Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature
Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/2/156 |
| _version_ | 1811187302137856000 |
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| author | Ana Zugic Vanja Tadic Snezana Savic |
| author_facet | Ana Zugic Vanja Tadic Snezana Savic |
| author_sort | Ana Zugic |
| collection | DOAJ |
| description | Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano- and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro- and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug. |
| first_indexed | 2024-04-11T14:01:05Z |
| format | Article |
| id | doaj.art-0b3b2ac9abc24577bf5c0c79602f7ebb |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T14:01:05Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-0b3b2ac9abc24577bf5c0c79602f7ebb2022-12-22T04:20:08ZengMDPI AGPharmaceutics1999-49232020-02-0112215610.3390/pharmaceutics12020156pharmaceutics12020156Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of LiteratureAna Zugic0Vanja Tadic1Snezana Savic2Institute for Medicinal Plant Research “Dr. Josif Pancic”, Tadeusa Koscuska 1, 11000 Belgrade, SerbiaInstitute for Medicinal Plant Research “Dr. Josif Pancic”, Tadeusa Koscuska 1, 11000 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaUsnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano- and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro- and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.https://www.mdpi.com/1999-4923/12/2/156usnic acidnanocarriersmicrocarriersdelivery systemsnatural products |
| spellingShingle | Ana Zugic Vanja Tadic Snezana Savic Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature Pharmaceutics usnic acid nanocarriers microcarriers delivery systems natural products |
| title | Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature |
| title_full | Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature |
| title_fullStr | Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature |
| title_full_unstemmed | Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature |
| title_short | Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature |
| title_sort | nano and microcarriers as drug delivery systems for usnic acid review of literature |
| topic | usnic acid nanocarriers microcarriers delivery systems natural products |
| url | https://www.mdpi.com/1999-4923/12/2/156 |
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