SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood an...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20642-x |
| _version_ | 1818682721332887552 |
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| author | Yashavanth Shaan Lakshmanappa Sonny R. Elizaldi Jamin W. Roh Brian A. Schmidt Timothy D. Carroll Kourtney D. Weaver Justin C. Smith Anil Verma Jesse D. Deere Joseph Dutra Mars Stone Sergej Franz Rebecca Lee Sammak Katherine J. Olstad J. Rachel Reader Zhong-Min Ma Nancy K. Nguyen Jennifer Watanabe Jodie Usachenko Ramya Immareddy JoAnn L. Yee Daniela Weiskopf Alessandro Sette Dennis Hartigan-O’Connor Stephen J. McSorley John H. Morrison Nam K. Tran Graham Simmons Michael P. Busch Pamela A. Kozlowski Koen K. A. Van Rompay Christopher J. Miller Smita S. Iyer |
| author_facet | Yashavanth Shaan Lakshmanappa Sonny R. Elizaldi Jamin W. Roh Brian A. Schmidt Timothy D. Carroll Kourtney D. Weaver Justin C. Smith Anil Verma Jesse D. Deere Joseph Dutra Mars Stone Sergej Franz Rebecca Lee Sammak Katherine J. Olstad J. Rachel Reader Zhong-Min Ma Nancy K. Nguyen Jennifer Watanabe Jodie Usachenko Ramya Immareddy JoAnn L. Yee Daniela Weiskopf Alessandro Sette Dennis Hartigan-O’Connor Stephen J. McSorley John H. Morrison Nam K. Tran Graham Simmons Michael P. Busch Pamela A. Kozlowski Koen K. A. Van Rompay Christopher J. Miller Smita S. Iyer |
| author_sort | Yashavanth Shaan Lakshmanappa |
| collection | DOAJ |
| description | Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and generation of germinal center Tfh cells specific for viral proteins. |
| first_indexed | 2024-12-17T10:23:21Z |
| format | Article |
| id | doaj.art-0b3b94e948d5442aa6b0f00f729b8c20 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:23:21Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0b3b94e948d5442aa6b0f00f729b8c202022-12-21T21:52:44ZengNature PortfolioNature Communications2041-17232021-01-0112111410.1038/s41467-020-20642-xSARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaquesYashavanth Shaan Lakshmanappa0Sonny R. Elizaldi1Jamin W. Roh2Brian A. Schmidt3Timothy D. Carroll4Kourtney D. Weaver5Justin C. Smith6Anil Verma7Jesse D. Deere8Joseph Dutra9Mars Stone10Sergej Franz11Rebecca Lee Sammak12Katherine J. Olstad13J. Rachel Reader14Zhong-Min Ma15Nancy K. Nguyen16Jennifer Watanabe17Jodie Usachenko18Ramya Immareddy19JoAnn L. Yee20Daniela Weiskopf21Alessandro Sette22Dennis Hartigan-O’Connor23Stephen J. McSorley24John H. Morrison25Nam K. Tran26Graham Simmons27Michael P. Busch28Pamela A. Kozlowski29Koen K. A. Van Rompay30Christopher J. Miller31Smita S. Iyer32Center for Immunology and Infectious Diseases, UC DavisCenter for Immunology and Infectious Diseases, UC DavisCenter for Immunology and Infectious Diseases, UC DavisCenter for Immunology and Infectious Diseases, UC DavisCalifornia National Primate Research Center, UC DavisDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences CenterDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences CenterCenter for Immunology and Infectious Diseases, UC DavisCalifornia National Primate Research Center, UC DavisCalifornia National Primate Research Center, UC DavisDepartment of Laboratory Medicine, University of CaliforniaVitalant Research InstituteCalifornia National Primate Research Center, UC DavisCalifornia National Primate Research Center, UC DavisCalifornia National Primate Research Center, UC DavisCalifornia National Primate Research Center, UC DavisCenter for Immunology and Infectious Diseases, UC DavisCalifornia National Primate Research Center, UC DavisCalifornia National Primate Research Center, UC DavisCalifornia National Primate Research Center, UC DavisCalifornia National Primate Research Center, UC DavisCenter for Infectious Disease and Vaccine Research, La Jolla Institute for ImmunologyCenter for Infectious Disease and Vaccine Research, La Jolla Institute for ImmunologyCalifornia National Primate Research Center, UC DavisCenter for Immunology and Infectious Diseases, UC DavisCalifornia National Primate Research Center, UC DavisPathology and Laboratory Medicine, School of Medicine, UC DavisDepartment of Laboratory Medicine, University of CaliforniaDepartment of Laboratory Medicine, University of CaliforniaDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences CenterCalifornia National Primate Research Center, UC DavisCenter for Immunology and Infectious Diseases, UC DavisCenter for Immunology and Infectious Diseases, UC DavisInduction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and generation of germinal center Tfh cells specific for viral proteins.https://doi.org/10.1038/s41467-020-20642-x |
| spellingShingle | Yashavanth Shaan Lakshmanappa Sonny R. Elizaldi Jamin W. Roh Brian A. Schmidt Timothy D. Carroll Kourtney D. Weaver Justin C. Smith Anil Verma Jesse D. Deere Joseph Dutra Mars Stone Sergej Franz Rebecca Lee Sammak Katherine J. Olstad J. Rachel Reader Zhong-Min Ma Nancy K. Nguyen Jennifer Watanabe Jodie Usachenko Ramya Immareddy JoAnn L. Yee Daniela Weiskopf Alessandro Sette Dennis Hartigan-O’Connor Stephen J. McSorley John H. Morrison Nam K. Tran Graham Simmons Michael P. Busch Pamela A. Kozlowski Koen K. A. Van Rompay Christopher J. Miller Smita S. Iyer SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques Nature Communications |
| title | SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques |
| title_full | SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques |
| title_fullStr | SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques |
| title_full_unstemmed | SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques |
| title_short | SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques |
| title_sort | sars cov 2 induces robust germinal center cd4 t follicular helper cell responses in rhesus macaques |
| url | https://doi.org/10.1038/s41467-020-20642-x |
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