Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants
Since the beginning of the 2021 year, all the main six vaccines against COVID-19 have been used in mass vaccination companies around the world. Virus neutralization and epidemiological efficacy drop obtained for several vaccines against the B.1.1.7, B.1.351 P.1, and B.1.617 genotypes are of concern....
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/7/779 |
| _version_ | 1797525890840657920 |
|---|---|
| author | Vladimir A. Gushchin Inna V. Dolzhikova Alexey M. Shchetinin Alina S. Odintsova Andrei E. Siniavin Maria A. Nikiforova Andrei A. Pochtovyi Elena V. Shidlovskaya Nadezhda A. Kuznetsova Olga A. Burgasova Liudmila V. Kolobukhina Anna A. Iliukhina Anna V. Kovyrshina Andrey G. Botikov Aleksandra V. Kuzina Daria M. Grousova Amir I. Tukhvatulin Dmitry V. Shcheblyakov Olga V. Zubkova Oksana V. Karpova Olga L. Voronina Natalia N. Ryzhova Ekaterina I. Aksenova Marina S. Kunda Dmitry A. Lioznov Daria M. Danilenko Andrey B. Komissarov Artem P. Tkachuck Denis Y. Logunov Alexander L. Gintsburg |
| author_facet | Vladimir A. Gushchin Inna V. Dolzhikova Alexey M. Shchetinin Alina S. Odintsova Andrei E. Siniavin Maria A. Nikiforova Andrei A. Pochtovyi Elena V. Shidlovskaya Nadezhda A. Kuznetsova Olga A. Burgasova Liudmila V. Kolobukhina Anna A. Iliukhina Anna V. Kovyrshina Andrey G. Botikov Aleksandra V. Kuzina Daria M. Grousova Amir I. Tukhvatulin Dmitry V. Shcheblyakov Olga V. Zubkova Oksana V. Karpova Olga L. Voronina Natalia N. Ryzhova Ekaterina I. Aksenova Marina S. Kunda Dmitry A. Lioznov Daria M. Danilenko Andrey B. Komissarov Artem P. Tkachuck Denis Y. Logunov Alexander L. Gintsburg |
| author_sort | Vladimir A. Gushchin |
| collection | DOAJ |
| description | Since the beginning of the 2021 year, all the main six vaccines against COVID-19 have been used in mass vaccination companies around the world. Virus neutralization and epidemiological efficacy drop obtained for several vaccines against the B.1.1.7, B.1.351 P.1, and B.1.617 genotypes are of concern. There is a growing number of reports on mutations in receptor-binding domain (RBD) increasing the transmissibility of the virus and escaping the neutralizing effect of antibodies. The Sputnik V vaccine is currently approved for use in more than 66 countries but its activity against variants of concern (VOC) is not extensively studied yet. Virus-neutralizing activity (VNA) of sera obtained from people vaccinated with Sputnik V in relation to internationally relevant genetic lineages B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3 and Moscow endemic variants B.1.1.141 (T385I) and B.1.1.317 (S477N, A522S) with mutations in the RBD domain has been assessed. The data obtained indicate no significant differences in VNA against B.1.1.7, B.1.617.3 and local genetic lineages B.1.1.141 (T385I), B.1.1.317 (S477N, A522S) with RBD mutations. For the B.1.351, P.1, and B.1.617.2 statistically significant 3.1-, 2.8-, and 2.5-fold, respectively, VNA reduction was observed. Notably, this decrease is lower than that reported in publications for other vaccines. However, a direct comparative study is necessary for a conclusion. Thus, sera from “Sputnik V”-vaccinated retain neutralizing activity against VOC B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3 as well as local genetic lineages B.1.1.141 and B.1.1.317 circulating in Moscow. |
| first_indexed | 2024-03-10T09:20:25Z |
| format | Article |
| id | doaj.art-0b31c283f51e46aabe29d31600c5e309 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T09:20:25Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-0b31c283f51e46aabe29d31600c5e3092023-11-22T05:12:55ZengMDPI AGVaccines2076-393X2021-07-019777910.3390/vaccines9070779Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 VariantsVladimir A. Gushchin0Inna V. Dolzhikova1Alexey M. Shchetinin2Alina S. Odintsova3Andrei E. Siniavin4Maria A. Nikiforova5Andrei A. Pochtovyi6Elena V. Shidlovskaya7Nadezhda A. Kuznetsova8Olga A. Burgasova9Liudmila V. Kolobukhina10Anna A. Iliukhina11Anna V. Kovyrshina12Andrey G. Botikov13Aleksandra V. Kuzina14Daria M. Grousova15Amir I. Tukhvatulin16Dmitry V. Shcheblyakov17Olga V. Zubkova18Oksana V. Karpova19Olga L. Voronina20Natalia N. Ryzhova21Ekaterina I. Aksenova22Marina S. Kunda23Dmitry A. Lioznov24Daria M. Danilenko25Andrey B. Komissarov26Artem P. Tkachuck27Denis Y. Logunov28Alexander L. Gintsburg29Federal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaMoscow Healthcare Department, 127006 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaSmorodintsev Research Institute of Influenza, 197022 St. Petersburg, RussiaSmorodintsev Research Institute of Influenza, 197022 St. Petersburg, RussiaSmorodintsev Research Institute of Influenza, 197022 St. Petersburg, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFederal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaSince the beginning of the 2021 year, all the main six vaccines against COVID-19 have been used in mass vaccination companies around the world. Virus neutralization and epidemiological efficacy drop obtained for several vaccines against the B.1.1.7, B.1.351 P.1, and B.1.617 genotypes are of