Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup"
The purpose of the research is conducting pharmaco-toxicological assessment of Gelmintal Mini Syrup based on a combination of moxidectin and toltrazuril. Materials and methods. The study was carried out on 64 white male rats and 40 white mice. Each animal species was divided into 4 equivalent groups...
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| Format: | Article |
| Language: | Russian |
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Federal Scientific Centre VIEV
2020-10-01
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| Series: | Российский паразитологический журнал |
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| Online Access: | https://vniigis.elpub.ru/jour/article/view/667 |
| _version_ | 1826569969950785536 |
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| author | G. B. Arisova M. V. Arisov I. A. Stepanova V. V. Khristenko |
| author_facet | G. B. Arisova M. V. Arisov I. A. Stepanova V. V. Khristenko |
| author_sort | G. B. Arisova |
| collection | DOAJ |
| description | The purpose of the research is conducting pharmaco-toxicological assessment of Gelmintal Mini Syrup based on a combination of moxidectin and toltrazuril. Materials and methods. The study was carried out on 64 white male rats and 40 white mice. Each animal species was divided into 4 equivalent groups of 6–10 animals each. When studying acute toxicity, the drug was administered in the form of a syrup (without dilution) to animals once at doses of 11 400, 22 800 and 28 500 mg/kg; when studying subchronic toxicity, the drug was administered daily for 14 days at doses of 570, 1425 and 2850 mg/kg (1/10 and 1/20 and 1/50 of the maximum possible dose administered into the stomach according to the vivisection results). When studying acute toxicity, the animals were followed up for 14 days; we recorded the general condition and behavior of the animals, changes in their body weight, the manifestation of toxic symptoms or possible death. When studying subchronic toxicity, the animals were followed up during the entire period of the drug use (14 days); on the 15th and 24th days of the experiment, we performed euthanasia, collected the blood to determine hematological and biochemical values, and carried out macroscopic examination of the organs. Results and discussion. We did not record the animals’ death at doses of 11 400, 22 800 and 28 500 mg/kg; and no signs of intoxication were noted for the entire follow-up period. LD50 of Gelmintal Mini Syrup exceeds the dose of 28500 mg/kg, i.e. the drug is classified as the 4th hazard class. The results of the studied subchronic toxicity showed that the drug was inactive at doses of 570 mg/kg, 1425 and 2850 mg/kg when administered orally for 14 days. |
| first_indexed | 2024-03-08T21:40:43Z |
| format | Article |
| id | doaj.art-0b383ad4154c433e86da5a341d538c44 |
| institution | Directory Open Access Journal |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| last_indexed | 2025-03-14T11:47:47Z |
| publishDate | 2020-10-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj.art-0b383ad4154c433e86da5a341d538c442025-03-02T09:49:58ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432020-10-01143909810.31016/1998-8435-2020-14-3-90-98599Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup"G. B. Arisova0M. V. Arisov1I. A. Stepanova2V. V. Khristenko3All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”Russian State Center for Quality and Standardization of Animal Drugs and FeedThe purpose of the research is conducting pharmaco-toxicological assessment of Gelmintal Mini Syrup based on a combination of moxidectin and toltrazuril. Materials and methods. The study was carried out on 64 white male rats and 40 white mice. Each animal species was divided into 4 equivalent groups of 6–10 animals each. When studying acute toxicity, the drug was administered in the form of a syrup (without dilution) to animals once at doses of 11 400, 22 800 and 28 500 mg/kg; when studying subchronic toxicity, the drug was administered daily for 14 days at doses of 570, 1425 and 2850 mg/kg (1/10 and 1/20 and 1/50 of the maximum possible dose administered into the stomach according to the vivisection results). When studying acute toxicity, the animals were followed up for 14 days; we recorded the general condition and behavior of the animals, changes in their body weight, the manifestation of toxic symptoms or possible death. When studying subchronic toxicity, the animals were followed up during the entire period of the drug use (14 days); on the 15th and 24th days of the experiment, we performed euthanasia, collected the blood to determine hematological and biochemical values, and carried out macroscopic examination of the organs. Results and discussion. We did not record the animals’ death at doses of 11 400, 22 800 and 28 500 mg/kg; and no signs of intoxication were noted for the entire follow-up period. LD50 of Gelmintal Mini Syrup exceeds the dose of 28500 mg/kg, i.e. the drug is classified as the 4th hazard class. The results of the studied subchronic toxicity showed that the drug was inactive at doses of 570 mg/kg, 1425 and 2850 mg/kg when administered orally for 14 days.https://vniigis.elpub.ru/jour/article/view/667"gelmintal mini syrup"toltrazurilmoxidectinacute toxicitysubchronic toxicitywhite ratswhite mice |
| spellingShingle | G. B. Arisova M. V. Arisov I. A. Stepanova V. V. Khristenko Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup" Российский паразитологический журнал "gelmintal mini syrup" toltrazuril moxidectin acute toxicity subchronic toxicity white rats white mice |
| title | Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup" |
| title_full | Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup" |
| title_fullStr | Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup" |
| title_full_unstemmed | Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup" |
| title_short | Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup" |
| title_sort | pharmaco toxicological assessment of antiparasitic drug for dogs and cats gelmintal mini syrup |
| topic | "gelmintal mini syrup" toltrazuril moxidectin acute toxicity subchronic toxicity white rats white mice |
| url | https://vniigis.elpub.ru/jour/article/view/667 |
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