Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat model

Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat model

Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with a poor prognosis. There is currently no definitive cure for IPF. The present study establishes a platform for the development of a novel therapeutic approach for the treatment of PF using the atypical antidepress...

Full description

Bibliographic Details
Main Authors: Rasha Abdelhady, Simona Cavalu, Sameh Saber, Rasha Elmowafy, Nesreen Elsayed Morsy, Samar Ibrahim, Mahmoud Said Ibrahim Abdeldaiem, Mervat Samy, Marwa A. Abd-Eldayem, Ahmed Shata, Rehab Mohamed Elgharabawy
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Mirtazapine
Pulmonary fibrosis
Bleomycin
NLRP3 inflammasome
TGF-β, IL-1β
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223003414

Similar Items

Similar Items