Recent Advances in the Treatment of Ocular Complications of Rheumatoid Arthritis: A review of current literature
Introduction: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that often causes ocular complications, of which keratoconjunctivitis sicca (KCS), scleritis and episcleritis are the most common entities. When left untreated, they can adversely affect eye health and cause vision loss in...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2024-02-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/48109 |
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| author | Olgerd Duchnevič Iwona Galasińska Beniamin Michalik Katarzyna Hajduk-Maślak Aleksandra Szypuła Michał Sęk Adrianna Skóra |
| author_facet | Olgerd Duchnevič Iwona Galasińska Beniamin Michalik Katarzyna Hajduk-Maślak Aleksandra Szypuła Michał Sęk Adrianna Skóra |
| author_sort | Olgerd Duchnevič |
| collection | DOAJ |
| description | Introduction: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that often causes ocular complications, of which keratoconjunctivitis sicca (KCS), scleritis and episcleritis are the most common entities. When left untreated, they can adversely affect eye health and cause vision loss in severe cases. Therefore, early and effective treatment of ophthalmic complications may significantly improve visual outcomes in patients with rheumatoid arthritis.
Aim of the study: The aim of the study was to compile and analyze the current literature on the treatment of the most prevalent ocular manifestation associated with RA. Special emphasis was placed on recently approved drugs and those in late-stage clinical trials.
Methods and materials: Publication research was conducted using the PubMed database and Google Scholar with a primary focus on literature from the past 10 years. Firstly, common ocular complications of rheumatoid arthritis were identified and relevant treatment modalities were extracted for further analysis. Finally, the names of relevant drugs or drug classes were used along with the names of the aforementioned disease entities to discover clinical trials regarding their efficacy and safety. Additionally, references from selected manuscripts were included.
Summary: The landscape of treatment for ocular complications associated with RA offers a promising future for patients and clinicians. Three new therapeutic modalities for dry eye disease have been approved in 2023, and three additional drugs are in late-stage clinical trials. Furthermore, recent advances in biologic therapy have shown considerable promise in treating scleritis, especially in patients refractory to conventional treatment or with severe symptoms of the disease.
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| first_indexed | 2024-03-07T23:54:34Z |
| format | Article |
| id | doaj.art-0b3ac007c25145259ca0ef254dac6c57 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-03-07T23:54:34Z |
| publishDate | 2024-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-0b3ac007c25145259ca0ef254dac6c572024-02-18T11:53:03ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062024-02-015910.12775/JEHS.2024.59.007Recent Advances in the Treatment of Ocular Complications of Rheumatoid Arthritis: A review of current literatureOlgerd Duchnevič0Iwona Galasińska1Beniamin Michalik2Katarzyna Hajduk-Maślak3Aleksandra Szypuła4Michał Sęk5Adrianna Skóra6Ludwik Rydygier Memorial Hospital in CracowIndependent Public Healthcare Centre in Proszowice, ul. Mikołaja Kopernika 13, 32-100 ProszowiceNZOZ SANA-MED, Osiedle Dywizjonu 303 2, 31-871 KrakówLUX MED Sp. z o.o., ul. Opolska 110, 31-355 KrakówCM Medycyna Rodzinna General Practice Center, Frycza-Modrzewskiego 2, 31-216 KrakówJagiellonian University Medical College, ul. św. Anny 12, 31-008 KrakówIndependent Public Health Care Facility in Myslenice, ul. Szpitalna 2, 32-400 MyśleniceIntroduction: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that often causes ocular complications, of which keratoconjunctivitis sicca (KCS), scleritis and episcleritis are the most common entities. When left untreated, they can adversely affect eye health and cause vision loss in severe cases. Therefore, early and effective treatment of ophthalmic complications may significantly improve visual outcomes in patients with rheumatoid arthritis. Aim of the study: The aim of the study was to compile and analyze the current literature on the treatment of the most prevalent ocular manifestation associated with RA. Special emphasis was placed on recently approved drugs and those in late-stage clinical trials. Methods and materials: Publication research was conducted using the PubMed database and Google Scholar with a primary focus on literature from the past 10 years. Firstly, common ocular complications of rheumatoid arthritis were identified and relevant treatment modalities were extracted for further analysis. Finally, the names of relevant drugs or drug classes were used along with the names of the aforementioned disease entities to discover clinical trials regarding their efficacy and safety. Additionally, references from selected manuscripts were included. Summary: The landscape of treatment for ocular complications associated with RA offers a promising future for patients and clinicians. Three new therapeutic modalities for dry eye disease have been approved in 2023, and three additional drugs are in late-stage clinical trials. Furthermore, recent advances in biologic therapy have shown considerable promise in treating scleritis, especially in patients refractory to conventional treatment or with severe symptoms of the disease. https://apcz.umk.pl/JEHS/article/view/48109rheumatoid arthritisscleritisepiscleritisocular inflammationdry eye syndromekeratoconjunctivitis sicca |
| spellingShingle | Olgerd Duchnevič Iwona Galasińska Beniamin Michalik Katarzyna Hajduk-Maślak Aleksandra Szypuła Michał Sęk Adrianna Skóra Recent Advances in the Treatment of Ocular Complications of Rheumatoid Arthritis: A review of current literature Journal of Education, Health and Sport rheumatoid arthritis scleritis episcleritis ocular inflammation dry eye syndrome keratoconjunctivitis sicca |
| title | Recent Advances in the Treatment of Ocular Complications of Rheumatoid Arthritis: A review of current literature |
| title_full | Recent Advances in the Treatment of Ocular Complications of Rheumatoid Arthritis: A review of current literature |
| title_fullStr | Recent Advances in the Treatment of Ocular Complications of Rheumatoid Arthritis: A review of current literature |
| title_full_unstemmed | Recent Advances in the Treatment of Ocular Complications of Rheumatoid Arthritis: A review of current literature |
| title_short | Recent Advances in the Treatment of Ocular Complications of Rheumatoid Arthritis: A review of current literature |
| title_sort | recent advances in the treatment of ocular complications of rheumatoid arthritis a review of current literature |
| topic | rheumatoid arthritis scleritis episcleritis ocular inflammation dry eye syndrome keratoconjunctivitis sicca |
| url | https://apcz.umk.pl/JEHS/article/view/48109 |
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