Risk factors for the first and second inappropriate implantable cardioverter-defibrillator therapy
Introduction: Various risk factors for the first inappropriate implantable cardioverter-defibrillator (ICD) therapy event have been reported, including a history of atrial fibrillation/atrial flutter (AF/AFL), younger age, and multiple zones. Nonetheless, which factors are concordant with real-world...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906721000671 |
| _version_ | 1823928789993783296 |
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| author | Nobuhiro Nishii Takashi Noda Takashi Nitta Yoshifusa Aizawa Tohru Ohe Takashi Kurita |
| author_facet | Nobuhiro Nishii Takashi Noda Takashi Nitta Yoshifusa Aizawa Tohru Ohe Takashi Kurita |
| author_sort | Nobuhiro Nishii |
| collection | DOAJ |
| description | Introduction: Various risk factors for the first inappropriate implantable cardioverter-defibrillator (ICD) therapy event have been reported, including a history of atrial fibrillation/atrial flutter (AF/AFL), younger age, and multiple zones. Nonetheless, which factors are concordant with real-world data has not been clarified, and risk factors for the second inappropriate ICD therapy event have not been well examined. This study aimed to clarify the risk factors for the first and second inappropriate ICD therapy events. Methods: We conducted a post-hoc secondary analysis of data from a multicenter, prospective observational study (the Nippon Storm Study) designed to clarify the risk factors for electrical storm. Results: The analysis included data from 1549 patients who received ICD or cardiac resynchronization therapy with defibrillator (CRT-D). Over a median follow-up of 28 months, 293 inappropriate ICD therapy events occurred in 153 (10.0%) patients. On multivariate Cox regression analysis, the risk factors for the first inappropriate ICD therapy event were younger age (hazard ratio [HR], 0.986; p = 0.028), AF/AFL (HR, 2.324; p = 0.002), ICD without CRT implantation (HR, 2.377; p = 0.004), and multiple zones (HR, 1.852; p = 0.010). “No-intervention” after the first inappropriate ICD therapy event was the sole risk factor for the second inappropriate ICD therapy event. Conclusions: Risk factors for the first inappropriate ICD therapy event were similar to those previously reported. Immediate intervention after the first inappropriate ICD therapy event could reduce the risk of the second inappropriate event. |
| first_indexed | 2024-12-16T20:59:44Z |
| format | Article |
| id | doaj.art-0b32aa433b884a5281bae561f70b2049 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-16T20:59:44Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-0b32aa433b884a5281bae561f70b20492022-12-21T22:16:31ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672021-06-0134100779Risk factors for the first and second inappropriate implantable cardioverter-defibrillator therapyNobuhiro Nishii0Takashi Noda1Takashi Nitta2Yoshifusa Aizawa3Tohru Ohe4Takashi Kurita5Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan; Corresponding author at: Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, JapanDepartment of Cardiovascular Surgery, Nippon Medical School, Tokyo, JapanDepartment of Research and Development, Tachikawa Medical Center, Niigata, JapanOkayama City Hospital, Okayama, JapanDepartment of Internal Medicine, Faculty of Medicine, Kindai University, Osaka-Sayama, JapanIntroduction: Various risk factors for the first inappropriate implantable cardioverter-defibrillator (ICD) therapy event have been reported, including a history of atrial fibrillation/atrial flutter (AF/AFL), younger age, and multiple zones. Nonetheless, which factors are concordant with real-world data has not been clarified, and risk factors for the second inappropriate ICD therapy event have not been well examined. This study aimed to clarify the risk factors for the first and second inappropriate ICD therapy events. Methods: We conducted a post-hoc secondary analysis of data from a multicenter, prospective observational study (the Nippon Storm Study) designed to clarify the risk factors for electrical storm. Results: The analysis included data from 1549 patients who received ICD or cardiac resynchronization therapy with defibrillator (CRT-D). Over a median follow-up of 28 months, 293 inappropriate ICD therapy events occurred in 153 (10.0%) patients. On multivariate Cox regression analysis, the risk factors for the first inappropriate ICD therapy event were younger age (hazard ratio [HR], 0.986; p = 0.028), AF/AFL (HR, 2.324; p = 0.002), ICD without CRT implantation (HR, 2.377; p = 0.004), and multiple zones (HR, 1.852; p = 0.010). “No-intervention” after the first inappropriate ICD therapy event was the sole risk factor for the second inappropriate ICD therapy event. Conclusions: Risk factors for the first inappropriate ICD therapy event were similar to those previously reported. Immediate intervention after the first inappropriate ICD therapy event could reduce the risk of the second inappropriate event.http://www.sciencedirect.com/science/article/pii/S2352906721000671Nippon storm studyImplantable cardioverter-defibrillatorCardiac resynchronization therapy with defibrillatorInappropriate ICD therapy |
| spellingShingle | Nobuhiro Nishii Takashi Noda Takashi Nitta Yoshifusa Aizawa Tohru Ohe Takashi Kurita Risk factors for the first and second inappropriate implantable cardioverter-defibrillator therapy International Journal of Cardiology: Heart & Vasculature Nippon storm study Implantable cardioverter-defibrillator Cardiac resynchronization therapy with defibrillator Inappropriate ICD therapy |
| title | Risk factors for the first and second inappropriate implantable cardioverter-defibrillator therapy |
| title_full | Risk factors for the first and second inappropriate implantable cardioverter-defibrillator therapy |
| title_fullStr | Risk factors for the first and second inappropriate implantable cardioverter-defibrillator therapy |
| title_full_unstemmed | Risk factors for the first and second inappropriate implantable cardioverter-defibrillator therapy |
| title_short | Risk factors for the first and second inappropriate implantable cardioverter-defibrillator therapy |
| title_sort | risk factors for the first and second inappropriate implantable cardioverter defibrillator therapy |
| topic | Nippon storm study Implantable cardioverter-defibrillator Cardiac resynchronization therapy with defibrillator Inappropriate ICD therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2352906721000671 |
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