concern. There is a growing number of reports on mutations in receptor-binding domain (RBD) increasing the transmissibility of the virus and escaping the neutralizing effect of antibodies. The Sputnik V vaccine is currently approved for use in more than 66 countries but its activity against variants of concern (VOC) is not extensively studied yet. Virus-neutralizing activity (VNA) of sera obtained from people vaccinated with Sputnik V in relation to internationally relevant genetic lineages B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3 and Moscow endemic variants B.1.1.141 (T385I) and B.1.1.317 (S477N, A522S) with mutations in the RBD domain has been assessed. The data obtained indicate no significant differences in VNA against B.1.1.7, B.1.617.3 and local genetic lineages B.1.1.141 (T385I), B.1.1.317 (S477N, A522S) with RBD mutations. For the B.1.351, P.1, and B.1.617.2 statistically significant 3.1-, 2.8-, and 2.5-fold, respectively, VNA reduction was observed. Notably, this decrease is lower than that reported in publications for other vaccines. However, a direct comparative study is necessary for a conclusion. Thus, sera from “Sputnik V”-vaccinated retain neutralizing activity against VOC B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3 as well as local genetic lineages B.1.1.141 and B.1.1.317 circulating in Moscow.https://www.mdpi.com/2076-393X/9/7/779COVID-19SARS-CoV-2vaccineSputnik VVOCvirus neutralizing activity |
| spellingShingle | Vladimir A. Gushchin Inna V. Dolzhikova Alexey M. Shchetinin Alina S. Odintsova Andrei E. Siniavin Maria A. Nikiforova Andrei A. Pochtovyi Elena V. Shidlovskaya Nadezhda A. Kuznetsova Olga A. Burgasova Liudmila V. Kolobukhina Anna A. Iliukhina Anna V. Kovyrshina Andrey G. Botikov Aleksandra V. Kuzina Daria M. Grousova Amir I. Tukhvatulin Dmitry V. Shcheblyakov Olga V. Zubkova Oksana V. Karpova Olga L. Voronina Natalia N. Ryzhova Ekaterina I. Aksenova Marina S. Kunda Dmitry A. Lioznov Daria M. Danilenko Andrey B. Komissarov Artem P. Tkachuck Denis Y. Logunov Alexander L. Gintsburg Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants Vaccines COVID-19 SARS-CoV-2 vaccine Sputnik V VOC virus neutralizing activity |
| title | Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants |
| title_full | Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants |
| title_fullStr | Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants |
| title_full_unstemmed | Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants |
| title_short | Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants |
| title_sort | neutralizing activity of sera from sputnik v vaccinated people against variants of concern voc b 1 1 7 b 1 351 p 1 b 1 617 2 b 1 617 3 and moscow endemic sars cov 2 variants |
| topic | COVID-19 SARS-CoV-2 vaccine Sputnik V VOC virus neutralizing activity |
| url | https://www.mdpi.com/2076-393X/9/7/779 |
| work_keys_str_mv | AT vladimiragushchin neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT innavdolzhikova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT alexeymshchetinin neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT alinasodintsova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT andreiesiniavin neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT mariaanikiforova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT andreiapochtovyi neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT elenavshidlovskaya neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT nadezhdaakuznetsova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT olgaaburgasova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT liudmilavkolobukhina neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT annaailiukhina neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT annavkovyrshina neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT andreygbotikov neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT aleksandravkuzina neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT dariamgrousova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT amiritukhvatulin neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT dmitryvshcheblyakov neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT olgavzubkova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT oksanavkarpova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT olgalvoronina neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT natalianryzhova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT ekaterinaiaksenova neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT marinaskunda neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT dmitryalioznov neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT dariamdanilenko neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT andreybkomissarov neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT artemptkachuck neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT denisylogunov neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants AT alexanderlgintsburg neutralizingactivityofserafromsputnikvvaccinatedpeopleagainstvariantsofconcernvocb117b1351p1b16172b16173andmoscowendemicsarscov2variants |