title_fullStr | Clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a Scottish Terrier bitch |
| title_full_unstemmed | Clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a Scottish Terrier bitch |
| title_short | Clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a Scottish Terrier bitch |
| title_sort | clinical and pathological aspects of progressive hyperphosphatasemia associated with vacuolar hepatopathy and hepatocellular carcinoma in a scottish terrier bitch |
| topic | adrenocortical hormones alkaline phosphatase dog liver neoplasm |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000100552&tlng=en |
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