Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis
Several studies performed in humans have demonstrated that the onset of systemic inflammatory response syndrome (SIRS) represents a high risk condition to develop myocardial damage and arrhythmias. Therefore, we also hypothesized cardiac involment for dogs affected by SIRS. To assess this hypothesis...
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MDPI AG
2022-11-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/12/655 |
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| author | Michela Pugliese Rocky La Maestra Monica Ragusa Mehmet Erman Or Giordana Merola Ettore Napoli Annamaria Passantino |
| author_facet | Michela Pugliese Rocky La Maestra Monica Ragusa Mehmet Erman Or Giordana Merola Ettore Napoli Annamaria Passantino |
| author_sort | Michela Pugliese |
| collection | DOAJ |
| description | Several studies performed in humans have demonstrated that the onset of systemic inflammatory response syndrome (SIRS) represents a high risk condition to develop myocardial damage and arrhythmias. Therefore, we also hypothesized cardiac involment for dogs affected by SIRS. To assess this hypothesis, 24 dogs with a diagnosis of SIRS (13 entire males, 7 entire females, and 4 spayed females) with an age ranging from 4 to 11 years (mean 5.6 years) and an average weight of 24 kg (range from 5 to 47 kg) were enrolled. The dogs were divided into two groups according to their prognosis: Survivors (G1) and not survivors (G2), composed by 13 and 11 dogs, respectively. Moreover, healthy dogs were included as the control group (CTR). All the dogs with a history of cardiac or renal disease were excluded. At the inclusion, each patient underwent a physical examination and a complete cell count, and a biochemistry panel (including electrolyte profile) was performed; moreover, the blood cardiac Troponin I (cTnI) was measured. For each clinical variable indicative of SIRS, a score between 0 (absence) and 1 (presence) was applied. Furthermore, an electrocardiographic examination was recorded. Seventeen out of 24 (70.8%) dogs with SIRS showed arrhythmias, of which n. 6 belonged to the G1, while n. 11 belonged to the G2. Most represented findings were sinus tachycardia (7/17; 41.1%), followed by monomorphic premature ventricular beats (6/17; 35.3%), less common were first-degree atrioventricular block (2/17; 11.7%) and sinus bradycardia 1/17; 5.8%). Notably, in G1 dogs, only sinus tachycardia and premature ventricular beats were observed. G2 dogs presented a number of total and banded leukocytes significantly higher than those of G1 (<i>p</i> = 0.002 and 0.049), in the same manner, the clinical score suggestive of SIRS (3 vs. 2.1) was significantly higher in G2 than in G1 dogs (<i>p</i> = 0.01). Moreover, a significantly higher value of cTnI was observed in the G2 group compared to the G1 group (<i>p</i> = 0.006). Data presented here suggested a cardiac involvement in dogs with SIRS, analogously to humans, that may significantly influence the patient’s prognosis. |
| first_indexed | 2024-03-09T15:45:22Z |
| format | Article |
| id | doaj.art-0b3cf127c0ee4cd8a4511e28514fdcca |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-09T15:45:22Z |
| publishDate | 2022-11-01 |
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| spelling | doaj.art-0b3cf127c0ee4cd8a4511e28514fdcca2023-11-24T18:34:50ZengMDPI AGVeterinary Sciences2306-73812022-11-0191265510.3390/vetsci9120655Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS DiagnosisMichela Pugliese0Rocky La Maestra1Monica Ragusa2Mehmet Erman Or3Giordana Merola4Ettore Napoli5Annamaria Passantino6Department of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, ItalyComplex Structure of Surgical Sciences and Technologies, IRCCS—Scientific Institute for Research, Hospitalization and Healthcare—Istituto Ortopedico Rizzoli, Via Di Barbiano 1/10, 40136 Bologna, ItalyFaculty of Veterinary Medicine, İstanbul University-Cerrahpasa, Istanbul 34098, TurkeyDepartment of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, ItalySeveral studies performed in humans have demonstrated that the onset of systemic inflammatory response syndrome (SIRS) represents a high risk condition to develop myocardial damage and arrhythmias. Therefore, we also hypothesized cardiac involment for dogs affected by SIRS. To assess this hypothesis, 24 dogs with a diagnosis of SIRS (13 entire males, 7 entire females, and 4 spayed females) with an age ranging from 4 to 11 years (mean 5.6 years) and an average weight of 24 kg (range from 5 to 47 kg) were enrolled. The dogs were divided into two groups according to their prognosis: Survivors (G1) and not survivors (G2), composed by 13 and 11 dogs, respectively. Moreover, healthy dogs were included as the control group (CTR). All the dogs with a history of cardiac or renal disease were excluded. At the inclusion, each patient underwent a physical examination and a complete cell count, and a biochemistry panel (including electrolyte profile) was performed; moreover, the blood cardiac Troponin I (cTnI) was measured. For each clinical variable indicative of SIRS, a score between 0 (absence) and 1 (presence) was applied. Furthermore, an electrocardiographic examination was recorded. Seventeen out of 24 (70.8%) dogs with SIRS showed arrhythmias, of which n. 6 belonged to the G1, while n. 11 belonged to the G2. Most represented findings were sinus tachycardia (7/17; 41.1%), followed by monomorphic premature ventricular beats (6/17; 35.3%), less common were first-degree atrioventricular block (2/17; 11.7%) and sinus bradycardia 1/17; 5.8%). Notably, in G1 dogs, only sinus tachycardia and premature ventricular beats were observed. G2 dogs presented a number of total and banded leukocytes significantly higher than those of G1 (<i>p</i> = 0.002 and 0.049), in the same manner, the clinical score suggestive of SIRS (3 vs. 2.1) was significantly higher in G2 than in G1 dogs (<i>p</i> = 0.01). Moreover, a significantly higher value of cTnI was observed in the G2 group compared to the G1 group (<i>p</i> = 0.006). Data presented here suggested a cardiac involvement in dogs with SIRS, analogously to humans, that may significantly influence the patient’s prognosis.https://www.mdpi.com/2306-7381/9/12/655systemic inflammatory response syndrome (SIRS)cardiac dysfunctionmyocardial damagedog |
| spellingShingle | Michela Pugliese Rocky La Maestra Monica Ragusa Mehmet Erman Or Giordana Merola Ettore Napoli Annamaria Passantino Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis Veterinary Sciences systemic inflammatory response syndrome (SIRS) cardiac dysfunction myocardial damage dog |
| title | Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis |
| title_full | Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis |
| title_fullStr | Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis |
| title_full_unstemmed | Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis |
| title_short | Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis |
| title_sort | electrocardiographic findings and cardiac troponin i assay in dogs with sirs diagnosis |
| topic | systemic inflammatory response syndrome (SIRS) cardiac dysfunction myocardial damage dog |
| url | https://www.mdpi.com/2306-7381/9/12/655 |
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